Changes in working memory brain activity and task-based connectivity after long-duration spaceflight.

We studied the longitudinal effects of approximately 6 months of spaceflight on brain activity and task-based connectivity during a spatial working memory (SWM) task. We further investigated whether any brain changes correlated with changes in SWM performance from pre- to post-flight. Brain activity was measured using functional magnetic resonance imaging while astronauts (n = 15) performed a SWM task. Data were collected twice pre-flight and 4 times post-flight. No significant effects on SWM performance or brain activity were found due to spaceflight; however, significant pre- to post-flight changes in brain connectivity were evident. Superior occipital gyrus showed pre- to post-flight reductions in task-based connectivity with the rest of the brain. There was also decreased connectivity between the left middle occipital gyrus and the left parahippocampal gyrus, left cerebellum, and left lateral occipital cortex during SWM performance. These results may reflect increased visual network modularity with spaceflight. Further, increased visual and visuomotor connectivity were correlated with improved SWM performance from pre- to post-flight, while decreased visual and visual-frontal cortical connectivity were associated with poorer performance post-flight. These results suggest that while SWM performance remains consistent from pre- to post-flight, underlying changes in connectivity among supporting networks suggest both disruptive and compensatory alterations due to spaceflight.

[1]  Steven Laureys,et al.  Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight , 2022, Frontiers in Neural Circuits.

[2]  Jessica K. Lee,et al.  Head-Down-Tilt Bed Rest With Elevated CO2: Effects of a Pilot Spaceflight Analog on Neural Function and Performance During a Cognitive-Motor Dual Task , 2021, Frontiers in Physiology.

[3]  P. Reuter-Lorenz,et al.  Brain and Behavioral Evidence for Reweighting of Vestibular Inputs with Long-Duration Spaceflight. , 2021, Cerebral cortex.

[4]  A. Stahn,et al.  Brains in space: the importance of understanding the impact of long-duration spaceflight on spatial cognition and its neural circuitry , 2021, Cognitive Processing.

[5]  P. Reuter-Lorenz,et al.  The Effects of Long Duration Spaceflight on Sensorimotor Control and Cognition , 2021, bioRxiv.

[6]  Jessica K. Lee,et al.  Visuomotor Adaptation Brain Changes During a Spaceflight Analog With Elevated Carbon Dioxide (CO2): A Pilot Study , 2021, Frontiers in Neural Circuits.

[7]  G. Cheron,et al.  Persistent deterioration of visuospatial performance in spaceflight , 2021, Scientific Reports.

[8]  R. Gur,et al.  Effects of Head-Down Tilt Bed Rest Plus Elevated CO2 on Cognitive Performance. , 2021, Journal of applied physiology.

[9]  Michele T. Diaz,et al.  Age-related differences in resting-state and task-based network characteristics and cognition: a lifespan sample , 2020, Neurobiology of Aging.

[10]  Ajitkumar P. Mulavara,et al.  Brain connectivity and behavioral changes in a spaceflight analog environment with elevated CO2 , 2020, NeuroImage.

[11]  P. Reuter-Lorenz,et al.  Microgravity effects on the human brain and behavior: Dysfunction and adaptive plasticity , 2020, Neuroscience & Biobehavioral Reviews.

[12]  Stefan Kambiz Behfar,et al.  Graph Theory Analysis Reveals Resting-State Compensatory Mechanisms in Healthy Aging and Prodromal Alzheimer’s Disease , 2020, Frontiers in Aging Neuroscience.

[13]  Jessica K. Lee,et al.  Ophthalmic changes in a spaceflight analog are associated with brain functional reorganization , 2020, bioRxiv.

[14]  I. Kozlovskaya,et al.  Macro- and microstructural changes in cosmonauts’ brains after long-duration spaceflight , 2020, Science Advances.

[15]  Jessica K. Lee,et al.  Neural Working Memory Changes During a Spaceflight Analog With Elevated Carbon Dioxide: A Pilot Study , 2020, Frontiers in Systems Neuroscience.

[16]  Jessica K. Lee,et al.  The Impact of 6 and 12 Months in Space on Human Brain Structure and Intracranial Fluid Shifts , 2020, Cerebral cortex communications.

[17]  William H Paloski,et al.  Challenges to the central nervous system during human spaceflight missions to Mars. , 2020, Journal of neurophysiology.

[18]  Stephan F. Taylor,et al.  Network segregation varies with neural distinctiveness in sensorimotor cortex , 2020, NeuroImage.

[19]  N. Mammarella.  The Effect of Microgravity-Like Conditions on High-Level Cognition: A Review , 2020, Frontiers in Astronomy and Space Sciences.

[20]  P. Reuter-Lorenz,et al.  Neural Dedifferentiation across the Lifespan in the Motor and Somatosensory Systems. , 2020, Cerebral cortex.

[21]  Jessica K. Lee,et al.  Neural Correlates of Vestibular Processing During a Spaceflight Analog With Elevated Carbon Dioxide (CO2): A Pilot Study , 2020, Frontiers in Systems Neuroscience.

[22]  H. Gunga,et al.  Brain Changes in Response to Long Antarctic Expeditions. , 2019, The New England journal of medicine.

[23]  Jessica K. Lee,et al.  Head Down Tilt Bed Rest Plus Elevated CO2 as a Spaceflight Analog: Effects on Cognitive and Sensorimotor Performance , 2019, Front. Hum. Neurosci..

[24]  Steven Laureys,et al.  Alterations of Functional Brain Connectivity After Long-Duration Spaceflight as Revealed by fMRI , 2019, Front. Physiol..

[25]  Francine E. Garrett-Bakelman,et al.  The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight , 2019, Science.

[26]  Ajitkumar P. Mulavara,et al.  Spaceflight-Associated Brain White Matter Microstructural Changes and Intracranial Fluid Redistribution , 2019, JAMA neurology.

[27]  Don A. Yungher,et al.  Long-duration spaceflight adversely affects post-landing operator proficiency , 2019, Scientific Reports.

[28]  Stephan F. Taylor,et al.  Sensorimotor network segregation declines with age and is linked to GABA and to sensorimotor performance , 2019, NeuroImage.

[29]  M. Reschke,et al.  Critical Role of Somatosensation in Postural Control Following Spaceflight: Vestibularly Deficient Astronauts Are Not Able to Maintain Upright Stance During Compromised Somatosensation , 2018, Front. Physiol..

[30]  P. Reuter-Lorenz,et al.  Vestibular brain changes within 70 days of head down bed rest , 2018, Human brain mapping.

[31]  Davud Asemani,et al.  Effects of Spaceflight on Astronaut Brain Structure as Indicated on MRI , 2017, The New England journal of medicine.

[32]  P. Reuter-Lorenz,et al.  Brain plasticity and sensorimotor deterioration as a function of 70 days head down tilt bed rest , 2017, PloS one.

[33]  P. Reuter-Lorenz,et al.  Intracranial Fluid Redistribution But No White Matter Microstructural Changes During a Spaceflight Analog , 2017, Scientific Reports.

[34]  M. Mallar Chakravarty,et al.  CERES: A new cerebellum lobule segmentation method , 2017, NeuroImage.

[35]  J. Bloomberg,et al.  Brain structural plasticity with spaceflight , 2016, npj Microgravity.

[36]  M. Petieau,et al.  “Cerebellar contribution to visuo-attentional alpha rhythm: insights from weightlessness” , 2016, Scientific Reports.

[37]  S. Moore,et al.  Decreased otolith-mediated vestibular response in 25 astronauts induced by long-duration spaceflight. , 2016, Journal of neurophysiology.

[38]  Alan C. Evans,et al.  Role of the parahippocampal cortex in memory for the configuration but not the identity of objects: converging evidence from patients with selective thermal lesions and fMRI , 2015, Front. Hum. Neurosci..

[39]  Ikuko Mukai,et al.  A role of right middle frontal gyrus in reorienting of attention: a case study , 2015, Front. Syst. Neurosci..

[40]  Gabriel G. de la Torre.  Cognitive Neuroscience in Space , 2014, Life.

[41]  Millennia Foy,et al.  Relationship Between Carbon Dioxide Levels and Reported Headaches on the International Space Station , 2014, Journal of occupational and environmental medicine.

[42]  Russell E. Jackson,et al.  Visual field dependence as a navigational strategy , 2014, Attention, perception & psychophysics.

[43]  Ana-Maria Cebolla,et al.  Gravity Influences Top-Down Signals in Visual Processing , 2014, PloS one.

[44]  Stefan Maderwald,et al.  Involvement of the cerebellar cortex and nuclei in verbal and visuospatial working memory: A 7T fMRI study , 2012, NeuroImage.

[45]  Susan L. Whitfield-Gabrieli,et al.  Conn: A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks , 2012, Brain Connect..

[46]  Sterling C. Johnson,et al.  A generalized form of context-dependent psychophysiological interactions (gPPI): A comparison to standard approaches , 2012, NeuroImage.

[47]  Ajitkumar P. Mulavara,et al.  Gait adaptability training is affected by visual dependency , 2012, Experimental Brain Research.

[48]  Maolin Qiu,et al.  A whole-brain voxel based measure of intrinsic connectivity contrast reveals local changes in tissue connectivity with anesthetic without a priori assumptions on thresholds or regions of interest , 2011, NeuroImage.

[49]  Arno Klein,et al.  A reproducible evaluation of ANTs similarity metric performance in brain image registration , 2011, NeuroImage.

[50]  Otmar Bock,et al.  Cognitive demand of human sensorimotor performance during an extended space mission: a dual-task study. , 2010, Aviation, space, and environmental medicine.

[51]  Rachael D. Seidler,et al.  Contributions of Spatial Working Memory to Visuomotor Learning , 2010, Journal of Cognitive Neuroscience.

[52]  S. Moore,et al.  Effects of head-down bed rest and artificial gravity on spatial orientation , 2010, Experimental Brain Research.

[53]  Rachael D. Seidler,et al.  Frontiers in Systems Neuroscience Systems Neuroscience , 2022 .

[54]  Jörn Diedrichsen,et al.  A probabilistic MR atlas of the human cerebellum , 2009, NeuroImage.

[55]  Stephen M. Smith,et al.  Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference , 2009, NeuroImage.

[56]  G. Cheron,et al.  Effect of gravity on human spontaneous 10-Hz electroencephalographic oscillations during the arrest reaction , 2006, Brain Research.

[57]  Jörn Diedrichsen,et al.  A spatially unbiased atlas template of the human cerebellum , 2006, NeuroImage.

[58]  Nick Kanas,et al.  Space Psychology and Psychiatry , 2003 .

[59]  Edward E. Smith,et al.  Age Differences in the Frontal Lateralization of Verbal and Spatial Working Memory Revealed by PET , 2000, Journal of Cognitive Neuroscience.

[60]  D. Manzey,et al.  Mental performance during short-term and long-term spaceflight , 1998, Brain Research Reviews.

[61]  Bernd Lorenz,et al.  Dual-Task Performance in Space: Results from a Single-Case Study during a Short-Term Space Mission , 1995, Hum. Factors.

[62]  M F Reschke,et al.  Vestibular plasticity following orbital spaceflight: recovery from postflight postural instability. , 1995, Acta oto-laryngologica. Supplementum.

[63]  M F Reschke,et al.  Recovery of Postural Equilibrium Control following Spaceflight a , 1992, Annals of the New York Academy of Sciences.

[64]  D. Metzler,et al.  Mental rotation: effects of dimensionality of objects and type of task. , 1988, Journal of experimental psychology. Human perception and performance.

[65]  R. Shepard,et al.  Mental Rotation of Three-Dimensional Objects , 1971, Science.