A Multiparameter Adjustable, Portable High-Voltage Nanosecond Pulse Generator Based on Stacked Blumlein Multilayered PCB Strip Transmission Line

Several series and parallel Blumlein-type striplines designed on multilayered printed circuit board (PCB) are connected to match different impedance loads with different pulsewidths to develop a high-voltage nanosecond pulse generator for investigating the biological effects of a nanosecond pulsed electric field. First, the principle of a multistage series-parallel Blumlein stripline system is described. In particular, the multilayered strip transmission line is designed on the five-layered PCB to minimize the volume of the system whose maximum size is 300 mm (length) × 260 mm (width) × 154 mm (height), and the gate resistor capacitor and diode active equalizing circuit is used as the dynamic/static balancing tactic. Then, a single-stage Blumlein-type stripline and some multistage series-parallel Blumlein-type stripline are established to test their performance. As a result, the nanosecond pulse generator produces a rectangular pulse on a matched resistor load, with an amplitude of 0-1.7 kV, a pulsewidth of integer multiples of 100 ns, a rise time of ~20 ns or less, and a repetition frequency of 0 to several kHz. A variety of biomedical loads can be matched by parallel stacking mode, which will facilitate the analysis of the biological effects of the nanosecond pulsed electric field.

[1]  C. Abbate,et al.  Series connection of high power IGBT modules for traction applications , 2005, 2005 European Conference on Power Electronics and Applications.

[2]  Xd Power Design of RCD Active Gate Control Circuit for Series Connected IGBTs , 2013 .

[3]  Luigi Zeni,et al.  A Blumlein-type, nanosecond pulse generator with interchangeable transmission lines for bioelectrical applications , 2013, IEEE Transactions on Dielectrics and Electrical Insulation.

[4]  K. Schoenbach,et al.  Bioelectrics-new applications for pulsed power technology , 2001, PPPS-2001 Pulsed Power Plasma Science 2001. 28th IEEE International Conference on Plasma Science and 13th IEEE International Pulsed Power Conference. Digest of Papers (Cat. No.01CH37251).

[5]  Ravindra P. Joshi,et al.  Ultrashort electrical pulses open a new gateway into biological cells , 2004 .

[6]  Mario Greule,et al.  Design Considerations for a Fast Stacked-MOSFET Switch , 2013, IEEE Transactions on Plasma Science.

[7]  J. Crowley,et al.  Electrical breakdown of bimolecular lipid membranes as an electromechanical instability. , 1973, Biophysical journal.

[8]  Heung-Geun Kim,et al.  High voltage switch using series-connected IGBTs with simple auxiliary circuit , 2000, Conference Record of the 2000 IEEE Industry Applications Conference. Thirty-Fifth IAS Annual Meeting and World Conference on Industrial Applications of Electrical Energy (Cat. No.00CH37129).

[9]  Laura Marcu,et al.  In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies , 2007, International journal of cancer.

[10]  Damijan Miklavčič,et al.  Electroporation-based technologies for medicine: principles, applications, and challenges. , 2014, Annual review of biomedical engineering.

[11]  D. H. Michael,et al.  Electrohydrodynamic instability in plane layers of fluid , 1970, Journal of Fluid Mechanics.

[12]  Richard Nuccitelli,et al.  Optimized nanosecond pulsed electric field therapy can cause murine malignant melanomas to self‐destruct with a single treatment , 2010, International journal of cancer.

[13]  Juergen F. Kolb,et al.  A new pulsed electric field therapy for melanoma disrupts the tumor's blood supply and causes complete remission without recurrence , 2009, International journal of cancer.