论文信息 - A computational model of the interaction of membrane potential oscillations with inhibitory synaptic input in cortical cells

A computational model of the interaction of membrane potential oscillations with inhibitory synaptic input in cortical cells

Abstract Oscillatory neuronal activity and inhibitory (GABAergic) synaptic input are believed to be important for cortical computation. We conducted a theoretical study to investigate the interaction between these processes. Depending on the phase of the oscillation they are evoked at, GABAergic synaptic potentials can either delay or prevent spikes. The reason is that most of the fast Na+-channels responsible for spike firing are deinactivated during the valley and rising phase as compared to the peak and falling phase of the oscillation.

[1] H. Markram,et al. Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. , 2000, Science.

[2] B. Sakmann,et al. A new cellular mechanism for coupling inputs arriving at different cortical layers , 1999, Nature.

[3] Nicholas T. Carnevale,et al. The NEURON Simulation Environment , 1997, Neural Computation.

[4] C. Gray,et al. Chattering Cells: Superficial Pyramidal Neurons Contributing to the Generation of Synchronous Oscillations in the Visual Cortex , 1996, Science.

[5] Wolf Singer,et al. Neuronal Synchrony: A Versatile Code for the Definition of Relations? , 1999, Neuron.

[6] Nicholas T. Carnevale,et al. Expanding NEURON's Repertoire of Mechanisms with NMODL , 2000, Neural Computation.

[7] T. Sejnowski,et al. A model of spike initiation in neocortical pyramidal neurons , 1995, Neuron.

[8] T. Sejnowski,et al. Reduced compartmental models of neocortical pyramidal cells , 1993, Journal of Neuroscience Methods.

[9] R. Traub,et al. On the Mechanism of the γ → β Frequency Shift in Neuronal Oscillations Induced in Rat Hippocampal Slices by Tetanic Stimulation , 1999, The Journal of Neuroscience.