The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling.

[1]  Minghua Li,et al.  Differential role of SH2-B and APS in regulating energy and glucose homeostasis. , 2006, Endocrinology.

[2]  R. Norton,et al.  The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. , 2006, Molecular cell.

[3]  Carol Beth Post,et al.  Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase. , 2006, Journal of molecular biology.

[4]  Sheila M. Thomas,et al.  An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival. , 2006, Developmental cell.

[5]  Karen E. Pilcher,et al.  The Dictyostelium Kinome—Analysis of the Protein Kinases from a Simple Model Organism , 2006, PLoS genetics.

[6]  R. Siebert,et al.  Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma , 2006, Leukemia.

[7]  Gavin MacBeath,et al.  A quantitative protein interaction network for the ErbB receptors using protein microarrays , 2006, Nature.

[8]  S. Hubbard,et al.  Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. , 2005, Molecular cell.

[9]  Ivan Dikic,et al.  Ubiquitylation and cell signaling , 2005, The EMBO journal.

[10]  S. Latour,et al.  Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor , 2005, Nature Immunology.

[11]  P. Heinrich,et al.  The Jak1 SH2 Domain Does Not Fulfill a Classical SH2 Function in Jak/STAT Signaling but Plays a Structural Role for Receptor Interaction and Up-regulation of Receptor Surface Expression* , 2005, Journal of Biological Chemistry.

[12]  S. Hubbard,et al.  Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins* , 2005, Journal of Biological Chemistry.

[13]  David L. Steffen,et al.  The genome of the social amoeba Dictyostelium discoideum , 2005, Nature.

[14]  R. Fischer,et al.  Peptide microarrays for the detection of molecular interactions in cellular signal transduction , 2005, Proteomics.

[15]  Mario Cazzola,et al.  A gain-of-function mutation of JAK2 in myeloproliferative disorders. , 2005, The New England journal of medicine.

[16]  Stefan N. Constantinescu,et al.  A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera , 2005, Nature.

[17]  C. Benes,et al.  The C2 Domain of PKCδ Is a Phosphotyrosine Binding Domain , 2005, Cell.

[18]  R. Pomès,et al.  The Sulfogalactose Moiety of Sulfoglycosphingolipids Serves as a Mimic of Tyrosine Phosphate in Many Recognition Processes , 2005, Journal of Biological Chemistry.

[19]  J. Kere,et al.  Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. , 2005, American journal of human genetics.

[20]  Kazuya Machida,et al.  The SH2 domain: versatile signaling module and pharmaceutical target. , 2005, Biochimica et biophysica acta.

[21]  G. Yancopoulos,et al.  Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity , 2005, Nature Medicine.

[22]  Sompop Bencharit,et al.  Structural and evolutionary division of phosphotyrosine binding (PTB) domains. , 2005, Journal of molecular biology.

[23]  Bruce Tidor,et al.  A computational method for the analysis and prediction of protein:phosphopeptide‐binding sites , 2005, Protein science : a publication of the Protein Society.

[24]  Tatiana A. Tatusova,et al.  Entrez Gene: gene-centered information at NCBI , 2004, Nucleic Acids Res..

[25]  Cathy H. Wu,et al.  The Universal Protein Resource (UniProt) , 2004, Nucleic Acids Res..

[26]  John D. Minna,et al.  Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia , 2004, Cancer Research.

[27]  R. Rottapel,et al.  Regulation of the immune system by SOCS family adaptor proteins. , 2004, Seminars in immunology.

[28]  W. Alexander,et al.  Development of hydrocephalus in mice lacking SOCS7. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[29]  M. White,et al.  Disruption of the SH2-B Gene Causes Age-Dependent Insulin Resistance and Glucose Intolerance , 2004, Molecular and Cellular Biology.

[30]  M. Mann,et al.  Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics , 2004, Nature Biotechnology.

[31]  W. Alexander,et al.  SOCS5 Is Expressed in Primary B and T Lymphoid Cells but Is Dispensable for Lymphocyte Production and Function , 2004, Molecular and Cellular Biology.

[32]  T. Watts,et al.  Immune Functions in Mice Lacking Clnk, an SLP-76-Related Adaptor Expressed in a Subset of Immune Cells , 2004, Molecular and Cellular Biology.

[33]  Joanna M. Sasin,et al.  Protein Tyrosine Phosphatases in the Human Genome , 2004, Cell.

[34]  Rui Xu,et al.  Construction of A Non-Redundant Human SH2 Domain Database , 2004, Genomics, proteomics & bioinformatics.

[35]  S. Pandit,et al.  SUPFAM: A database of sequence superfamilies of protein domains , 2004, BMC Bioinformatics.

[36]  Y. Kataoka,et al.  Increased Numbers of B-1 Cells and Enhanced Responses against TI-2 Antigen in Mice Lacking APS, an Adaptor Molecule Containing PH and SH2 Domains , 2004, Molecular and Cellular Biology.

[37]  David E James,et al.  Improved glucose homeostasis and enhanced insulin signalling in Grb14‐deficient mice , 2004, The EMBO journal.

[38]  B. Mayer,et al.  Inducible Clustering of Membrane-Targeted SH3 Domains of the Adaptor Protein Nck Triggers Localized Actin Polymerization , 2004, Current Biology.

[39]  Toshiyuki Fukada,et al.  A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[40]  Gregory D. Schuler,et al.  Database resources of the National Center for Biotechnology Information: update , 2004, Nucleic acids research.

[41]  S. Emr,et al.  Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S. , 2003, Molecular biology of the cell.

[42]  S. Hubbard,et al.  Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. , 2003, Molecular cell.

[43]  Miikka Vikkula,et al.  Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations. , 2003, American journal of human genetics.

[44]  F. Alt,et al.  Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells , 2003, The Journal of experimental medicine.

[45]  R. Khokha,et al.  Cbl-3-Deficient Mice Exhibit Normal Epithelial Development , 2003, Molecular and Cellular Biology.

[46]  Y. Nakaya,et al.  Increased insulin sensitivity and hypoinsulinemia in APS knockout mice. , 2003, Diabetes.

[47]  G. Inghirami,et al.  The B Cell SH2/PH Domain-Containing Adaptor Bam32/DAPP1 Is Required for T Cell-Independent II Antigen Responses , 2003, Current Biology.

[48]  M. Nussenzweig,et al.  Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival. , 2003, Immunity.

[49]  P. Fields,et al.  T cell development and function in CrkL‐deficient mice , 2003, European journal of immunology.

[50]  B. Little,et al.  Growth hormone insensitivity associated with a STAT5b mutation. , 2003, The New England journal of medicine.

[51]  Tony Pawson,et al.  Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[52]  S. Carroll,et al.  Evolution of Key Cell Signaling and Adhesion Protein Families Predates Animal Origins , 2003, Science.

[53]  Joseph Schlessinger,et al.  SH2 and PTB Domains in Tyrosine Kinase Signaling , 2003, Science's STKE.

[54]  T. Pawson,et al.  The Murine Nck SH2/SH3 Adaptors Are Important for the Development of Mesoderm-Derived Embryonic Structures and for Regulating the Cellular Actin Network , 2003, Molecular and Cellular Biology.

[55]  Michael B. Yaffe,et al.  Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs , 2003, Nucleic Acids Res..

[56]  Florentia M. Smith,et al.  Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[57]  Jen-Fen Fu,et al.  Identification of CBL, a proto‐oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia , 2003, Genes, chromosomes & cancer.

[58]  J. Licht,et al.  Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia , 2003, Nature Genetics.

[59]  M. Schrappe,et al.  Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia , 2003, Nature.

[60]  S. Hubbard,et al.  Structural Basis for Dimerization of the Grb10 Src Homology 2 Domain , 2003, The Journal of Biological Chemistry.

[61]  D. Ledbetter,et al.  Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3. , 2003, American journal of human genetics.

[62]  S. Minoguchi,et al.  STAP-2/BKS, an Adaptor/Docking Protein, Modulates STAT3 Activation in Acute-phase Response through Its YXXQ Motif* , 2003, The Journal of Biological Chemistry.

[63]  G. Superti-Furga,et al.  Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase , 2003, Cell.

[64]  Blagoy Blagoev,et al.  A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling , 2003, Nature Biotechnology.

[65]  B. Neel,et al.  The "Gab" in signal transduction. , 2003, Trends in cell biology.

[66]  P. Schwartzberg,et al.  Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation , 2003, Nature Cell Biology.

[67]  Alcino J. Silva,et al.  The RAS Effector RIN1 Modulates the Formation of Aversive Memories , 2003, The Journal of Neuroscience.

[68]  R. Ahmed,et al.  SAP is required for generating long-term humoral immunity , 2003, Nature.

[69]  T. Hunter,et al.  The Protein Kinase Complement of the Human Genome , 2002, Science.

[70]  M. Naramura,et al.  c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation , 2002, Nature Immunology.

[71]  Tony Pawson,et al.  Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[72]  L. Buday,et al.  The Nck family of adapter proteins: regulators of actin cytoskeleton. , 2002, Cellular signalling.

[73]  Alex Bateman,et al.  HMM-based databases in InterPro , 2002, Briefings Bioinform..

[74]  Fabrizio Giordanetto,et al.  Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7. , 2002, Protein engineering.

[75]  M. Digilio,et al.  Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene. , 2002, American journal of human genetics.

[76]  Dominique Gauguier,et al.  The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. , 2002, Diabetes.

[77]  W. Alexander,et al.  SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation , 2002, Molecular and Cellular Biology.

[78]  Edison T. Liu,et al.  Characterization of Mice Deficient in the Src Family Nonreceptor Tyrosine Kinase Frk/rak , 2002, Molecular and Cellular Biology.

[79]  T. Pawson,et al.  Cytokine Signaling and Hematopoietic Homeostasis Are Disrupted in Lnk-deficient Mice , 2002, The Journal of experimental medicine.

[80]  A. Yoshimura,et al.  SH2-B Is Required for Both Male and Female Reproduction , 2002, Molecular and Cellular Biology.

[81]  A. Alonso,et al.  Grap Negatively Regulates T-Cell Receptor-Elicited Lymphocyte Proliferation and Interleukin-2 Induction , 2002, Molecular and Cellular Biology.

[82]  M. Yaffe.  Phosphotyrosine-binding domains in signal transduction , 2002, Nature Reviews Molecular Cell Biology.

[83]  Kohjiro Ueki,et al.  Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[84]  Michael A. Patton,et al.  Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome , 2001, Nature Genetics.

[85]  T Pawson,et al.  SH2 domains, interaction modules and cellular wiring. , 2001, Trends in cell biology.

[86]  B. Mayer,et al.  Profiling the global tyrosine phosphorylation state by Src homology 2 domain binding , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[87]  S. Feller.  Crk family adaptors–signalling complex formation and biological roles , 2001, Oncogene.

[88]  A. Weiss,et al.  The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. , 2001, Immunity.

[89]  T. Pawson,et al.  Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product , 2001, Nature Immunology.

[90]  W. Alexander,et al.  Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[91]  Steven M. Holland,et al.  Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation , 2001, Science.

[92]  P. Carmeliet,et al.  Bmx Tyrosine Kinase Has a Redundant Function Downstream of Angiopoietin and Vascular Endothelial Growth Factor Receptors in Arterial Endothelium , 2001, Molecular and Cellular Biology.

[93]  A. Sher,et al.  Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[94]  M. Habal,et al.  Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism , 2001, Nature Genetics.

[95]  K. Tedford,et al.  Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling , 2001, Nature Immunology.

[96]  P. Borrow,et al.  SAP controls T cell responses to virus and terminal differentiation of TH2 cells , 2001, Nature Immunology.

[97]  M. Yaffe,et al.  A motif-based profile scanning approach for genome-wide prediction of signaling pathways , 2001, Nature Biotechnology.

[98]  R. Firtel,et al.  An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway. , 2001, Genes & development.

[99]  A. Cheng,et al.  Requirement for the SLP-76 Adaptor GADS in T Cell Development , 2001, Science.

[100]  B. Druker,et al.  Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome , 2001, Nature Genetics.

[101]  Timothy B. Stockwell,et al.  The Sequence of the Human Genome , 2001, Science.

[102]  M. Tanimoto,et al.  Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12). , 2001, Blood.

[103]  J. V. Moran,et al.  Initial sequencing and analysis of the human genome. , 2001, Nature.

[104]  R. Zirngibl,et al.  Mice Devoid of Fer Protein-Tyrosine Kinase Activity Are Viable and Fertile but Display Reduced Cortactin Phosphorylation , 2001, Molecular and Cellular Biology.

[105]  Steffen Jung,et al.  Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk , 2000, The Journal of experimental medicine.

[106]  T. Pawson,et al.  The Mammalian ShcB and ShcC Phosphotyrosine Docking Proteins Function in the Maturation of Sensory and Sympathetic Neurons , 2000, Neuron.

[107]  C. Schindler,et al.  Immune response in Stat2 knockout mice. , 2000, Immunity.

[108]  R. Perlmutter,et al.  Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. , 2000, Immunity.

[109]  M. Naujokas,et al.  Identification of an Atypical Grb2 Carboxyl-terminal SH3 Domain Binding Site in Gab Docking Proteins Reveals Grb2-dependent and -independent Recruitment of Gab1 to Receptor Tyrosine Kinases* , 2000, The Journal of Biological Chemistry.

[110]  M. Shibamori,et al.  Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. , 2000, Immunity.

[111]  H. Pircher,et al.  Partial impairment of cytokine responses in Tyk2-deficient mice. , 2000, Immunity.

[112]  M. Simon,et al.  Abnormal Stat activation, hematopoietic homeostasis, and innate immunity in c-fes-/- mice. , 2000, Immunity.

[113]  J. Cleveland,et al.  Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. , 2000, Immunity.

[114]  W. Alexander,et al.  Gigantism in mice lacking suppressor of cytokine signalling-2 , 2000, Nature.

[115]  T. Pawson,et al.  Protein-protein interactions define specificity in signal transduction. , 2000, Genes & development.

[116]  T Pawson,et al.  The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. , 2000, Genes & development.

[117]  K. Rajewsky,et al.  The B-Cell-Specific src-Family Kinase Blk Is Dispensable for B-Cell Development and Activation , 2000, Molecular and Cellular Biology.

[118]  E. Shevach,et al.  Cbl-b regulates the CD28 dependence of T-cell activation , 2000, Nature.

[119]  T. Hunter,et al.  Signaling—2000 and Beyond , 2000, Cell.

[120]  K. Yamamura,et al.  Mutant mice lacking Crk-II caused by the gene trap insertional mutagenesis: Crk-II is not essential for embryonic development. , 1999, Biochemical and biophysical research communications.

[121]  L. Kearney,et al.  The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts. , 1999, Blood.

[122]  J. Bluestone,et al.  Ribp, a Novel Rlk/Txk- and Itk-Binding Adaptor Protein That Regulates T Cell Activation , 1999, The Journal of experimental medicine.

[123]  D. Campana,et al.  An essential role for BLNK in human B cell development. , 1999, Science.

[124]  T. Pawson,et al.  Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A , 1999, Current Biology.

[125]  C Terhorst,et al.  Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. , 1999, Molecular cell.

[126]  H. Pendeville,et al.  SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis , 1999, Cell.

[127]  R. Berger,et al.  The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia. , 1999, Human molecular genetics.

[128]  H. Varmus,et al.  Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. , 1999, Science.

[129]  B. Kennedy,et al.  Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. , 1999, Science.

[130]  Michael J. Eck,et al.  Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase , 1999, Nature.

[131]  Timothy J. Yeatman,et al.  Activating SRC mutation in a subset of advanced human colon cancers , 1999, Nature Genetics.

[132]  F. Alt,et al.  Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. , 1999, Science.

[133]  Y. Yazaki,et al.  Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. , 1999, Science.

[134]  M. Naramura,et al.  Altered thymic positive selection and intracellular signals in Cbl-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[135]  Temple F. Smith,et al.  Comparison of the complete protein sets of worm and yeast: orthology and divergence. , 1998, Science.

[136]  Tony Pawson,et al.  Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation , 1998, Cell.

[137]  D. Baltimore,et al.  Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation , 1998, Neuron.

[138]  A. Elefanty,et al.  Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[139]  D. Allen,et al.  The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM , 1998, Nature.

[140]  F. Alt,et al.  Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76 , 1998, Cell.

[141]  N. Taylor,et al.  Defective expression of p56lck in an infant with severe combined immunodeficiency. , 1998, The Journal of clinical investigation.

[142]  G. Krystal,et al.  Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. , 1998, Genes & development.

[143]  J. Darnell,et al.  Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA , 1998, Cell.

[144]  Michael P. Brown,et al.  Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses , 1998, Cell.

[145]  J Schultz,et al.  SMART, a simple modular architecture research tool: identification of signaling domains. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[146]  R. Schreiber,et al.  Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses , 1998, Cell.

[147]  J. Marine,et al.  Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors , 1998, Cell.

[148]  A. Cumano,et al.  Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis , 1998, Cell.

[149]  S. Shoelson,et al.  Crystal Structure of the Tyrosine Phosphatase SHP-2 , 1998, Cell.

[150]  S. Shoelson,et al.  Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling* , 1998, The Journal of Biological Chemistry.

[151]  R Berger,et al.  A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. , 1997, Science.

[152]  P. Marynen,et al.  Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. , 1997, Blood.

[153]  T. Pawson,et al.  The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[154]  M. Mann,et al.  SH2 Signaling in a Lower Eukaryote: A STAT Protein That Regulates Stalk Cell Differentiation in Dictyostelium , 1997, Cell.

[155]  T. Pawson,et al.  Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp‐2 , 1997, The EMBO journal.

[156]  S. Akira,et al.  Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[157]  G. Carpenter,et al.  Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[158]  E. Fuchs,et al.  Progressive Kidney Degeneration in Mice Lacking Tensin , 1997, The Journal of cell biology.

[159]  L. Hennighausen,et al.  Stat5a is mandatory for adult mammary gland development and lactogenesis. , 1997, Genes & development.

[160]  A. Weiss,et al.  αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases , 1996 .

[161]  J. Livingston,et al.  Insulin Signaling in Mice Expressing Reduced Levels of Syp* , 1996, The Journal of Biological Chemistry.

[162]  M. Kaplan,et al.  Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice , 1996, Nature.

[163]  A. Iwama,et al.  Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice. , 1996, Biochemical and biophysical research communications.

[164]  D. Erdmann,et al.  Structural basis for specificity of GRB2-SH2 revealed by a novel ligand binding mode , 1996, Nature Structural Biology.

[165]  X. Chen,et al.  Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h. , 1996, Genomics.

[166]  W. Paul,et al.  Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene , 1996, Nature.

[167]  H. Varmus,et al.  Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. , 1996, Blood.

[168]  R. Schreiber,et al.  Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway , 1996, Cell.

[169]  L. Cantley,et al.  Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins , 1995, Cell.

[170]  D. Littman,et al.  Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. , 1995, Immunity.

[171]  Victor L. J. Tybulewicz,et al.  Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk , 1995, Nature.

[172]  Tony Pawson,et al.  Syk tyrosine kinase required for mouse viability and B-cell development , 1995, Nature.

[173]  W. Leonard,et al.  Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development , 1995, Science.

[174]  P. Doherty,et al.  Defective Lymphoid Development in Mice Lacking Jak3 , 1995, Science.

[175]  A. Sharpe,et al.  Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3 , 1995, Science.

[176]  T. Yamamoto,et al.  Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. , 1995, Immunity.

[177]  T. Pawson,et al.  Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein , 1995, Nature.

[178]  S. Stacker,et al.  Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease , 1995, Cell.

[179]  F. Alt,et al.  Defective B cell development and function in Btk-deficient mice. , 1995, Immunity.

[180]  R. Perlmutter,et al.  Impaired expansion of mouse B cell progenitors lacking Btk. , 1995, Immunity.

[181]  K. Nakayama,et al.  Essential role for ZAP-70 in both positive and negative selection of thymocytes , 1995, Nature.

[182]  S. Orkin,et al.  Hematopoietic development of vav-/- mouse embryonic stem cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[183]  T. Yagi,et al.  A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption , 1994, Molecular and cellular biology.

[184]  H. Vogel,et al.  Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. , 1994, Genes & development.

[185]  T. Hope,et al.  Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. , 1994, Science.

[186]  W. Kuo,et al.  ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. , 1994, Science.

[187]  T. Pawson,et al.  Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-γ1 complexed with a high affinity binding peptide , 1994, Cell.

[188]  T Pawson,et al.  Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav , 1994, Molecular and cellular biology.

[189]  A. Cohen,et al.  Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase , 1994, Cell.

[190]  H. Varmus,et al.  Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. , 1994, Genes & development.

[191]  I. Campbell,et al.  Structure of an SH2 domain of the p85α subunit of phosphatidylinositol-3-OH kinase , 1994, Nature.

[192]  T. Yagi,et al.  A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice , 1993, Nature.

[193]  Frank McCormick,et al.  Nonsense mutations in the C–terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours , 1993, Nature Genetics.

[194]  D. Baltimore,et al.  Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides , 1993, Nature.

[195]  Robert B. Russell,et al.  An SH2—SH3 domain hybrid , 1993, Nature.

[196]  D J Rawlings,et al.  Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. , 1993, Science.

[197]  D. Beier,et al.  Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene , 1993, Cell.

[198]  Philippe Soriano,et al.  Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice , 1993, Cell.

[199]  T. Yagi,et al.  Constitutive activation of Src family kinases in mouse embryos that lack Csk , 1993, Cell.

[200]  T. Pawson,et al.  The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 , 1993, Nature.

[201]  J. Kuriyan,et al.  Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms , 1993, Cell.

[202]  D. Baltimore,et al.  Three-dimensional solution structure of the src homology 2 domain of c-abl , 1992, Cell.

[203]  A. Wakeham,et al.  Profound block in thymocyte development in mice lacking p56lck , 1992, Nature.

[204]  J. Rowley,et al.  The LCK Gene Is Involved in the t(1;7)(p34;q34) in the T‐Cell Acute Lymphoblastic Leukemia Derived Cell Line, HSB‐2 , 1991, Genes, chromosomes & cancer.

[205]  R. Bronson,et al.  Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene , 1991, Cell.

[206]  S. Goff,et al.  Mice homozygous for the abl m1 mutation show poor viability and depletion of selected B and T cell populations , 1991, Cell.

[207]  Allan Bradley,et al.  Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice , 1991, Cell.

[208]  L. Shultz,et al.  Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev). , 1989, Experimental hematology.

[209]  J. Stephenson,et al.  A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia , 1982, Nature.

[210]  Somasekar Seshagiri,et al.  Somatic mutations lead to an oncogenic deletion of met in lung cancer. , 2006, Cancer research.

[211]  松山 智洋.  What's going on 造血器腫瘍 A gain-of-function mutation of JAK2 in myeloproliferative disorders. Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC. N Engl J Med. 2005; 352: 1779-90. PMID:15858187.--慢性骨髄増殖性疾患においてJAK2遺伝子の変異が高頻度にみられることを示した論文 , 2005 .

[212]  Giovanni Cesareni,et al.  Modular protein domains , 2005 .

[213]  Cathy H. Wu,et al.  UniProt: the Universal Protein knowledgebase , 2004, Nucleic Acids Res..

[214]  Jay Snoddy,et al.  BMC Bioinformatics BioMed Central Database , 2004 .

[215]  Peer Bork,et al.  SMART 4.0: towards genomic data integration , 2004, Nucleic Acids Res..

[216]  Sam A. Johnson,et al.  Kinomics: methods for deciphering the kinome , 2004, Nature Methods.

[217]  John B. Anderson,et al.  CDD: a curated Entrez database of conserved domain alignments , 2003, Nucleic Acids Res..

[218]  M. Reth,et al.  The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion , 2003, Nature Immunology.

[219]  Gabriel Waksman,et al.  Molecular recognition by SH2 domains. , 2002, Advances in protein chemistry.

[220]  Alan F. Scott,et al.  Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders , 2004, Nucleic Acids Res..

[221]  W. Pear,et al.  The SH2 domain of bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype. , 2001, Blood.

[222]  T. Takenawa,et al.  Signaling through Grb2/Ash-control of the Ras pathway and cytoskeleton. , 1998, Current topics in microbiology and immunology.

[223]  D Cowburn,et al.  Modular peptide recognition domains in eukaryotic signaling. , 1997, Annual review of biophysics and biomolecular structure.

[224]  Y. Akao,et al.  Relationship of the human protooncogene CBL2 on 11q23 to the t(4;11), t(11;22), and t(11;14) breakpoints. , 1991, Cytogenetics and cell genetics.

[225]  J. Stephenson,et al.  The human v-abl cellular homologue. , 1983, Journal of molecular and applied genetics.