Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion
暂无分享,去创建一个
Alain Beck | A. Beck | Daniel Ayoub | N. Corvaïa | Elsa Wagner-Rousset | Daniel Ayoub | Olivier Colas | Jean-François Haeuw | Nathalie Corvaïa | Marie-Claire Janin-Bussat | Melissa Excoffier | Ian Rilatt | Michel Perez | Olivier Colas | Elsa Wagner-Rousset | Marie-Claire Janin-Bussat | J. Haeuw | Michel Perez | Mélissa Excoffier | Ian Rilatt
[1] A. Beck,et al. Fourth World Antibody-Drug Conjugate Summit , 2012, mAbs.
[2] Christian Bailly,et al. The next generation of antibody-drug conjugates comes of age. , 2010, Discovery medicine.
[3] M. Dorywalska,et al. Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates. , 2013, Chemistry & biology.
[4] P. Carter,et al. 8(th) Annual European Antibody Congress 2012: November 27-28, 2012, Geneva, Switzerland. , 2013, mAbs.
[5] W. J. Galush,et al. Profiling antibody drug conjugate positional isomers: a system-of-equations approach. , 2012, Analytical chemistry.
[6] L. Björck,et al. Enzymatic characterization of the streptococcal endopeptidase, IdeS, reveals that it is a cysteine protease with strict specificity for IgG cleavage due to exosite binding. , 2004, Biochemistry.
[7] S. Alley,et al. Analytical and bioanalytical technologies for characterizing antibody-drug conjugates. , 2013, Current opinion in chemical biology.
[8] William Bauta,et al. Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody–drug conjugates , 2012, Cancer Chemotherapy and Pharmacology.
[9] Peter G Schultz,et al. Synthesis of site-specific antibody-drug conjugates using unnatural amino acids , 2012, Proceedings of the National Academy of Sciences.
[10] Christian Bailly,et al. Strategies and challenges for the next generation of therapeutic antibodies , 2010, Nature Reviews Immunology.
[11] Aditya A Wakankar,et al. Analytical methods for physicochemical characterization of antibody drug conjugates , 2011, mAbs.
[12] François Debaene,et al. Analytical characterization of biosimilar antibodies and Fc-fusion proteins , 2013 .
[13] P. Burke,et al. A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology. , 2013, Bioconjugate chemistry.
[14] P. Parren,et al. In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap , 2013, mAbs.
[15] Paul Polakis,et al. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index , 2008, Nature Biotechnology.
[16] A. Beck,et al. World Antibody Drug Conjugate Summit Europe , 2011, mAbs.
[17] John F. Valliere-Douglass,et al. Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues. , 2012, Analytical chemistry.
[18] M. Sliwkowski,et al. Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer , 2011, Breast Cancer Research and Treatment.
[19] D. Suckau,et al. Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques , 2013, mAbs.
[20] Michael M C Sun,et al. Reduction-alkylation strategies for the modification of specific monoclonal antibody disulfides. , 2005, Bioconjugate chemistry.
[21] W. Atkins,et al. Impact of linker and conjugation chemistry on antigen binding, Fc receptor binding and thermal stability of model antibody-drug conjugates , 2012, mAbs.
[22] Huijuan Li,et al. Rapid Fc glycosylation analysis of Fc fusions with IdeS and liquid chromatography mass spectrometry , 2013, mAbs.
[23] T. Wurch,et al. Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteins. , 2008, Current pharmaceutical biotechnology.
[24] R. Huber,et al. Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[25] Asher Mullard,et al. Maturing antibody–drug conjugate pipeline hits 30 , 2013, Nature Reviews Drug Discovery.
[26] I. Bernstein,et al. SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML. , 2013, Blood.
[27] A. Beck. Glycosylation Engineering of Biopharmaceuticals , 2013, Methods in Molecular Biology.
[28] Alain Van Dorsselaer,et al. Characterization of therapeutic antibodies and related products. , 2013, Analytical chemistry.
[29] Sheng Yin,et al. Development of a native nanoelectrospray mass spectrometry method for determination of the drug-to-antibody ratio of antibody-drug conjugates. , 2013, Analytical chemistry.
[30] A. Beck,et al. Cetuximab Fab and Fc N-glycan fast characterization using IdeS digestion and liquid chromatography coupled to electrospray ionization mass spectrometry. , 2013, Methods in molecular biology.
[31] N. Bihoreau,et al. Fast analysis of recombinant monoclonal antibodies using IdeS proteolytic digestion and electrospray mass spectrometry. , 2011, Analytical biochemistry.
[32] Hongcheng Liu,et al. Ranking the susceptibility of disulfide bonds in human IgG1 antibodies by reduction, differential alkylation, and LC-MS analysis. , 2010, Analytical chemistry.
[33] M. Sliwkowski,et al. Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates , 2012, Nature Biotechnology.
[34] L. Björck,et al. IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G , 2002, The EMBO journal.