Improved complex spectral domain OCT for in vivo eye imaging

Complex Spectral domain Optical Coherence Tomography (CSdOCT) increases twice the depth of imaging in comparison with SdOCT by suppressing one of the mirror images. We present a new method of data processing, which further reduces the residual mirror images in CSdOCT. The method takes into account object movements, always present in experiments in vivo, which introduce unpredictable phase shifts. The method is free of polychromatic phase error originating from the wavelength dependence of the phase shift introduced by the reference mirror translation. Tomograms of the anterior chamber of the human eye in vivo are chosen to demonstrate a potential of the technique.

[1]  Changhuei Yang,et al.  Instantaneous quadrature low coherence interferometry with 3 x 3 fiber optic couplers , 2003, Conference on Lasers and Electro-Optics, 2003. CLEO '03..

[2]  A. Fercher,et al.  Performance of fourier domain vs. time domain optical coherence tomography. , 2003, Optics express.

[3]  A. Fercher,et al.  Measurement of intraocular distances by backscattering spectral interferometry , 1995 .

[4]  Maciej Wojtkowski,et al.  Complex spectral OCT in human eye imaging in vivo , 2004 .

[5]  Changhuei Yang,et al.  Sensitivity advantage of swept source and Fourier domain optical coherence tomography. , 2003, Optics express.

[6]  A. Fercher,et al.  In vivo human retinal imaging by Fourier domain optical coherence tomography. , 2002, Journal of biomedical optics.

[7]  C. M. Reeves,et al.  Function minimization by conjugate gradients , 1964, Comput. J..

[8]  B. Bouma,et al.  Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. , 2003, Optics letters.

[9]  G. Ha Usler,et al.  "Coherence radar" and "spectral radar"-new tools for dermatological diagnosis. , 1998, Journal of biomedical optics.

[10]  Martin T. Hagan,et al.  Neural network design , 1995 .

[11]  Adolf Friedrich Fercher,et al.  Three-dimensional ophthalmic optical coherence tomography with a refraction correction algorithm , 2003, European Conference on Biomedical Optics.

[12]  A. Fercher,et al.  Phase-shifting algorithm to achieve high-speed long-depth-range probing by frequency-domain optical coherence tomography. , 2003, Optics letters.

[13]  Maciej Wojtkowski,et al.  Complex spectral interferometry OCT , 1998, European Conference on Biomedical Optics.

[14]  A. Fercher,et al.  Full range complex spectral optical coherence tomography technique in eye imaging. , 2002, Optics letters.