Immune attack: the role of inflammation in Alzheimer disease

[1]  R. Ransohoff,et al.  TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models , 2015, The Journal of experimental medicine.

[2]  K. Schroder,et al.  A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases , 2015, Nature Medicine.

[3]  D. Holtzman,et al.  TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model , 2015, Cell.

[4]  Nathan D. Price,et al.  IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior , 2015, Neuron.

[5]  S. Goerdt,et al.  Macrophage activation and polarization: nomenclature and experimental guidelines. , 2014, Immunity.

[6]  S. Beggs,et al.  Sublime Microglia: Expanding Roles for the Guardians of the CNS , 2014, Cell.

[7]  J. Molinuevo,et al.  TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis , 2014, Science Translational Medicine.

[8]  Michael T. Heneka,et al.  Innate immune activation in neurodegenerative disease , 2014, Nature Reviews Immunology.

[9]  A. Lo,et al.  Parallel Discovery of Alzheimer’s Therapeutics , 2014, Science Translational Medicine.

[10]  L. Tan,et al.  Interleukin-23 receptor polymorphisms are associated with Alzheimer's disease in Han Chinese , 2014, Journal of Neuroimmunology.

[11]  D. Holtzman,et al.  Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2 , 2014, Molecular Neurodegeneration.

[12]  Danielle A. Simmons,et al.  Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice , 2014, Nature Medicine.

[13]  Daphne Koller,et al.  Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes , 2014, Science.

[14]  Marco Prinz,et al.  Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease , 2014, Nature Reviews Neuroscience.

[15]  Shaomin Li,et al.  Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes , 2014, Neuron.

[16]  S. Hickman,et al.  TREM2 and the neuroimmunology of Alzheimer's disease. , 2014, Biochemical pharmacology.

[17]  V. Perry,et al.  Microglial priming in neurodegenerative disease , 2014, Nature Reviews Neurology.

[18]  D. Gomez-Nicola,et al.  Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease , 2014, Glia.

[19]  S. Gordon,et al.  The M1 and M2 paradigm of macrophage activation: time for reassessment , 2014, F1000prime reports.

[20]  M. Heneka,et al.  Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview , 2014, Molecular Neurobiology.

[21]  Tom C. Freeman,et al.  Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation , 2014, Immunity.

[22]  M. Sofroniew,et al.  Reactive Gliosis and the Multicellular Response to CNS Damage and Disease , 2014, Neuron.

[23]  A. Beltramello,et al.  Mild Cognitive Impairment in Patients with Moderate to Severe Chronic Plaque Psoriasis , 2014, Dermatology.

[24]  E. Koo,et al.  Emerging therapeutics for Alzheimer's disease. , 2014, Annual review of pharmacology and toxicology.

[25]  L. Tan,et al.  IL12/23 p40 inhibition ameliorates Alzheimer's disease-associated neuropathology and spatial memory in SAMP8 mice. , 2013, Journal of Alzheimer's disease : JAD.

[26]  K. Fassbender,et al.  Molecular links between endothelial dysfunction and neurodegeneration in Alzheimer's disease. , 2014, Current Alzheimer research.

[27]  J. Yates,et al.  Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor , 2013, Cell.

[28]  Gabriel Gold,et al.  Alzheimer disease therapy—moving from amyloid-β to tau , 2013, Nature Reviews Neurology.

[29]  Toshiro K. Ohsumi,et al.  The Microglial Sensome Revealed by Direct RNA Sequencing , 2013, Nature Neuroscience.

[30]  F. Heppner,et al.  Microglia actions in Alzheimer’s disease , 2013, Acta Neuropathologica.

[31]  E. Masliah,et al.  Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease , 2013, Neuron.

[32]  M. Franceschi,et al.  CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study. , 2013, Current Alzheimer research.

[33]  R. Myers,et al.  A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. , 2013, Cell reports.

[34]  D. Selkoe.  SnapShot: Pathobiology of Alzheimer's Disease , 2013, Cell.

[35]  S. Josefowicz.  Regulators of chromatin state and transcription in CD4 T‐cell polarization , 2013, Immunology.

[36]  J. O’Shea,et al.  Transcription factors and CD4 T cells seeking identity: masters, minions, setters and spikers , 2013, Immunology.

[37]  Christine E. Becker,et al.  CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation , 2013, Nature Immunology.

[38]  Nathan D. Kingery,et al.  Scara1 deficiency impairs clearance of soluble Amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression , 2013, Nature Communications.

[39]  P. Bickford,et al.  Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy , 2013, Neurobiology of Aging.

[40]  Sean J. Miller,et al.  Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models” , 2013, Science.

[41]  Keith A. Johnson,et al.  CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology , 2013, Nature Neuroscience.

[42]  F. Heppner,et al.  Microglia as Dynamic and Essential Components of the Amyloid Hypothesis , 2013, Neuron.

[43]  Bradley T. Hyman,et al.  Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta , 2013, Neuron.

[44]  F. LaFerla,et al.  Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. , 2013, The American journal of pathology.

[45]  L. Tran,et al.  Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease , 2013, Cell.

[46]  F. Heppner,et al.  Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology , 2013, PloS one.

[47]  F. Schmitt,et al.  Neuroinflammatory phenotype in early Alzheimer's disease , 2013, Neurobiology of Aging.

[48]  M. Nalls,et al.  Effect of Complement CR1 on Brain Amyloid Burden During Aging and Its Modification by APOE Genotype , 2013, Biological Psychiatry.

[49]  Griffin Ws.  Neuroinflammatory cytokine signaling and Alzheimer's disease. , 2013 .

[50]  F. LaFerla,et al.  Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony , 2013, Experimental Neurology.

[51]  A. Singleton,et al.  TREM2 variants in Alzheimer's disease. , 2013, The New England journal of medicine.

[52]  A. Hofman,et al.  Variant of TREM2 associated with the risk of Alzheimer's disease. , 2013, The New England journal of medicine.

[53]  C. Cunningham.  Microglia and neurodegeneration: The role of systemic inflammation , 2013, Glia.

[54]  M. Heneka,et al.  NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice , 2012, Nature.

[55]  I. Knuesel,et al.  Deciphering the mechanism underlying late-onset Alzheimer disease , 2013, Nature Reviews Neurology.

[56]  L. Ferraro,et al.  Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice , 2013, BMC Neuroscience.

[57]  D. Choi,et al.  Anti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-butenal in Tg2576 Alzheimer’s disease mice model , 2013, Journal of Neuroinflammation.

[58]  York Winter,et al.  Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline , 2012, Nature Medicine.

[59]  Michael T. Heneka,et al.  PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice , 2012, The Journal of Neuroscience.

[60]  D. Bennett,et al.  The Complex PrPc-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease , 2012, The Journal of Neuroscience.

[61]  M. Murphy,et al.  Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease , 2012, The Journal of Neuroscience.

[62]  Frank M LaFerla,et al.  Animal models of Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.

[63]  John X. Morris,et al.  Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease , 2012 .

[64]  B. Zlokovic,et al.  Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.

[65]  Ole A. Andreassen,et al.  A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline , 2012, Nature.

[66]  J. Lucas,et al.  In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases , 2012, Neurobiology of Aging.

[67]  T. Golde,et al.  Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition , 2012, Molecular Neurodegeneration.

[68]  R. Ransohoff,et al.  Animal models of multiple sclerosis: the good, the bad and the bottom line , 2012, Nature Neuroscience.

[69]  C. Cotman,et al.  Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study , 2012, Journal of Neuroinflammation.

[70]  Urs Meyer,et al.  Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice , 2012, Journal of Neuroinflammation.

[71]  L. Mucke,et al.  Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. , 2012, Cold Spring Harbor perspectives in medicine.

[72]  B. Barres,et al.  The complement system: an unexpected role in synaptic pruning during development and disease. , 2012, Annual review of neuroscience.

[73]  J. Hamilton,et al.  Defining GM-CSF– and Macrophage-CSF–Dependent Macrophage Responses by In Vitro Models , 2012, The Journal of Immunology.

[74]  M. Leissring,et al.  Proteolytic degradation of amyloid β-protein. , 2012, Cold Spring Harbor perspectives in medicine.

[75]  Ben A. Barres,et al.  Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner , 2012, Neuron.

[76]  Nirmal Singh,et al.  Mast cells: an expanding pathophysiological role from allergy to other disorders , 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

[77]  C. Haass,et al.  Trafficking and proteolytic processing of APP. , 2012, Cold Spring Harbor perspectives in medicine.

[78]  Donald A. Wilson,et al.  ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models , 2012, Science.

[79]  J. McLaurin,et al.  Clearance of amyloid-β peptides by microglia and macrophages: the issue of what, when and where. , 2012, Future neurology.

[80]  M. Dietrich,et al.  Obesity is associated with hypothalamic injury in rodents and humans. , 2012, The Journal of clinical investigation.

[81]  T. Kiyota,et al.  AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice , 2011, Gene Therapy.

[82]  T. Wyss-Coray,et al.  Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. , 2012, Cold Spring Harbor perspectives in medicine.

[83]  S. Love,et al.  Endothelin-1 is elevated in Alzheimer's disease and upregulated by amyloid-β. , 2012, Journal of Alzheimer's disease : JAD.

[84]  H. Tanila,et al.  Multiple cellular and molecular mechanisms Are involved in human Aβ clearance by transplanted adult astrocytes , 2011, Glia.

[85]  G. Natoli,et al.  Transcriptional regulation of macrophage polarization: enabling diversity with identity , 2011, Nature Reviews Immunology.

[86]  J. O’Shea,et al.  Helper T-cell Differentiation and Plasticity: Insights from Epigenetics Introduction , 2022 .

[87]  R. Ransohoff,et al.  Heterogeneity of CNS myeloid cells and their roles in neurodegeneration , 2011, Nature Neuroscience.

[88]  M. Giustetto,et al.  Synaptic Pruning by Microglia Is Necessary for Normal Brain Development , 2011, Science.

[89]  M. O’Banion,et al.  Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice , 2011, Journal of Neuroinflammation.

[90]  A. Mildner,et al.  Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease , 2011, The Journal of Neuroscience.

[91]  Simon C. Potter,et al.  Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis , 2011, Nature.

[92]  R. Green,et al.  Extended results of the Alzheimer’s disease anti-inflammatory prevention trial , 2011, Alzheimer's & Dementia.

[93]  D. Holtzman,et al.  Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-α Expression for Microglial Aβ Phagocytosis , 2011, The Journal of Neuroscience.

[94]  D. G. Clark,et al.  Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease , 2011, Nature Genetics.

[95]  Nick C Fox,et al.  Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease , 2011, Nature Genetics.

[96]  P. Grammas,et al.  Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease , 2011, Journal of Neuroinflammation.

[97]  T. Golde,et al.  Robust Amyloid Clearance in a Mouse Model of Alzheimer's Disease Provides Novel Insights into the Mechanism of Amyloid-β Immunotherapy , 2011, The Journal of Neuroscience.

[98]  J. Nabekura,et al.  Functions of microglia in the central nervous system--beyond the immune response. , 2011, Neuron glia biology.

[99]  J. Kaye,et al.  The ageing systemic milieu negatively regulates neurogenesis and cognitive function , 2011 .

[100]  S. Zanotti-Cavazzoni.  Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis , 2011 .

[101]  A. Verkhratsky,et al.  Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission? , 2011, Molecular Neurodegeneration.

[102]  L. Hugonot-Diener,et al.  Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial , 2011, Alzheimer's Research & Therapy.

[103]  T. Golde,et al.  Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo , 2011, Molecular Neurodegeneration.

[104]  J. Morris,et al.  Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease , 2010, Science.

[105]  N. Herrmann,et al.  A Meta-Analysis of Cytokines in Alzheimer's Disease , 2010, Biological Psychiatry.

[106]  R. Ransohoff,et al.  CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. , 2010, The American journal of pathology.

[107]  A. Troxel,et al.  Cause‐specific mortality in patients with severe psoriasis: a population‐based cohort study in the U.K. , 2010, The British journal of dermatology.

[108]  V. Perry.  Contribution of systemic inflammation to chronic neurodegeneration , 2010, Acta Neuropathologica.

[109]  M. Schwartz,et al.  Systemic inflammatory cells fight off neurodegenerative disease , 2010, Nature Reviews Neurology.

[110]  G. Landreth,et al.  The role of microglia in amyloid clearance from the AD brain , 2010, Journal of Neural Transmission.

[111]  A. Verkhratsky,et al.  Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease , 2010, Glia.

[112]  M. Citron.  Alzheimer's disease: strategies for disease modification , 2010, Nature Reviews Drug Discovery.

[113]  Richard M. Page,et al.  Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease , 2010, Nature Neuroscience.

[114]  V. Perry,et al.  Microglia in neurodegenerative disease , 2010, Nature Reviews Neurology.

[115]  Ryuichi Morishita,et al.  Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes , 2010, Proceedings of the National Academy of Sciences.

[116]  G. Halliday,et al.  Focal demyelination in Alzheimer’s disease and transgenic mouse models , 2010, Acta Neuropathologica.

[117]  D. Dickson,et al.  Massive gliosis induced by interleukin‐6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[118]  K. Moore,et al.  CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer , 2009, Nature Immunology.

[119]  Rena Li,et al.  Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients. , 2010, Journal of Alzheimer's disease : JAD.

[120]  F. LaFerla,et al.  Alzheimer's disease. , 2010, The New England journal of medicine.

[121]  M. Sofroniew,et al.  Astrocytes: biology and pathology , 2009, Acta Neuropathologica.

[122]  F. Heppner,et al.  Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia , 2009, Nature Neuroscience.

[123]  L. Kiemeney,et al.  Corrigendum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer , 2009, Nature Genetics.

[124]  G. Landreth,et al.  CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation , 2009, The Journal of Neuroscience.

[125]  V. Perry,et al.  Systemic inflammation and disease progression in Alzheimer disease , 2009, Neurology.

[126]  Nick C Fox,et al.  Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes , 2009, Nature Genetics.

[127]  P. Bosco,et al.  Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease , 2009, Nature Genetics.

[128]  J. McLaurin,et al.  Selective targeting of perivascular macrophages for β-amyloid clearance in cerebral amyloid angiopathy , 2009, Alzheimer's & Dementia.

[129]  C. Archer,et al.  An immunofluorescence method for postembedded tissue in the acrylic resin Technovit 9100 New® using fluorescein isothiocyanate secondary detection , 2009, Microscopy research and technique.

[130]  A. Michelucci,et al.  Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β , 2009, Journal of Neuroimmunology.

[131]  W. Seaman,et al.  A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia , 2009, Journal of neurochemistry.

[132]  L. Lue,et al.  Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway , 2009, Neurobiology of Disease.

[133]  M. Pizzi,et al.  CHF5074, a novel γ‐secretase modulator, attenuates brain β‐amyloid pathology and learning deficit in a mouse model of Alzheimer's disease , 2009, British journal of pharmacology.

[134]  T. Golde,et al.  Quantitative and Mechanistic Studies of Aβ Immunotherapy , 2009 .

[135]  V. Perry,et al.  Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease , 2009, Biological Psychiatry.

[136]  L. Lue,et al.  Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammation , 2009, Experimental Neurology.

[137]  D. Holtzman,et al.  Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-Aβ Antibody Administration in PDAPP Mice , 2008, The Journal of Neuroscience.

[138]  J. Ryu,et al.  Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimer's disease , 2008, Neuroreport.

[139]  I. Bechmann,et al.  TREM2 is upregulated in amyloid plaque‐associated microglia in aged APP23 transgenic mice , 2008, Glia.

[140]  S. Hickman,et al.  Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice , 2008, The Journal of Neuroscience.

[141]  Seth Love,et al.  Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial , 2008, The Lancet.

[142]  K. Moore,et al.  The NALP3 inflammasome is involved in the innate immune response to amyloid-β , 2008, Nature Immunology.

[143]  R. Green,et al.  Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. , 2008, Archives of neurology.

[144]  C. Lemere,et al.  Complement C3 Deficiency Leads to Accelerated Amyloid β Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice , 2008, The Journal of Neuroscience.

[145]  Jun Tan,et al.  Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology , 2008, Nature Medicine.

[146]  Hong-Duck Kim,et al.  Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease , 2008, Journal of Neuroinflammation.

[147]  Hyman Gross,et al.  Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration , 2007, Journal of Neuroinflammation.

[148]  Gregory A. Hickey,et al.  A limited role for microglia in antibody mediated plaque clearance in APP mice , 2007, Neurobiology of Disease.

[149]  M. Lotze,et al.  Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. , 2007, Trends in immunology.

[150]  R. Guerreiro,et al.  Peripheral Inflammatory Cytokines as Biomarkers in Alzheimer’s Disease and Mild Cognitive Impairment , 2007, Neurodegenerative Diseases.

[151]  W. Streit,et al.  The effects of aging, injury and disease on microglial function: a case for cellular senescence. , 2007, Neuron glia biology.

[152]  R. Green,et al.  Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial , 2007, Neurology.

[153]  C. Geula,et al.  Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease , 2007, Nature Medicine.

[154]  D. Selkoe,et al.  Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide , 2007, Nature Reviews Molecular Cell Biology.

[155]  Tony Wyss-Coray,et al.  Inflammation in Alzheimer disease: driving force, bystander or beneficial response? , 2006, Nature Medicine.

[156]  J. Julien,et al.  Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease , 2006, Neuron.

[157]  Mathias Hoehn,et al.  Locus Ceruleus Degeneration Promotes Alzheimer Pathogenesis in Amyloid Precursor Protein 23 Transgenic Mice , 2006, The Journal of Neuroscience.

[158]  A. Stalder,et al.  Invasion of Hematopoietic Cells into the Brain of Amyloid Precursor Protein Transgenic Mice , 2005, The Journal of Neuroscience.

[159]  K. Moore,et al.  Journal of Neuroinflammation BioMed Central , 2004 .

[160]  J. Wiltfang,et al.  Amyloid beta peptide 1–40 enhances the action of Toll‐like receptor‐2 and ‐4 agonists but antagonizes Toll‐like receptor‐9‐induced inflammation in primary mouse microglial cell cultures , 2005, Journal of neurochemistry.

[161]  V. Mathura,et al.  Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease , 2005, Journal of Neuroinflammation.

[162]  J. Dayer,et al.  Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3‐kinase‐mediated intracellular signaling , 2005, European journal of immunology.

[163]  R. von Bernhardi,et al.  Oligodendrocytes damage in Alzheimer's disease: beta amyloid toxicity and inflammation. , 2005, Biological research.

[164]  G. Landreth,et al.  Microglial Phagocytosis of Fibrillar β-Amyloid through a β1 Integrin-Dependent Mechanism , 2004, The Journal of Neuroscience.

[165]  Jun Zhou,et al.  Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease , 2004, The Journal of Neuroscience.

[166]  D. Wilcock,et al.  Passive Amyloid Immunotherapy Clears Amyloid and Transiently Activates Microglia in a Transgenic Mouse Model of Amyloid Deposition , 2004, The Journal of Neuroscience.

[167]  W. Streit,et al.  Microglia and Alzheimer's disease pathogenesis , 2004, Journal of neuroscience research.

[168]  S. Paul,et al.  Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides , 2004, Nature Medicine.

[169]  B. Penke,et al.  Amyloid β‐peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease , 2004 .

[170]  Dai Zhang,et al.  Tumor Necrosis Factor Death Receptor Signaling Cascade Is Required for Amyloid-β Protein-Induced Neuron Death , 2004, The Journal of Neuroscience.

[171]  D. Wilcock,et al.  Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration , 2004, Neurobiology of Disease.

[172]  D. Sparks,et al.  Dystrophic microglia in the aging human brain , 2004, Glia.

[173]  K. Ishii,et al.  The LPS receptor (CD14) links innate immunity with Alzheimer's disease , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[174]  K. Blennow,et al.  Intrathecal inflammation precedes development of Alzheimer’s disease , 2003, Journal of neurology, neurosurgery, and psychiatry.

[175]  K. Moore,et al.  CD36 Mediates the Innate Host Response to β-Amyloid , 2003, The Journal of experimental medicine.

[176]  K. Davis,et al.  Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. , 2003, JAMA.

[177]  P. Mcgeer,et al.  Expression of complement messenger RNAs and proteins by human oligodendroglial cells , 2003, Glia.

[178]  M. D'Andrea,et al.  Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains , 2003, Brain Research.

[179]  Dave Morgan,et al.  Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation , 2003, The Journal of Neuroscience.

[180]  Douglas R. McDonald,et al.  A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation , 2003, The Journal of Neuroscience.

[181]  T. Wyss-Coray,et al.  Adult mouse astrocytes degrade amyloid-β in vitro and in situ , 2003, Nature Network Boston.

[182]  R. Flavell,et al.  Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice , 2002, Nature Neuroscience.

[183]  R. Veerhuis,et al.  Neuroinflammation in Alzheimer's disease and prion disease , 2002, Glia.

[184]  P. Aisen.  The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease , 2002, The Lancet Neurology.

[185]  P. Proost,et al.  Up-Regulation of FPR2, a Chemotactic Receptor for Amyloid β 1–42 (Aβ42), in Murine Microglial Cells by TNFα , 2002, Neurobiology of Disease.

[186]  J. Hardy,et al.  The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .

[187]  John D Lambris,et al.  Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[188]  J. Breitner,et al.  Do nonsteroidal antiinflammatory drugs reduce the risk of Alzheimer's disease? , 2001, The New England journal of medicine.

[189]  L. Mucke,et al.  TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice , 2001, Nature Medicine.

[190]  T. Tedder,et al.  Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. , 2001, Genomics.

[191]  B. Sommer,et al.  Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice. , 2001, The American journal of pathology.

[192]  Rena Li,et al.  Deficiency of Complement Defense Protein CD59 May Contribute to Neurodegeneration in Alzheimer's Disease , 2000, The Journal of Neuroscience.

[193]  R. Motter,et al.  Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease , 2000, Nature Medicine.

[194]  Kristi Kincaid,et al.  M-1/M-2 Macrophages and the Th1/Th2 Paradigm1 , 2000, The Journal of Immunology.

[195]  C. Plata-salamán,et al.  Inflammation and Alzheimer’s disease , 2000, Neurobiology of Aging.

[196]  M. Mattson,et al.  Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. , 1999, Science.

[197]  F. Jessen,et al.  A genetic variation of the inflammatory cytokine interleukin‐6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease , 1999, Annals of neurology.

[198]  W. Streit,et al.  Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[199]  B. Chromy,et al.  Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release , 1998, Brain Research.

[200]  W. Tourtellotte,et al.  Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[201]  F. Maxfield,et al.  Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor , 1996, Neuron.

[202]  J. Loike,et al.  Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils , 1996, Nature.

[203]  G. Schellenberg,et al.  Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease , 1996, Nature Medicine.

[204]  Yaakov Stern,et al.  Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community‐dwelling elderly persons and their first‐degree relatives , 1993, Annals of neurology.

[205]  C. Cotman,et al.  Transforming growth factor-β1 is in plaques in Alzheimer and Down pathologies , 1993 .

[206]  S Gordon,et al.  Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation , 1992, The Journal of experimental medicine.

[207]  L. Buée,et al.  Elevated circulating tumor necrosis factor levels in Alzheimer's disease , 1991, Neuroscience Letters.

[208]  P. Mcgeer,et al.  Complement-activated oligodendroglia: A new pathogenic entity identified by immunostaining with antibodies to human complement proteins C3d and C4d , 1990, Neuroscience Letters.

[209]  W. Griffin,et al.  Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[210]  W. Hickey,et al.  Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. , 1988, Science.

[211]  R. Coffman,et al.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. , 1986, Journal of immunology.

[212]  C. Nathan,et al.  Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity , 1983, The Journal of experimental medicine.

[213]  G. Mackaness.  CELLULAR RESISTANCE TO INFECTION , 1962, The Journal of experimental medicine.

[214]  A. Lbert,et al.  Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease , 2022 .