Spinal metastases: treatment evaluation algorithm.

Spinal metastases are only apparently similar lesions, considering the large varieties of istotypes and the spread of the primary tumor. These metastases develop early and are not terminal events, they have to be considered as severe complications because, when possible, surgical treatment can improve the history of the patient in terms of life expectancy and quality of life. The approach to these lesions should be multidisciplinary in collaboration with oncologists and radiotherapists, in fact the average of survival of these patients has increased in recent years. The evolution of anesthaesiological techniques that permit surgical treatments that were once considered prohibitive. The application of new adjuvant therapy increases the effectiveness for surgical treatment. Controversy exist over the most appropriate treatment for patients with metastatic disease of the vertebral column. The purpose of this article was to determine the best sequential process to arrive at the most appropriate treatment considering the individual general conditions and the parameters of the metastases. We review 269 cases in 182 patients suffering from spinal metastases from a solid tumour treated between 1996 and 2002. As the number of treatment options for metastatic spinal disease has grown, it has become clear that effective implementation of these treatments can only be achieved by multidisciplinary approach.

[1]  P. Gerszten,et al.  Evidence-based review of the surgical management of vertebral column metastatic disease. , 2003, Neurosurgical focus.

[2]  K. Kelliher,et al.  Surgery for Solitary Metastases of the Spine: Rationale and Results of Treatment , 2002, Spine.

[3]  C. Matula,et al.  Neurological outcome following laminectomy in spinal metastases , 2002, Spinal Cord.

[4]  K. Tomita,et al.  Surgical strategy for spinal metastases. , 2002, Spine.

[5]  M. Grady,et al.  Medical management and adjuvant therapies in spinal metastatic disease. , 2001, Neurosurgical focus.

[6]  W B Jacobs,et al.  Evaluation and treatment of spinal metastases: an overview. , 2001, Neurosurgical focus.

[7]  K. Yamamoto,et al.  [Perioperative management for total en bloc spondylectomy--the effects of preoperative embolization and hypotensive anesthesia]. , 2000, Masui. The Japanese journal of anesthesiology.

[8]  F. Sim,et al.  Surgical treatment for metastatic disease of the pelvis and the proximal end of the femur. , 2000, Instructional course lectures.

[9]  M Maghsudi,et al.  Surgical management of symptomatic spinal metastases. Postoperative outcome and quality of life. , 1999, Spine.

[10]  J J Wise,et al.  Complication, survival rates, and risk factors of surgery for metastatic disease of the spine. , 1999, Spine.

[11]  K. Harrington Orthopedic surgical management of skeletal complications of malignancy , 1997, Cancer.

[12]  G. Krol,et al.  Indications and results of combined anterior-posterior approaches for spine tumor surgery , 1996 .

[13]  P. Sioutos,et al.  Spinal metastases from solid tumors. Analysis of factors affecting survival , 1995, Cancer.

[14]  K. Yonenobu,et al.  Orthopaedic management of spinal metastases. , 1995, Clinical orthopaedics and related research.

[15]  B. Belkhouche,et al.  Acknowledgements We Would like to Thank , 1993 .

[16]  N Sundaresan,et al.  Treatment of neoplastic spinal cord compression: results of a prospective study. , 1991, Neurosurgery.

[17]  Y. Tokuhashi,et al.  Scoring System for the Preoperative Evaluation of Metastatic Spine Tumor Prognosis , 1990, Spine.

[18]  R. Young,et al.  Treatment of spinal epidural metastases. Randomized prospective comparison of laminectomy and radiotherapy. , 1980, Journal of neurosurgery.

[19]  H. Frankel Ascending cord lesion in the early stages following spinal injury , 1969, Paraplegia.