A Computational Model of Motor Neuron Degeneration

[1]  P. Pasinelli,et al.  Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis. , 2014, Biochimica et biophysica acta.

[2]  Mackenzie W. Mathis,et al.  Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS , 2014, Neuron.

[3]  Y. Kaneda,et al.  Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma. , 2014, Cancer research.

[4]  T. A. Ryan,et al.  Activity-Driven Local ATP Synthesis Is Required for Synaptic Function , 2014, Cell.

[5]  Peter Jonas,et al.  Loose Coupling Between Ca2+ Channels and Release Sensors at a Plastic Hippocampal Synapse , 2014, Science.

[6]  A. Chiò,et al.  The metabolic signature of C9ORF72-related ALS: FDG PET comparison with nonmutated patients , 2014, European Journal of Nuclear Medicine and Molecular Imaging.

[7]  N. Renier,et al.  Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin , 2013, Neuron.

[8]  P. Caroni,et al.  Neuroprotection through Excitability and mTOR Required in ALS Motoneurons to Delay Disease and Extend Survival , 2013, Neuron.

[9]  George S. B. Williams,et al.  Mitochondrial calcium uptake , 2013, Proceedings of the National Academy of Sciences.

[10]  George S. B. Williams,et al.  NCLX: the mitochondrial sodium calcium exchanger. , 2013, Journal of molecular and cellular cardiology.

[11]  Robert H. Brown,et al.  Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability. , 2013, Journal of neurophysiology.

[12]  Nick C Fox,et al.  Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels , 2013, Neuron.

[13]  J. Paul Bolam,et al.  The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease , 2013, Front. Comput. Neurosci..

[14]  Kristen M. Naegle,et al.  Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration , 2013, Cell.

[15]  D. Attwell,et al.  Synaptic Energy Use and Supply , 2012, Neuron.

[16]  R. Rizzuto,et al.  The mitochondrial Ca(2+) uniporter. , 2012, Cell calcium.

[17]  David Attwell,et al.  Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing , 2012, The Journal of Neuroscience.

[18]  Janel O. Johnson,et al.  Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study , 2012, The Lancet Neurology.

[19]  Christine Grienberger,et al.  Imaging Calcium in Neurons , 2012, Neuron.

[20]  Sherif M. Elbasiouny,et al.  Contribution of intrinsic properties and synaptic inputs to motoneuron discharge patterns: a simulation study. , 2012, Journal of neurophysiology.

[21]  Nagarajan Venkateswaran,et al.  Energetics Based Spike Generation of a Single Neuron: Simulation Results and Analysis , 2012, Front. Neuroenerg..

[22]  D. Friel,et al.  Combined computational and experimental approaches to understanding the Ca(2+) regulatory network in neurons. , 2012, Advances in experimental medicine and biology.

[23]  S. Ajroud‐Driss,et al.  SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis. , 2011, Archives of neurology.

[24]  E. Schon,et al.  Mitochondria: The Next (Neurode)Generation , 2011, Neuron.

[25]  A. Nose,et al.  Differential Control of Presynaptic CaMKII Activation and Translocation to Active Zones , 2011, The Journal of Neuroscience.

[26]  P. Nissen,et al.  P-type ATPases. , 2011, Annual review of biophysics.

[27]  Patrizia Sola,et al.  Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS , 2011, Neuron.

[28]  Erik Sahai,et al.  Deficits in axonal transport precede ALS symptoms in vivo , 2010, Proceedings of the National Academy of Sciences.

[29]  Simon B. Laughlin,et al.  Action Potential Energy Efficiency Varies Among Neuron Types in Vertebrates and Invertebrates , 2010, PLoS Comput. Biol..

[30]  C. Henderson,et al.  Motor neuron diversity in development and disease. , 2010, Annual review of neuroscience.

[31]  T. Sejnowski,et al.  Metabolic cost as a unifying principle governing neuronal biophysics , 2010, Proceedings of the National Academy of Sciences.

[32]  Takeo Kato,et al.  Mutations of optineurin in amyotrophic lateral sclerosis , 2010, Nature.

[33]  K. Mills,et al.  Detecting fasciculations in amyotrophic lateral sclerosis: duration of observation required , 2010, Journal of Neurology, Neurosurgery & Psychiatry.

[34]  L. Rowland Ameliorating amyotrophic lateral sclerosis. , 2010, The New England journal of medicine.

[35]  G. Perkins,et al.  Mitochondrial fragmentation in neurodegeneration , 2008, Nature Reviews Neuroscience.

[36]  S. Laughlin,et al.  Energy limitation as a selective pressure on the evolution of sensory systems , 2008, Journal of Experimental Biology.

[37]  Xun Hu,et al.  TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis , 2008, Science.

[38]  Dick F. Stegeman,et al.  Firing pattern of fasciculations in ALS , 2008, Neurology.

[39]  M. Iwata,et al.  Mitochondrial Alterations in the Spinal Cord of Patients With Sporadic Amyotrophic Lateral Sclerosis , 2007, Journal of neuropathology and experimental neurology.

[40]  P. Gardiner,et al.  Frequency–current relationships of rat hindlimb α‐motoneurones , 2006 .

[41]  P. Gardiner,et al.  Frequency-current relationships of rat hindlimb alpha-motoneurones. , 2006, The Journal of physiology.

[42]  Giorgio A Ascoli,et al.  Developmental changes in spinal motoneuron dendrites in neonatal mice , 2005, The Journal of comparative neurology.

[43]  M. Swash,et al.  Cramps, muscle pain, and fasciculations , 2004, Neurology.

[44]  Terrence J. Sejnowski,et al.  Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism , 1994, Journal of Computational Neuroscience.

[45]  S. Dimauro,et al.  Mitochondrial respiratory-chain diseases. , 2003, The New England journal of medicine.

[46]  Kelvin E Jones,et al.  A modelling study of locomotion‐induced hyperpolarization of voltage threshold in cat lumbar motoneurones , 2002, The Journal of physiology.

[47]  Paul Bach-y-Rita,et al.  The cost of an action potential , 2000, Journal of Neuroscience Methods.

[48]  Margaret A. Johnson,et al.  Mitochondrial enzyme activity in amyotrophic lateral sclerosis: Implications for the role of mitochondria in neuronal cell death , 1999, Annals of neurology.

[49]  D. Kernell,et al.  Discharge properties of motoneurones: How are they matched to the properties and use of their muscle units? , 1999, Journal of Physiology-Paris.

[50]  P. Pohl,et al.  The size of the unstirred layer as a function of the solute diffusion coefficient. , 1998, Biophysical journal.

[51]  M. Berridge Neuronal Calcium Signaling , 1998, Neuron.

[52]  J C Pearson,et al.  Distribution of 5‐hydroxytryptamine‐immunoreactive boutons on α‐motoneurons in the lumbar spinal cord of adult cats , 1998, The Journal of comparative neurology.

[53]  M. Swash,et al.  Fasciculation potentials: A study of amyotrophic lateral sclerosis and other neurogenic disorders , 1998, Muscle & nerve.

[54]  M. Swash,et al.  Fasciculations: what do we know of their significance? , 1997, Journal of the Neurological Sciences.

[55]  Nicholas T. Carnevale,et al.  The NEURON Simulation Environment , 1997, Neural Computation.

[56]  B. Locke,et al.  The effects of temperature, pH, and magnesium on the diffusion coefficient of ATP in solutions of physiological ionic strength. , 1996, Biochimica et biophysica acta.

[57]  D. Clapham,et al.  Calcium signaling , 1995, Cell.

[58]  R. Layzer The origin of muscle fasciculations and cramps , 1994, Muscle & nerve.

[59]  M D Binder,et al.  Computer simulations of motoneuron firing rate modulation. , 1993, Journal of neurophysiology.

[60]  E. Marder,et al.  Activity-dependent regulation of conductances in model neurons. , 1993, Science.

[61]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1990, Bulletin of mathematical biology.

[62]  W. N. Ross,et al.  Changes in intracellular calcium during neuron activity. , 1989, Annual review of physiology.

[63]  R. Burke,et al.  Membrane area and dendritic structure in type‐identified triceps surae alpha motoneurons , 1987, The Journal of comparative neurology.

[64]  R. Broadwell,et al.  The neuronal endoplasmic reticulum: Its cytochemistry and contribution to the endomembrane system. II. Axons and terminals , 1984, The Journal of comparative neurology.

[65]  L. Kurland,et al.  Fine Structural Study of Neurofibrillary Changes in a Family with Amyotrophic Lateral Sclerosis , 1984, Journal of neuropathology and experimental neurology.

[66]  R. Broadwell,et al.  The neuronal endoplasmic reticulum: its cytochemistry and contribution to the endomembrane system. I. Cell bodies and dendrites. , 1983, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[67]  G Roth,et al.  The origin of fasciculations , 1982, Annals of neurology.

[68]  R. Burke Motor unit types: functional specializations in motor control , 1980, Trends in Neurosciences.

[69]  W. Crill,et al.  Voltage‐sensitive outward currents in cat motoneurones. , 1980, The Journal of physiology.

[70]  W. Brown Functional compensation of human motor units in health and disease. , 1973, Journal of the neurological sciences.

[71]  C. Terzuolo,et al.  Membrane currents in spinal motoneurons associated with the action potential and synaptic activity. , 1962, Journal of neurophysiology.

[72]  D. Denny-Brown,et al.  FIBRILLATION AND FASCICULATION IN VOLUNTARY MUSCLE , 1938 .