Observations concerning the cholate; cholesterol relationship in clinical and experimental nephrosis.

The occurrence of hypercholesteremia in the nephrotic state is a long recognized phenomenon (1), but its mechanism remains to be determined. Apparently the hypercholesteremia cannot be ascribed to a primary "lipoid degeneration" of the kidney (2). Recently, studies from this laboratory (3-6) have indicated that there is a marked derangement of cholate metabolism in certain clinical and experimental states of hypercholesteremia. It therefore was considered of interest to investigate the metabolism of this particular steroid in both clinical and experimental nephrosis.

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[11]  W. R. Bloor.  THE BLOOD LIPOIDS IN NEPHRITIS , 1917 .