The MAP kinase cascade. Discovery of a new signal transduction pathway

[1]  E. Krebs,et al.  Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[2]  C. Lange-Carter,et al.  A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf , 1993, Science.

[3]  B. Errede,et al.  Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases , 1993, Molecular and cellular biology.

[4]  B. Errede,et al.  A conserved kinase cascade for MAP kinase activation in yeast. , 1993, Current opinion in cell biology.

[5]  Jonathan A. Cooper,et al.  Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro , 1993, Molecular and cellular biology.

[6]  M. Cobb,et al.  Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. , 1993, The Journal of biological chemistry.

[7]  E. Nishida,et al.  Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase. , 1993, The Journal of biological chemistry.

[8]  E. Nishida,et al.  cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates. , 1993, The EMBO journal.

[9]  A. Porras,et al.  p21ras-induced meiotic maturation of Xenopus oocytes in the absence of protein synthesis: MPF activation is preceded by activation of MAP and S6 kinases. , 1993, Oncogene.

[10]  M. Cobb,et al.  Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1 , 1993, Molecular and cellular biology.

[11]  K. Kaibuchi,et al.  A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Brian J. Stevenson,et al.  Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. , 1993, Molecular biology of the cell.

[13]  H. Michel,et al.  Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[14]  E. Krebs,et al.  Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. , 1992, The Journal of biological chemistry.

[15]  E. Krebs,et al.  The mitogen-activated protein kinase activator. , 1992, Current opinion in cell biology.

[16]  A. Ashworth,et al.  The amino acid sequence of a mammalian MAP kinase kinase. , 1992, Oncogene.

[17]  P. Cohen,et al.  MAPKAP kinase‐2; a novel protein kinase activated by mitogen‐activated protein kinase. , 1992, The EMBO journal.

[18]  C. Crews,et al.  The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. , 1992, Science.

[19]  P. Cohen,et al.  Activation of the MAP kinase pathway by the protein kinase raf , 1992, Cell.

[20]  M. Wigler,et al.  Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[21]  E. Nishida,et al.  Activation of mitogen-activated protein kinase and its activator by ras in intact cells and in a cell-free system. , 1992, The Journal of biological chemistry.

[22]  T. Haystead,et al.  Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. , 1992, Science.

[23]  C. Crews,et al.  Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[24]  B. Tocqué,et al.  Stimulation of mitogen-activated protein kinase by oncogenic Ras p21 in Xenopus oocytes. Requirement for Ras p21-GTPase-activating protein interaction. , 1992, The Journal of biological chemistry.

[25]  C. Crews,et al.  Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[26]  M. Cobb,et al.  Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[27]  E. Nishida,et al.  Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation. , 1992, The EMBO journal.

[28]  David L. Brautigan,et al.  Raf-1 activates MAP kinase-kinase , 1992, Nature.

[29]  Jonathan A. Cooper,et al.  Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. , 1992, The Journal of biological chemistry.

[30]  M. Peter,et al.  Immunological characterization of avian MAP kinases: evidence for nuclear localization. , 1992, Molecular biology of the cell.

[31]  G. Crabtree,et al.  Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases , 1992, Cell.

[32]  J. Bos,et al.  Involvement of p21ras in activation of extracellular signal-regulated kinase 2 , 1992, Nature.

[33]  T. Sturgill,et al.  The phorbol ester-dependent activator of the mitogen-activated protein kinase p42mapk is a kinase with specificity for the threonine and tyrosine regulatory sites. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Philip R. Cohen,et al.  MAP kinase activator from insulin‐stimulated skeletal muscle is a protein threonine/tyrosine kinase. , 1992, The EMBO journal.

[35]  J. Maller,et al.  Ordered multisite phosphorylation of Xenopus ribosomal protein S6 by S6 kinase II. , 1992, The Journal of biological chemistry.

[36]  T. Sturgill,et al.  Growth factor-induced activation of a kinase activity which causes regulatory phosphorylation of p42/microtubule-associated protein kinase , 1992, Molecular and cellular biology.

[37]  J. Blenis,et al.  ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK , 1992, Cell.

[38]  Sheila M. Thomas,et al.  Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases , 1992, Cell.

[39]  J. Blenis,et al.  Nuclear localization and regulation of erk- and rsk-encoded protein kinases , 1992, Molecular and cellular biology.

[40]  T. Akiyama,et al.  Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade. , 1992, The EMBO journal.

[41]  T. Hunter,et al.  Dual-specificity protein kinases: will any hydroxyl do? , 1992, Trends in biochemical sciences.

[42]  G. Thomas,et al.  Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver. , 1992, The Journal of biological chemistry.

[43]  G. Woude,et al.  Meiotic initiation by the mos protein in Xenopus , 1992, Nature.

[44]  S. Leevers,et al.  Activation of extracellular signal‐regulated kinase, ERK2, by p21ras oncoprotein. , 1992, The EMBO journal.

[45]  P. Blackshear,et al.  Evidence that extracellular signal-regulated kinases are the insulin-activated Raf-1 kinase kinases. , 1992, The Journal of biological chemistry.

[46]  Jonathan A. Cooper,et al.  Requirements for phosphorylation of MAP kinase during meiosis in Xenopus oocytes. , 1992, Science.

[47]  M. Cobb,et al.  ERKs, extracellular signal-regulated MAP-2 kinases. , 1991, Current opinion in cell biology.

[48]  E. Warbrick,et al.  The wis1 protein kinase is a dosage‐dependent regulator of mitosis in Schizosaccharomyces pombe. , 1991, The EMBO journal.

[49]  T. Sturgill,et al.  Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[50]  James R. Woodgett,et al.  Phosphorylation of c-jun mediated by MAP kinases , 1991, Nature.

[51]  C. Crews,et al.  Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[52]  T. Curran,et al.  Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. , 1991, The Journal of biological chemistry.

[53]  J. Zheng,et al.  Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. , 1991, Science.

[54]  J. Zheng,et al.  Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. , 1991, Science.

[55]  T. Roberts,et al.  Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo. , 1991, The Biochemical journal.

[56]  E. Krebs,et al.  Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[57]  M. Wigler,et al.  byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype , 1991, Molecular and cellular biology.

[58]  P. Blackshear,et al.  Evidence for one or more Raf-1 kinase kinase(s) activated by insulin and polypeptide growth factors. , 1991, The Journal of biological chemistry.

[59]  Nancy Y. Ip,et al.  ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF , 1991, Cell.

[60]  M. Cobb,et al.  Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. , 1991, Cell regulation.

[61]  R. Erikson,et al.  Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6. , 1991, The Journal of biological chemistry.

[62]  J. Shabanowitz,et al.  Identification of the regulatory phosphorylation sites in pp42/mitogen‐activated protein kinase (MAP kinase). , 1991, The EMBO journal.

[63]  J. Maller,et al.  Purification and characterization of ribosomal protein S6 kinase I from Xenopus eggs. , 1991, The Journal of biological chemistry.

[64]  E. Krebs,et al.  Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. , 1991, The Journal of biological chemistry.

[65]  W. Haser,et al.  Raf-1: A kinase currently without a cause but not lacking in effects , 1991, Cell.

[66]  G. Thomas,et al.  MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways , 1991, Nature.

[67]  J. Avruch,et al.  Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[68]  D. Sabatini,et al.  Colony stimulating factor‐1 (CSF‐1) stimulates temperature dependent phosphorylation and activation of the RAF‐1 proto‐oncogene product. , 1990, The EMBO journal.

[69]  M. Siegmann,et al.  Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[70]  E. Krebs,et al.  Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro. , 1990, The Journal of biological chemistry.

[71]  E. Krebs,et al.  Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells. , 1990, The Journal of biological chemistry.

[72]  C. Slaughter,et al.  An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. , 1990, Science.

[73]  J. Blenis,et al.  Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation , 1990, Molecular and cellular biology.

[74]  J. Maller.  Xenopus oocytes and the biochemistry of cell division. , 1990, Biochemistry.

[75]  J. Maller,et al.  Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase , 1990, Nature.

[76]  M. Cobb,et al.  An insulin-stimulated ribosomal protein S6 kinase from rabbit liver. , 1989, The Journal of biological chemistry.

[77]  T. Sturgill,et al.  Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[78]  J. Maller,et al.  In vivo phosphorylation and activation of ribosomal protein S6 kinases during Xenopus oocyte maturation. , 1989, The Journal of biological chemistry.

[79]  J. Avruch,et al.  Purification of a hepatic S6 kinase from cycloheximide-treated Rats. , 1989, The Journal of biological chemistry.

[80]  D. Morrison,et al.  Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[81]  E. Krebs,et al.  Activation of myelin basic protein kinases during echinoderm oocyte maturation and egg fertilization. , 1988, Developmental biology.

[82]  G. Woude,et al.  Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes , 1988, Nature.

[83]  M. Siegmann,et al.  S6 kinase in quiescent Swiss mouse 3T3 cells is activated by phosphorylation in response to serum treatment. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[84]  J. Maller,et al.  Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II , 1988, Nature.

[85]  T. Hunter,et al.  The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. , 1988, Science.

[86]  T. Sturgill,et al.  Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[87]  J. Blenis,et al.  A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[88]  E. Nishida,et al.  Activation of a Ca2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts. , 1988, The Journal of biological chemistry.

[89]  A. Nasim,et al.  A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast. , 1988, The EMBO journal.

[90]  E. Krebs,et al.  Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes. , 1988, The Journal of biological chemistry.

[91]  G. Thomas,et al.  Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells. , 1988, The Journal of biological chemistry.

[92]  J. Maller,et al.  Substrate specificity of ribosomal protein S6 kinase II from Xenopus eggs. , 1988, Second messengers and phosphoproteins.

[93]  J. Polazzi,et al.  Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[94]  T. Sturgill,et al.  Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[95]  M. Cobb.  An insulin-stimulated ribosomal protein S6 kinase in 3T3-L1 cells. , 1986, The Journal of biological chemistry.

[96]  B. Errede,et al.  Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[97]  E. Krebs.  1 The Enzymology of Control by Phosphorylation , 1986 .

[98]  R. Denton.  Early events in insulin actions. , 1986, Advances in cyclic nucleotide and protein phosphorylation research.

[99]  G. Thomas,et al.  Epidermal growth factor-mediated activation of an S6 kinase in Swiss mouse 3T3 cells. , 1985, The Journal of biological chemistry.

[100]  O. Rosen,et al.  Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[101]  Jonathan A. Cooper,et al.  Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins , 1982, Cell.

[102]  M. Siegmann,et al.  Multiple phosphorylation of ribosomal protein S6 during transition of quiescent 3T3 cells into early G1, and cellular compartmentalization of the phosphate donor. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[103]  I. Wool,et al.  Effect of experimental diabetes and insulin on phosphorylation of rat liver ribosomal protein S6 , 1976, Nature.

[104]  I. Wool,et al.  The phosphorylation of liver ribosomal proteins in vivo. Evidence that only a single small subunit protein (S6) is phosphorylated. , 1974, The Journal of biological chemistry.