The Natural History of Symptomatic Androgen Deficiency in Men: Onset, Progression, and Spontaneous Remission

OBJECTIVES: To describe the onset, progression, and remission of symptomatic androgen deficiency (SAD) using longitudinal data from the Massachusetts Male Aging Study (MMAS).

[1]  V. Montori,et al.  Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. , 2010, The Journal of clinical endocrinology and metabolism.

[2]  J. Mckinlay,et al.  Intraindividual variation in levels of serum testosterone and other reproductive and adrenal hormones in men , 2007, Clinical endocrinology.

[3]  T. Travison,et al.  Prevalence of symptomatic androgen deficiency in men. , 2007, The Journal of clinical endocrinology and metabolism.

[4]  A. Araujo,et al.  Testosterone, Sex Hormone–Binding Globulin, and Frailty in Older Men , 2007, Journal of the American Geriatrics Society.

[5]  T. Travison,et al.  The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men. , 2007, The Journal of clinical endocrinology and metabolism.

[6]  R. Tremblay,et al.  Adding to the controversy: Pitfalls in the diagnosis of testosterone deficiency syndromes with questionnaires and biochemistry , 2007, The aging male : the official journal of the International Society for the Study of the Aging Male.

[7]  D. Coplen The Validity of a Single-Question Self-Report of Erectile Dysfunction: Results From the Massachusetts Male Aging Study , 2006 .

[8]  E. Nieschlag,et al.  Association of specific symptoms and metabolic risks with serum testosterone in older men. , 2006, The Journal of clinical endocrinology and metabolism.

[9]  Frederick C W Wu,et al.  Making a diagnosis of androgen deficiency in adult men: what to do until all the facts are in? , 2006, Nature Clinical Practice Endocrinology &Metabolism.

[10]  J. Mckinlay,et al.  The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study. , 2006, European journal of endocrinology.

[11]  T. Travison,et al.  The relationship between libido and testosterone levels in aging men. , 2006, The Journal of clinical endocrinology and metabolism.

[12]  V. Montori,et al.  Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. , 2006, The Journal of clinical endocrinology and metabolism.

[13]  S. Cummings,et al.  Testosterone and estradiol among older men. , 2006, The Journal of clinical endocrinology and metabolism.

[14]  H. Perry,et al.  Comparison of screening questionnaires for the diagnosis of hypogonadism. , 2006, Maturitas.

[15]  J. Kaufman,et al.  The decline of androgen levels in elderly men and its clinical and therapeutic implications. , 2005, Endocrine reviews.

[16]  SM Harman,et al.  Testosterone in older men after the Institute of Medicine Report: where do we go from here? , 2005, Climacteric : the journal of the International Menopause Society.

[17]  J. Mckinlay,et al.  Normal, bound and nonbound testosterone levels in normally ageing men: results from the Massachusetts Male Ageing Study , 2005, Clinical endocrinology.

[18]  D. Klein,et al.  AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function. , 2004, The Journal of clinical endocrinology and metabolism.

[19]  A. Araujo,et al.  Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study. , 2004, The Journal of clinical endocrinology and metabolism.

[20]  F. Saad,et al.  Can results of the Aging Males' Symptoms (AMS) scale predict those of screening scales for androgen deficiency? , 2004, The aging male : the official journal of the International Society for the Study of the Aging Male.

[21]  A. Morton Androgen deficiency and replacement therapy in men , 2004, The Medical journal of Australia.

[22]  David Handelsman,et al.  Blood testosterone threshold for androgen deficiency symptoms. , 2004, The Journal of clinical endocrinology and metabolism.

[23]  A. Araujo,et al.  The health of normally aging men: The Massachusetts Male Aging Study (1987–2004) , 2004, Experimental Gerontology.

[24]  David Handelsman,et al.  11: Androgen deficiency and replacement therapy in men , 2004, The Medical journal of Australia.

[25]  A. Morales,et al.  Andropause (or symptomatic late-onset hypogonadism): facts, fiction and controversies , 2004, The aging male : the official journal of the International Society for the Study of the Aging Male.

[26]  W. Fraser,et al.  Diurnal rhythms of serum total, free and bioavailable testosterone and of SHBG in middle‐aged men compared with those in young men , 2003, Clinical endocrinology.

[27]  H. Perry,et al.  Evaluation of assays available to measure free testosterone. , 2002, Metabolism: clinical and experimental.

[28]  A. Araujo,et al.  Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. , 2002, The Journal of clinical endocrinology and metabolism.

[29]  A. Araujo,et al.  Testosterone level, androgen receptor polymorphism, and depressive symptoms in middle-aged men , 2001, Biological Psychiatry.

[30]  E. Metter,et al.  Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. , 2001, The Journal of clinical endocrinology and metabolism.

[31]  H. Perry,et al.  Validation of a screening questionnaire for androgen deficiency in aging males. , 2000, Metabolism: clinical and experimental.

[32]  A. Vermeulen,et al.  A critical evaluation of simple methods for the estimation of free testosterone in serum. , 1999, The Journal of clinical endocrinology and metabolism.

[33]  P J Garry,et al.  Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. , 1997, Metabolism: clinical and experimental.

[34]  S. Crawford,et al.  Does collecting repeated blood samples from each subject improve the precision of estimated steroid hormone levels? , 1996, Journal of clinical epidemiology.

[35]  J. Goméz,et al.  Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men. , 1994, The Journal of clinical endocrinology and metabolism.

[36]  J. Mckinlay,et al.  Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. , 1991, The Journal of clinical endocrinology and metabolism.

[37]  Stefan Sperlich,et al.  Generalized Additive Models , 2014 .

[38]  T. Bäckström,et al.  Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. , 1982, Journal of steroid biochemistry.

[39]  P. D. Farber,et al.  A profile instrument for the quantification and assessment of alcohol consumption. The Khavari Alcohol Test. , 1978, Journal of studies on alcohol.

[40]  A. Lilienfeld The distribution of disease in the population. , 1960, Journal of chronic diseases.

[41]  T. Travison,et al.  A population-level decline in serum testosterone levels in American men. , 2007, The Journal of clinical endocrinology and metabolism.

[42]  J. Kaufman,et al.  Part of the interindividual variation in serum testosterone levels in healthy men reflects differences in androgen sensitivity and feedback set point: contribution of the androgen receptor polyglutamine tract polymorphism. , 2007, The Journal of clinical endocrinology and metabolism.

[43]  A. Lenzi,et al.  Risk factors for androgen decline in older males: lifestyle, chronic diseases and drugs. , 2005, Journal of endocrinological investigation.

[44]  M. Schubert,et al.  Late-onset hypogonadism in the aging male (LOH): definition, diagnostic and clinical aspects. , 2005, Journal of endocrinological investigation.

[45]  L. Ferrucci,et al.  The hormonal pathway to frailty in older men. , 2005, Journal of endocrinological investigation.

[46]  Göran Broström,et al.  Generalized linear models with random intercepts , 2003 .

[47]  J. Mckinlay,et al.  A new surrogate variable for erectile dysfunction status in the Massachusetts male aging study. , 2000, Journal of clinical epidemiology.

[48]  Kenneth Lange,et al.  Numerical analysis for statisticians , 1999 .

[49]  J. Mckinlay,et al.  An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis. , 1991, Journal of clinical epidemiology.

[50]  H. Akaike,et al.  Information Theory and an Extension of the Maximum Likelihood Principle , 1973 .

[51]  L. Radloff The CES-D Scale: A Self-Report Depression Scale for Research in the General Population — Source link , 2022 .