Metal ion binding by proteins: Current Opinion in Structural Biology 1992, 2:57…-60

Abstract The structural importance of metal ion binding to proteins has recently been studied using site-specific mutagenesis and synthetic peptide techniques. Metal binding to synthetic peptides with sequences corresponding to helix-loop-helix calcium-binding sites and ‘zinc fingers’ induces unstructured peptides to fold into structures similar to domains observed in native proteins.

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