E6AP inhibits G-CSFR turnover and functions by promoting its ubiquitin-dependent proteasome degradation.

[1]  N. Chattopadhyay,et al.  Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2. , 2016, Biochimica et biophysica acta.

[2]  N. Chattopadhyay,et al.  E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation* , 2015, The Journal of Biological Chemistry.

[3]  N. Chattopadhyay,et al.  Proteomic discovery of MNT as a novel interacting partner of E3 ubiquitin ligase E6AP and a key mediator of myeloid differentiation , 2015, Oncotarget.

[4]  G. Behre,et al.  E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation. , 2013, Biochimica et biophysica acta.

[5]  G. Behre,et al.  Proteomic identification of Profilin1 as a corepressor of estrogen receptor alpha in MCF7 breast cancer cells , 2013, Proteomics.

[6]  G. Behre,et al.  E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBPα for ubiquitin-mediated proteasome degradation , 2013, Cell Death and Disease.

[7]  P. Pandolfi,et al.  E6ap Ubiquitin Ligase Regulates Pml-induced Senescence in Myc-driven Lymphomagenesis Neoplastic Transformation Requires the Elimination of Key Tumor Suppressors, Which May Result from E3 Ligase-mediated Proteasomal Degradation. We Previously Demonstrated a Key Role for the E3 Ubiqui- Tin Ligase E6ap , 2022 .

[8]  K. Stoeber,et al.  Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-β-TrCP, sequentially regulate glycolysis during the cell cycle , 2011, Proceedings of the National Academy of Sciences.

[9]  Qiaojun He,et al.  The ubiquitin-proteasome pathway plays essential roles in ATRA-induced leukemia cells G0/G1 phase arrest and transition into granulocytic differentiation , 2010, Cancer biology & therapy.

[10]  Melissa G. Piper,et al.  Neutrophil elastase downmodulates native G-CSFR expression and granulocyte-macrophage colony formation , 2010, Journal of Inflammation.

[11]  A. Mishra,et al.  UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27 , 2009, Neurobiology of Disease.

[12]  Y. Sugiyama,et al.  Identification of annexin A1 as a novel substrate for E6AP‐mediated ubiquitylation , 2009, Journal of cellular biochemistry.

[13]  L. Druhan,et al.  G-CSFR Ubiquitination Critically Regulates Myeloid Cell Survival and Proliferation , 2008, PloS one.

[14]  J. Shively,et al.  Differential cell fates induced by all‐trans retinoic acid‐treated HL‐60 human leukemia cells , 2008, Journal of leukocyte biology.

[15]  J. Tavernier,et al.  Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling , 2007, Oncogene.

[16]  G. Behre,et al.  Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPα by inhibiting its ubiquitination , 2007, Oncogene.

[17]  J. Pierre,et al.  JAK/STAT signal transduction: regulators and implication in hematological malignancies. , 2006, Biochemical pharmacology.

[18]  V. Moucadel,et al.  Differential STAT5 Signaling by Ligand-dependent and Constitutively Active Cytokine Receptors* , 2005, Journal of Biological Chemistry.

[19]  B. Clurman,et al.  A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates c-Myc and Cell Size , 2004, Current Biology.

[20]  Ying Qi,et al.  Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization* , 2003, Journal of Biological Chemistry.

[21]  C. Smith,et al.  The murine myeloid cell line 32Dcl3 as a model system for studying neutrophil functions. , 2003, Journal of immunological methods.

[22]  W. Alexander,et al.  The SOCS box: a tale of destruction and degradation. , 2002, Trends in biochemical sciences.

[23]  I. Touw,et al.  Multiple Signals Mediate Proliferation, Differentiation, and Survival from the Granulocyte Colony-stimulating Factor Receptor in Myeloid 32D Cells* , 1999, The Journal of Biological Chemistry.

[24]  M. Tsai,et al.  The Angelman Syndrome-Associated Protein, E6-AP, Is a Coactivator for the Nuclear Hormone Receptor Superfamily , 1999, Molecular and Cellular Biology.

[25]  B. Avalos,et al.  Deletion of a critical internalization domain in the G-CSFR in acute myelogenous leukemia preceded by severe congenital neutropenia. , 1999, Blood.

[26]  Aaron Ciechanover,et al.  The ubiquitin–proteasome pathway: on protein death and cell life , 1998, The EMBO journal.

[27]  P. Howley,et al.  The Role of E6AP in the Regulation of p53 Protein Levels in Human Papillomavirus (HPV)-positive and HPV-negative Cells* , 1998, The Journal of Biological Chemistry.

[28]  B. Avalos,et al.  Molecular analysis of the granulocyte colony-stimulating factor receptor. , 1996, Blood.

[29]  K. Foetisch,et al.  An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner. , 1995, Biochemical and biophysical research communications.

[30]  A R Dunn,et al.  Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. , 1994, Blood.

[31]  D. Tweardy,et al.  Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. , 1987, Journal of immunology.

[32]  D. Tweardy,et al.  Stat3 and G-CSF-induced myeloid differentiation. , 1998, Leukemia & lymphoma.