Neural correlates of the ‘good life’: eudaimonic well-being is associated with insular cortex volume

Eudaimonic well-being reflects traits concerned with personal growth, self-acceptance, purpose in life and autonomy (among others) and is a substantial predictor of life events, including health. Although interest in the aetiology of eudaimonic well-being has blossomed in recent years, little is known of the underlying neural substrates of this construct. To address this gap in our knowledge, here we examined whether regional gray matter (GM) volume was associated with eudaimonic well-being. Structural magnetic resonance images from 70 young, healthy adults who also completed Ryff’s 42-item measure of the six core facets of eudaimonia, were analysed with voxel-based morphometry techniques. We found that eudaimonic well-being was positively associated with right insular cortex GM volume. This association was also reflected in three of the sub-scales of eudaimonia: personal growth, positive relations and purpose in life. Positive relations also showed a significant association with left insula volume. No other significant associations were observed, although personal growth was marginally associated with left insula, and purpose in life exhibited a marginally significant negative association with middle temporal gyrus GM volume. These findings are the first to our knowledge linking eudaimonic well-being with regional brain structure.

[1]  Geraint Rees,et al.  Moral Values Are Associated with Individual Differences in Regional Brain Volume , 2012, Journal of Cognitive Neuroscience.

[2]  Woogul Lee,et al.  Self-determined, but not non-self-determined, motivation predicts activations in the anterior insular cortex: an fMRI study of personal agency. , 2013, Social cognitive and affective neuroscience.

[3]  A. Waterman.  Two conceptions of happiness: Contrasts of personal expressiveness (eudaimonia) and hedonic enjoyment. , 1993 .

[4]  Timothy C. Bates,et al.  Genetic influences on psychological well-being: a nationally representative twin study. , 2013, Journal of personality.

[5]  D. Schacter,et al.  The Brain's Default Network , 2008, Annals of the New York Academy of Sciences.

[6]  H. Critchley,et al.  A common role of insula in feelings, empathy and uncertainty , 2009, Trends in Cognitive Sciences.

[7]  J. Weizenbaum,et al.  Social science research. , 1970, Science.

[8]  V. Menon,et al.  Saliency, switching, attention and control: a network model of insula function , 2010, Brain Structure and Function.

[9]  C. Keyes,et al.  The structure of psychological well-being revisited. , 1995, Journal of personality and social psychology.

[10]  Matthew D. Lieberman,et al.  The Common Neural Basis of Exerting Self-Control in Multiple Domains , 2009 .

[11]  Yvette I. Sheline,et al.  Amygdala core nuclei volumes are decreased in recurrent major depression , 1998, Neuroreport.

[12]  Michael Marriott,et al.  Lower hippocampal volume in patients suffering from depression: a meta-analysis. , 2004, The American journal of psychiatry.

[13]  Thomas E. Nichols,et al.  Nonstationary cluster-size inference with random field and permutation methods , 2004, NeuroImage.

[14]  B. Singer,et al.  Best news yet on the six-factor model of well-being , 2006 .

[15]  M. Csíkszentmihályi,et al.  Positive psychology. An introduction. , 2000, The American psychologist.

[16]  R. Hauser,et al.  An assessment of the construct validity of Ryff’s Scales of Psychological Well-Being: Method, mode, and measurement effects , 2006 .

[17]  Eva Meisenzahl,et al.  Enlargement of the amygdala in patients with a first episode of major depression , 2002, Biological Psychiatry.

[18]  Jiing-Feng Lirng,et al.  Cortical and Subcortical Abnormalities in Late-Onset Depression With History of Suicide Attempts Investigated With MRI and Voxel-Based Morphometry , 2010, Journal of geriatric psychiatry and neurology.

[19]  E. Deci,et al.  On happiness and human potentials: a review of research on hedonic and eudaimonic well-being. , 2001, Annual review of psychology.

[20]  K. Berridge,et al.  Towards a functional neuroanatomy of pleasure and happiness , 2009, Trends in Cognitive Sciences.

[21]  M. Yücel,et al.  Amygdala and insula volumes prior to illness onset in bipolar disorder: A magnetic resonance imaging study , 2012, Psychiatry Research: Neuroimaging.

[22]  Britta K. Hölzel,et al.  Mindfulness practice leads to increases in regional brain gray matter density , 2011, Psychiatry Research: Neuroimaging.

[23]  J Mazziotta,et al.  A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM). , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[24]  M. Raichle,et al.  Searching for a baseline: Functional imaging and the resting human brain , 2001, Nature Reviews Neuroscience.

[25]  Kevin N. Ochsner,et al.  Self control in society, mind, and brain , 2010 .

[26]  A. Wood,et al.  The absence of positive psychological (eudemonic) well-being as a risk factor for depression: a ten year cohort study. , 2010, Journal of affective disorders.

[27]  E. Diener,et al.  Subjective well-being. , 1984, Psychological bulletin.

[28]  R. Kahn,et al.  Human brain changes across the life span: A review of 56 longitudinal magnetic resonance imaging studies , 2012, Human brain mapping.

[29]  C. Ryff.  Happiness is everything, or is it? Explorations on the meaning of psychological well-being. , 1989 .

[30]  B. Singer,et al.  Positive health: connecting well-being with biology. , 2004, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[31]  M. Milders,et al.  The insular cortex and the neuroanatomy of major depression. , 2011, Journal of affective disorders.

[32]  L Cipolotti,et al.  A volumetric study of hippocampus and amygdala in depressed patients with subjective memory problems. , 2000, The Journal of neuropsychiatry and clinical neurosciences.

[33]  Richard J. Davidson,et al.  Psychological Well-Being and Ill-Being: Do They Have Distinct or Mirrored Biological Correlates? , 2006, Psychotherapy and Psychosomatics.

[34]  C. Ryff.  Psychological Well-Being in Adult Life , 1995 .

[35]  Heather L. Urry,et al.  Making a Life Worth Living , 2004, Psychological science.

[36]  Aristotle,et al.  THE NICOMACHEAN ETHICS , 1990 .

[37]  A. Craig,et al.  How do you feel — now? The anterior insula and human awareness , 2009, Nature Reviews Neuroscience.

[38]  T. Kjaer,et al.  A 15O‐H2O PET study of meditation and the resting state of normal consciousness , 1999, Human brain mapping.

[39]  An assessment of the construct validity of the CCSEQ Quality of Effort scales , 1996 .

[40]  G. Rees,et al.  The structural basis of inter-individual differences in human behaviour and cognition , 2011, Nature Reviews Neuroscience.

[41]  Dieter Vaitl,et al.  Investigation of mindfulness meditation practitioners with voxel-based morphometry. , 2008, Social cognitive and affective neuroscience.