Derivation and Prospective Testing of a Two-step Sevoflurane-O2-N2O Low Fresh Gas Flow Sequence

Simple vaporiser setting (FD) and fresh gas flow (FGF) sequences make the practice of low-flow anaesthesia not only possible but also easy to achieve. We sought to derive a sevoflurane FD sequence that maintains the end-expired sevoflurane concentration (FAsevo) at 1.3% using the fewest possible number of FD adjustments with a previously described O2-N2O FGF sequence that allows early FGF reduction to 0.7 l.min−1. In 18 ASA physical status I to II patients, FD was determined to maintain FAsevo at 1.3% with 2 l.min−1 O2 and 4 l.min−1 N2O FGF for three minutes, and with 0.3 and 0.4 l.min−1 thereafter. Using the same FGF sequence, the FD schedule that approached the 1.3% FAsevo pattern with the fewest possible adjustments was prospectively tested in another 18 patients. The following FD sequence approximated the FD course well: 2% from zero to three minutes, 2.6% from three to 15 minutes and 2.0% after 15 minutes. When prospectively tested, median (25th; 75th percentile) performance error was 0.8 (-2.9; 5.9)%, absolute performance error 6.7 (3.3; 10.6)%, divergence 18.2 (-5.6; 27.4)%.h−1 and wobble 4.4 (1.7; 8.1)%. In one patient, FGF had to be temporarily increased for four minutes. One O2/N2O rotameter FGF setting change from 6 to 0.7 l.min−1 at three minutes and two sevoflurane FD changes at three and 15 minutes maintained predictable anaesthetic gas concentrations during the first 45 minutes in all but one patient in our study.