Point-of-care testing in the overcrowded emergency department – can it make a difference?

Emergency departments (EDs) face several challenges in maintaining consistent quality care in the face of steadily increasing public demand. Improvements in the survival rate of critically ill patients in the ED are directly related to the advancement of early recognition and treatment. Frequent episodes of overcrowding and prolonged waiting times force EDs to operate beyond their capacity and threaten to impact upon patient care. The objectives of this review are as follows: (a) to establish overcrowding as a threat to patient outcomes, person-centered care, and public safety in the ED; (b) to describe scenarios in which point-of-care testing (POCT) has been found to ameliorate factors thought to contribute to overcrowding; and (c) to discuss how POCT can be used directly, and indirectly, to expedite patient care and improve outcomes. Various studies have shown that overcrowding in the ED has profound effects on operational efficiency and patient care. Several reports have quantified overcrowding in the ED and have described a relationship between heightened periods of overcrowding and delays in treatment, increased incidence of adverse events, and an even greater probability of mortality. In certain scenarios, POCT has been found to increase the number of patients discharged in a timely manner, expedite triage of urgent but non-emergency patients, and decrease delays to treatment initiation. This review concludes that POCT, when used effectively, may alleviate the negative impacts of overcrowding on the safety, effectiveness, and person-centeredness of care in the ED.

[1]  Paolo Prandoni,et al.  Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. , 2012, Chest.

[2]  S. Dovey,et al.  Changes in clinical practice and patient disposition following the introduction of point-of-care testing in a rural hospital. , 2010, Health policy.

[3]  K. Lewandrowski,et al.  Implementation of a rapid whole blood D-dimer test in the emergency department of an urban academic medical center: impact on ED length of stay and ancillary test utilization. , 2009, American journal of clinical pathology.

[4]  John Concato,et al.  Care in the emergency department: how crowded is overcrowded? , 2004, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[5]  Jennifer A. Lyon,et al.  A Systematic Review of Emergency Department Point-of-Care Cardiac Markers and Efficiency Measures , 2009 .

[6]  W. Guerra,et al.  Early detection and treatment of patients with severe sepsis by prehospital personnel. , 2013, The Journal of emergency medicine.

[7]  Jesse M Pines,et al.  Emergency department crowding is associated with poor care for patients with severe pain. , 2008, Annals of emergency medicine.

[8]  Gordon H Guyatt,et al.  Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. , 2012, Chest.

[9]  F. Apple,et al.  Decreased patient charges following implementation of point-of-care cardiac troponin monitoring in acute coronary syndrome patients in a community hospital cardiology unit. , 2006, Clinica chimica acta; international journal of clinical chemistry.

[10]  K J M Janssen,et al.  Excluding venous thromboembolism using point of care D-dimer tests in outpatients: a diagnostic meta-analysis , 2009, BMJ : British Medical Journal.

[11]  D. Mccrory,et al.  Evidence-Based Clinical Practice Guidelines Medical Therapy For Pulmonary Arterial Hypertension : ACCP , 2004 .

[12]  M. Pfisterer,et al.  Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea. , 2004, New England Journal of Medicine.

[13]  J. Wiler,et al.  Optimizing emergency department front-end operations. , 2010, Annals of emergency medicine.

[14]  P. Collinson,et al.  Interhospital variation in the RATPAC Trial (Randomised Assessment of Treatment using Panel Assay of Cardiac markers) , 2011, Emergency Medicine Journal.

[15]  A. Hall,et al.  The RATPAC (Randomised Assessment of Treatment using Panel Assay of Cardiac markers) trial: a randomised controlled trial of point-of-care cardiac markers in the emergency department. , 2011, Health technology assessment.

[16]  A. Kastrati,et al.  Evaluation of prolonged antithrombotic pretreatment ("cooling-off" strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial. , 2003, JAMA.

[17]  D. Gaieski,et al.  The utility of early lactate testing in undifferentiated pediatric systemic inflammatory response syndrome. , 2012, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[18]  R. Mellanby,et al.  Cardiac troponin I: evaluation I of a biomarker for the diagnosis of heart disease in the dog. , 2005, The Journal of small animal practice.

[19]  A. Jaffe,et al.  National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine practice guidelines: Analytical issues for biomarkers of heart failure. , 2008, Circulation.

[20]  Blood sample tube transporting system versus point of care technology in an emergency department; effect on time from collection to reporting? A randomised trial , 2012, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.

[21]  Zhen Yang,et al.  Cardiac markers and their point-of-care testing for diagnosis of acute myocardial infarction. , 2006, Clinical biochemistry.

[22]  Fergus Laughridge,et al.  The future of emergency care in the United States health system. , 2006, Annals of emergency medicine.

[23]  Erik Buskens,et al.  A Simulation-based Approach for Improving Utilization of Thrombolysis in Acute Brain Infarction , 2013, Medical care.

[24]  M. Endres,et al.  Prehospital thrombolysis in acute stroke , 2013, Neurology.

[25]  C. Reid,et al.  2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: the ADAPT trial. , 2012, Journal of the American College of Cardiology.

[26]  A. Likourezos,et al.  Substituting whole blood for urine in a bedside pregnancy test. , 2012, The Journal of emergency medicine.

[27]  K. Sin,et al.  Evidence-based point-of-care diagnostics: current status and emerging technologies. , 2013, Annual review of analytical chemistry.

[28]  Yang Liu,et al.  Point‐of‐care laboratory halves door‐to‐therapy‐decision time in acute stroke , 2011, Annals of neurology.

[29]  R. Califf,et al.  Time to Coronary Angiography and Outcomes Among Patients With High-Risk Non–ST-Segment–Elevation Acute Coronary Syndromes: Results From the SYNERGY Trial , 2007, Circulation.

[30]  Patrick Maison,et al.  Impact of point-of-care testing in the emergency department evaluation and treatment of patients with suspected acute coronary syndromes. , 2008, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[31]  J. Griffith,et al.  Clinical Features of Emergency Department Patients Presenting with Symptoms Suggestive of Acute Cardiac Ischemia: A Multicenter Study , 1998, Journal of Thrombosis and Thrombolysis.

[32]  Karel G M Moons,et al.  Safe exclusion of pulmonary embolism using the Wells rule and qualitative D-dimer testing in primary care: prospective cohort study , 2012, BMJ : British Medical Journal.

[33]  J. Bakker,et al.  Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. , 2010, American journal of respiratory and critical care medicine.

[34]  Mike Bradburn,et al.  The Randomised Assessment of Treatment using Panel Assay of Cardiac Markers (RATPAC) trial: a randomised controlled trial of point-of-care cardiac markers in the emergency department , 2010, Heart.

[35]  Shuhana Perveen,et al.  Point of Care D-Dimer Testing in the Emergency Department: A Bioequivalence Study , 2012, Annals of laboratory medicine.

[36]  C. Lindsell,et al.  A Time-and-Motion Study of the Processes Required to Obtain Cardiac Biomarker Assays Using Central Laboratory, Near-Patient Testing, and Bedside Point-of-Care Testing , 2012 .

[37]  D. Schriger,et al.  Annals of Emergency Medicine Journal Club. Emergency department crowding is associated with poor care for patients with severe pain. , 2008, Annals of Emergency Medicine.

[38]  E. Ivers,et al.  Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock , 2001 .

[39]  S. Daeschner Pulmonary embolism. , 1988, Nursing.

[40]  G. Jelinek,et al.  The association between hospital overcrowding and mortality among patients admitted via Western Australian emergency departments , 2006, The Medical journal of Australia.

[41]  Larry A Nathanson,et al.  Serum lactate as a predictor of mortality in emergency department patients with infection. , 2005, Annals of emergency medicine.

[42]  D. Aronsky,et al.  Decreasing lab turnaround time improves emergency department throughput and decreases emergency medical services diversion: a simulation model. , 2008, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[43]  N. Rathlev,et al.  Emergency Department overcrowding and ambulance diversion: the impact and potential solutions of extended boarding of admitted patients in the Emergency Department. , 2006, The Journal of emergency medicine.

[44]  K. Shah,et al.  Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock , 2010, Journal of Inflammation.

[45]  A. Jaffe,et al.  National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biomarkers of heart failure. , 2007, Clinical biochemistry.

[46]  Jack H. Ladenson,et al.  Cardiac Troponin I A Marker With High Specificity for Cardiac Injury , 1993, Circulation.

[47]  Gregory W Albers,et al.  Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials , 2010, The Lancet.

[48]  C. Sprung,et al.  Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock 2012 , 2013, Critical care medicine.

[49]  J. Pines,et al.  Point-of-care testing at triage decreases time to lactate level in septic patients. , 2010, The Journal of emergency medicine.

[50]  W. Gibler,et al.  Emergency department multimarker point-of-care testing reduces time to cardiac marker results without loss of diagnostic accuracy , 2006 .

[51]  Anisha Dharshi,et al.  The future of emergency care in the United States health system: a report from the Institute of Medicine. , 2006, Journal of pediatric surgery.

[52]  A. Singer,et al.  Point-of-care testing reduces length of stay in emergency department chest pain patients. , 2005, Annals of emergency medicine.

[53]  Astrid Guttmann,et al.  Association between waiting times and short term mortality and hospital admission after departure from emergency department: population based cohort study from Ontario, Canada , 2011, BMJ : British Medical Journal.