The potential of Macaranga plants as skincare cosmetic ingredients: A review

The application of bioactive ingredients extracted from plants utilized as additives in various cosmetic products has gained popularity, since they are safe, with low adverse effects when applied properly, and are environmentally friendly. Moreover, the awareness of healthier cosmetic products has rapidly increased so that the exploration of screened plants with appropriate properties has attracted significant attention worldwide. This review discusses the potential of one of the fastest-growing tropical plants, Macaranga , applied in skincare cosmetics. Their interesting characteristics, such as being anti-inflammatory, antioxidant, and antimicrobial, and their tyrosinase inhibitory effect have been comprehensively summarized. Various scientific literature works have further proven ethnopharmacological studies that explore the traditional use of Macaranga species by local people in the tropics for medicinal and skincare purposes. Therefore, we believe this will allow Macaranga to become a promising material in the future for large-scale industrial skincare cosmetics.

[1]  Yue‐wen Chen,et al.  Antibacterial and Antioxidant Activity of the Fruit of Macaranga tanarius, the Plant Origin of Taiwanese Green Propolis , 2022, Antioxidants.

[2]  M. Grisel,et al.  Multifunctional active ingredient-based delivery systems for skincare formulations: A review. , 2022, Colloids and surfaces. B, Biointerfaces.

[3]  H. Wahab,et al.  In Vitro and In Silico Anti-Acetylcholinesterase Activity from Macaranga tanarius and Syzygium jambos , 2022, Molecules.

[4]  J. Onyari,et al.  Conglomeratin: a new antibacterial flavonol derivative from Macaranga conglomerata Brenan (Euphorbiaceae) , 2022, Natural product research.

[5]  M. Frese,et al.  Antibacterial flavonoids from the fruits of Macaranga hurifolia , 2022, Journal of Asian natural products research.

[6]  E. Guzmán,et al.  Essential Oils and Their Individual Components in Cosmetic Products , 2021, Cosmetics.

[7]  Young‐Chul Lee,et al.  Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives , 2021, Cosmetics.

[8]  N. Saputra,et al.  Identification on chemical organic compounds of Macaranga hypoleuca by using Py-GCMS , 2021, IOP Conference Series: Earth and Environmental Science.

[9]  I. Castellano,et al.  From Sea to Skin: Is There a Future for Natural Photoprotectants? , 2021, Marine drugs.

[10]  S. Haque,et al.  Oxidative-Stress-Induced Cellular Toxicity and Glycoxidation of Biomolecules by Cosmetic Products under Sunlight Exposure , 2021, Antioxidants.

[11]  J. Woo,et al.  Prenylflavonoids from fruit of Macaranga tanarius promote glucose uptake via AMPK activation in L6 myotubes , 2021, Journal of Natural Medicines.

[12]  L. Fiandra,et al.  The emerging role of nanotechnology in skincare. , 2021, Advances in colloid and interface science.

[13]  H. Shin,et al.  Prenylflavonoids isolated from Macaranga tanarius stimulate odontoblast differentiation of human dental pulp stem cells and tooth-root formation via the mitogen-activated protein kinase and protein kinase B pathways. , 2021, International Endodontic Journal.

[14]  Tiago G. Morais,et al.  Seaweeds Compounds: An Ecosustainable Source of Cosmetic Ingredients? , 2021 .

[15]  Hailun He,et al.  Natural components in sunscreens: Topical formulations with sun protection factor (SPF). , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[16]  E. Jabłońska,et al.  Controversy around parabens: alternative strategies for preservative use in cosmetics and personal care products. , 2020, Environmental research.

[17]  M. Litaudon,et al.  New flavonoid and stilbene derivatives from the fruits of Macaranga balansae , 2020, Natural product research.

[18]  S. Tawata,et al.  Chemical composition and pharmacological properties of Macaranga‐type Pacific propolis: A review , 2020, Phytotherapy research : PTR.

[19]  J. Hošek,et al.  Therapeutic potential of prenylated stilbenoid macasiamenene F through its anti-inflammatory and cytoprotective effects on LPS-challenged monocytes and microglia. , 2020, Journal of ethnopharmacology.

[20]  Weilie Xiao,et al.  The natural compound Cirsitakaoside enhances antiviral innate responses against vesicular stomatitis virus in vitro and in vivo. , 2020, International immunopharmacology.

[21]  N. T. Linh,et al.  Stilbenes from Macaranga tanarius (Euphorbiaceae) growing in Vietnam , 2020 .

[22]  R. P,et al.  Evaluation of Antioxidant and Antimicrobial Activity of Some Plants Collected from Malaysia , 2019 .

[23]  N. Cuc,et al.  Cytotoxic prenylated flavonoids from the leaves of Macaranga indica , 2019 .

[24]  M. Muhaimin,et al.  Antiplasmodial Activity of Ethanolic Extract of Macaranga Gigantea Leaf and Its Major Constituent , 2019, Pharmacognosy Journal.

[25]  A. Mollica,et al.  Chemical profiling, antioxidant, enzyme inhibitory and molecular modelling studies on the leaves and stem bark extracts of three African medicinal plants. , 2019, Journal of pharmaceutical and biomedical analysis.

[26]  N. Cuc,et al.  Prenylated flavonoids and other constituents from Macaranga indica , 2019, Natural product research.

[27]  M. Tanjung,et al.  Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage , 2019, Natural Product Sciences.

[28]  C. Fogarassy,et al.  Green Consumer Behavior in the Cosmetics Market , 2019, Resources.

[29]  E. Rosamah,et al.  Antioxidant and Antimelanogenesis Activities of Glyasperin A From Macaranga pruinosa Leaves , 2019, Natural Product Communications.

[30]  A. Adeniji,et al.  In vitro anti-enteroviral activity of stilbenoids isolated from the leaves of Macaranga barteri , 2019, Natural product research.

[31]  A. Mensah,et al.  Macaranga barteri stem bark extract exerts anti-inflammatory and anti-hyperalgesia activity in murine models , 2019, Discovery Phytomedicine.

[32]  J. Woo,et al.  Antimicrobial and antibiofilm activities of prenylated flavanones from Macaranga tanarius. , 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[33]  Tran Nguyen Le,et al.  Cytotoxic phenolic compounds isolated from the fruits of Macaranga denticulata , 2019, Natural product research.

[34]  Benedict R. Zapanta,et al.  Species richness of trees in disturbed habitats within a protected area and its implications for conservation: The case of Mt. Apo Natural Park, Mindanao Island, Philippines , 2019, Biodiversitas Journal of Biological Diversity.

[35]  N. Ahmat,et al.  New dihydrostilbenes from Macaranga heynei I.M. Johnson, biological activities and structure-activity relationship , 2019, Phytochemistry Letters.

[36]  Fyaz M. D. Ismail,et al.  Bioassay-guided isolation and structure elucidation of cytotoxic stilbenes and flavonols from the leaves of Macaranga barteri. , 2019, Fitoterapia.

[37]  A. Ogundajo,et al.  Chemical profiling, antioxidant and carbohydrate-metabolising enzymes inhibitory potential of fractions from the leaves of Macaranga bateri Mull-Arg , 2019 .

[38]  Pienyani Rosawanti,et al.  ANTIOXIDANT ACTIVITY OF ETHYL ACETATE FRACTION OF MACARANGA TRILOBA LEAVES FROM CENTRAL KALIMANTAN , 2018, Asian Journal of Pharmaceutical and Clinical Research.

[39]  W. Ahmad,et al.  Raging the War Against Inflammation With Natural Products , 2018, Front. Pharmacol..

[40]  D. Monti,et al.  Antioxidants from Plants Protect against Skin Photoaging , 2018, Oxidative medicine and cellular longevity.

[41]  O. Ogbole,et al.  Antimicrobial and antiprotozoal activities of twenty-four Nigerian medicinal plant extracts , 2018, South African Journal of Botany.

[42]  R. Amirta,et al.  Nutrient distribution on soil and aboveground biomass of Macaranga gigantea five years after planting , 2018, Asian Journal of Forestry.

[43]  H. Otsuka,et al.  Okinawan Subtropical Plants as a Promising Resource for Novel Chemical Treasury. , 2018, Chemical and pharmaceutical bulletin.

[44]  M. Tanjung,et al.  Antiplasmodial activity of flavonoids from Macaranga tanarius leaves , 2018 .

[45]  Y. Paul,et al.  Acute toxicity and gastric anti-ulcer activity of an aqueous extract of the leaves of Macaranga barteri Mll.Arg (Euphorbiaceae) on rat models , 2018 .

[46]  M. Tanjung,et al.  Chemical Composition and Anticancer Activity of Macaranga hosei Leaves , 2018 .

[47]  J. Santiago,et al.  Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils , 2017, International journal of molecular sciences.

[48]  N. D. A. Razak,et al.  Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae) , 2017 .

[49]  A. Hasanat,et al.  Antinociceptive Activity of Macaranga denticulata Muell. Arg. (Family: Euphorbiaceae): In Vivo and In Silico Studies , 2017, Medicines.

[50]  S. Kumazawa,et al.  Nymphaeol-C, a prenylflavonoid from Macaranga tanarius, suppresses the expression of fibroblast growth factor 18. , 2017, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[51]  W. Luyten,et al.  Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India , 2017, Front. Pharmacol..

[52]  M. Tanjung,et al.  Flavonoid and stilbene derivatives from Macaranga trichocarpa. , 2017, Fitoterapia.

[53]  J. Bignon,et al.  Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius. , 2017, Journal of natural products.

[54]  Jin Peihong,et al.  A new species of Macaranga from the middle Miocene of Fujian, China and its significance , 2017 .

[55]  R. M. Zulkifli,et al.  A review of Acalypha indica L. (Euphorbiaceae) as traditional medicinal plant and its therapeutic potential. , 2017, Journal of ethnopharmacology.

[56]  B. Okeleye,et al.  Chemical constituents, in vitro antimicrobial and cytotoxic potentials of the extracts from Macaranga barteri Mull-Arg , 2017 .

[57]  M. Tanjung,et al.  Prenylated Dihydrostilbenes from Macaranga rubiginosa , 2017, Chemistry of Natural Compounds.

[58]  J. Yue,et al.  Deheiculatins A-L, 20-oxygenated cembranoids from Macaranga deheiculata. , 2017, Phytochemistry.

[59]  Jia Li,et al.  Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata , 2016 .

[60]  J. Moreira,et al.  Antioxidant Effect of Nanoemulsions Containing Extract of Achyrocline satureioides (Lam) D.C.—Asteraceae , 2016, AAPS PharmSciTech.

[61]  A. Hou,et al.  Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulata , 2016, Natural Products and Bioprospecting.

[62]  E. Ghisalberti,et al.  Flavanone derivatives from Macaranga tanarius , 2015 .

[63]  C. Mahidol,et al.  Cytotoxic and cancer chemopreventive properties of prenylated stilbenoids from Macaranga siamensis , 2015 .

[64]  Wei‐Lie Xiao,et al.  Cytotoxic prenylated flavonoids from Macaranga indica. , 2015, Fitoterapia.

[65]  Wei‐Lie Xiao,et al.  Minor Prenylated Flavonoids from the Twigs of Macarangaadenantha and Their Cytotoxic Activity , 2015, Natural Products and Bioprospecting.

[66]  Wei‐Lie Xiao,et al.  Denticulatains A and B: unique stilbene-diterpene heterodimers from Macaranga denticulata† , 2015 .

[67]  Ke-Chun Liu,et al.  Cytotoxic prenylated bibenzyls and flavonoids from Macaranga kurzii. , 2014, Fitoterapia.

[68]  J. J. Magadula Phytochemistry and pharmacology of the genus Macaranga: A review , 2014 .

[69]  F. Abas,et al.  Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga Species , 2013, TheScientificWorldJournal.

[70]  L. Kardono,et al.  Scopoletin, a coumarin derivative compound isolated from Macaranga gigantifolia Merr , 2012 .

[71]  M. Litaudon,et al.  Acetylcholinesterase inhibitors from the leaves of Macaranga kurzii. , 2012, Journal of natural products.

[72]  J. Latip,et al.  Dihydroflavonol and Flavonol Derivatives from Macaranga Recurvata , 2012, Natural product communications.

[73]  N. Ahmat,et al.  Flavonoids with antiplasmodial and cytotoxic activities of Macaranga triloba. , 2012, Fitoterapia.

[74]  Y. M. Syah,et al.  Flavonoids from Macaranga lowii , 2012 .

[75]  E. Ghisalberti,et al.  Phenolic derivatives with an irregular sesquiterpenyl side chain from Macaranga pruinosa. , 2012, Natural Product Communications.

[76]  N. Russo,et al.  The molecular basis of working mechanism of natural polyphenolic antioxidants , 2011 .

[77]  Curtis J Henrich,et al.  Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2. , 2011, Journal of natural products.

[78]  J. Kawabata,et al.  Novel α-glucosidase inhibitors from Macaranga tanarius leaves , 2010 .

[79]  Yong-tang Zheng,et al.  Anti-human immunodeficiency virus-1 constituents of the bark of Poncirus trifoliata. , 2010, Chemical & pharmaceutical bulletin.

[80]  L. Maes,et al.  In vitro cytotoxic, antiprotozoal and antimicrobial activities of medicinal plants from Vanuatu , 2010, Phytotherapy research : PTR.

[81]  J. Beutler,et al.  Schweinfurthins I and J from Macaranga schweinfurthii. , 2010, Journal of natural products.

[82]  Chun-lin Long,et al.  Clerodane diterpenoids and prenylated flavonoids from Dodonaea viscosa , 2010, Journal of Asian natural products research.

[83]  N. Udupa,et al.  Screening of plant Macaranga peltata for its antioxidant, antimicrobial and cytotoxicity activity , 2009, 2009 International Conference on Biomedical and Pharmaceutical Engineering.

[84]  M. Hanafi,et al.  Macagigantin, a farnesylated flavonol from Macaranga gigantea , 2009, Journal of Asian natural products research.

[85]  S. Baboota,et al.  Nano Approaches to Enhance Pharmacokinetic and Pharmacodynamic Activity of Plant Origin Drugs , 2009 .

[86]  Y. Takeda,et al.  Absolute configuration of (+)-pinoresinol 4-O-[6''-O-galloyl]-beta-D-glucopyranoside, macarangiosides E, and F isolated from the leaves of Macaranga tanarius. , 2009, Phytochemistry.

[87]  Y. Lim,et al.  Evaluation of antioxidant, antibacterial and anti-tyrosinase activities of four Macaranga species , 2009 .

[88]  Liangxiong Xu,et al.  Prenylflavonols from the leaves of Macaranga sampsonii. , 2009, Chemical & pharmaceutical bulletin.

[89]  M. Choudhary,et al.  Inhibitory effect of macabarterin, a polyoxygenated ellagitannin from Macaranga barteri, on human neutrophil respiratory burst activity. , 2008, Journal of natural products.

[90]  Y. Takeda,et al.  Macaflavanones A-G, prenylated flavanones from the leaves of Macaranga tanarius. , 2008, Journal of natural products.

[91]  S. Kumazawa,et al.  Plant origin of Okinawan propolis: honeybee behavior observation and phytochemical analysis , 2008, Naturwissenschaften.

[92]  P. Elsner,et al.  Intrinsic and extrinsic factors in skin ageing: a review , 2008, International journal of cosmetic science.

[93]  Bing-jing Liu,et al.  [Study on the chemical constituents of liposoluble steroidal and triterpenoid compounds from the stem and bark of Macaranga hemsleyana]. , 2008, Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.

[94]  Arvind Saklani,et al.  Plant-derived compounds in clinical trials. , 2008, Drug discovery today.

[95]  Kyeong-Man Kim,et al.  Anti-allergic prenylated flavonoids from the roots of Sophora flavescens. , 2008, Planta medica.

[96]  J. Miller,et al.  Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest. , 2007, Journal of natural products.

[97]  G. Qin,et al.  A new geranyl flavanone from Macaranga triloba , 2006, Journal of Asian natural products research.

[98]  Somsak Ruchirawat,et al.  Constituents of the leaves of Macaranga tanarius. , 2005, Journal of natural products.

[99]  J. Rees,et al.  The genetics of sun sensitivity in humans. , 2004, American journal of human genetics.

[100]  J. Pezzuto,et al.  Potential cancer chemopreventive constituents of the leaves of Macaranga triloba. , 2004, Phytochemistry.

[101]  I. Khan,et al.  Antifungal clerodane diterpenes from Macaranga monandra (L) Muell. et Arg. (Euphorbiaceae). , 2003, Journal of agricultural and food chemistry.

[102]  A. Suksamrarn,et al.  Diterpenylated and prenylated flavonoids from Macaranga denticulata , 2002 .

[103]  Y. Kuo,et al.  Allelopathic prenylflavanones from the fallen leaves of Macaranga tanarius. , 2001, Journal of natural products.

[104]  M. Boyd,et al.  Cytotoxic geranyl stilbenes from Macaranga schweinfurthii. , 1998, Journal of natural products.

[105]  O. Sticher,et al.  Prenylated flavanones from leaves of Macaranga pleiostemona , 1995 .

[106]  Takashi Tanaka,et al.  Tannins and related compounds. XCVI, Structures of macaranins and macarinins, new hydrolyzable tannins possessing macaranoyl and tergalloyl ester groups, from the leaves of Macaranga sinensis (BAILL.) MUELL.-ARG. , 1990 .

[107]  K. Nakanishi,et al.  Isolation and structure of macarangonol, a diterpene ketol from Macaranga tanarius , 1971 .

[108]  A. Cahyana,et al.  SOLATION, CHARACTERIZATION AND ANTIDIABETIC ACTIVITY OF PHENOLIC COMPOUNDS ISOLATED FROM Macaranga magna TURRILL , 2021, RASAYAN Journal of Chemistry.

[109]  A. Fred-jaiyesimi,et al.  Investigation of the anti-inflammatory and hypoglycaemic effects of macaranga hurifolia beille (eurphorbiaceae) extract on wistar albino rats , 2019, ACTA Pharmaceutica Sciencia.

[110]  N. Rahman,et al.  PRENYLATED DIHYDROSTILBENES FROM Macaranga heynei (EUPHORBIACEAE) , 2018 .

[111]  Y. M. Syah,et al.  Prenylated 9,10‐Dihydrophenanthrenes from Macaranga javanica. , 2016 .

[112]  Yuliansyah,et al.  Comparative characterization of Macaranga species collected from secondary forests in East Kalimantan for biorefinery of unutilized fast growing wood. , 2016 .

[113]  Phebe Hendra,et al.  ANTIHYPERLIPIDEMIC AND HEPATOPROTECTIVE STUDIES ON LEAVES OF MACARANGA TANARIUS , 2016 .

[114]  N. Momose,et al.  Analysis of antioxidant prenylflavonoids in different parts of Macaranga tanarius, the plant origin of Okinawan propolis. , 2014, Asian Pacific journal of tropical medicine.

[115]  N. Ahmat,et al.  Flavanones from the Flower of Macaranga triloba , 2010 .

[116]  D. Berson Natural antioxidants. , 2008, Journal of drugs in dermatology : JDD.

[117]  T. Hemscheidt,et al.  Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa. , 2001, Journal of natural products.

[118]  F. Guéritte-Voegelein,et al.  A geranyl substituted flavonol from Macaranga vedeliana , 1990 .

[119]  S. Sultana,et al.  Chromenoflavones from Macaranga indica , 1986 .

[120]  A. Anjaneyulu,et al.  Isolation and characterisation of bergenin derivatives from Macaranga peltata , 1979 .