Interleukin‐4‐independent production of Th2 cytokines by nasal lymphocytes and nasal eosinophilia in murine allergic rhinitis

Background: Interleukin (IL)‐4 is believed to play an important role in the atopic pathogenesis. However, the precise role of IL‐4 in the in vivo initiation of allergic rhinitis is not fully understood. We have recently found that BALB/c mice sensitized intranasally with Schistosoma mansoni egg antigen (SEA) mount a Th2 response that initiates allergic rhinitis. Thus, we sought to determine the role of IL‐4 in the initiation of allergic rhinitis in vivo with this model.

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