Inhibitor Development and Activated Factor VIII in Concentrates

Gtinter Mertes, Michael Ludwigl, Rainer Schwaab, Hans-Hermann Brackmann, and Klaus Olekl Dept. of Exp. Haemat. and Transf. Med., and lDept. of Clin. Biochem., Lfniversity of Bonn, Bonn, Germany 3. Ginsburg D, Sadler JEVon Willebrand disease: A database of point mutations, insertions, and deletions. Thromb Haemostas L993; 69: 177-84. 4. Zhang ZP, Falk G, Blombiick M, Egberg N, Anvret M. A single cytosine deletion in exon 18 of the von Willebrand factor gene is the most common mutation in Swedish vWD type III patients. Hum Mol Gen L992;1: 767-88. 5. Faber JR Poller W, Olek K, Baumann Lr, Carlson J, Lindmark B, Eriksson S.: The molecular basis of u1-antichymotrypsin deficiency in a heterozygote with liver and lung disease. J Hepatol L993 (in press). 6. Mertes G, Ludwig M, Schwaab R, Brackmann H-H, Olek K: TIC polymorphism in the von Willebrand factor (uWF) gene at codon 795. Hum Mol Gen L993 (submitted).