Roep Reducing Proinsulin-Specific CD 8 + T Cells in Type 1 Diabetes Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically

diabetes. larger studies, a plasmid encoding proinsulin could serve as a targeted means of immunosuppression for type 1 T cells. If these data hold true in + T cells. No difference was observed in cytokine production by CD4 + unrelated CD8 T cells, but not + immune responses in these patients and found that there was a decrease in proinsulin-specific CD8 cell function. The authors then examined the β a readout of −− the experimental group had improved C-peptide levels proinsulin-expressing engineered plasmid or PBS vehicle. They observed no serious adverse events. The subjects in The authors randomized patients recently diagnosed with type 1 diabetes to receive various doses of either a patients. cell function in type 1 diabetes β demonstrate that an engineered plasmid that expresses proinsulin can preserve et al. target the specific autoreactive cells without suppressing the rest of the immune response. Now, Roep of the pancreas. One way to block this response is through immunosuppression; however, it has proven difficult to Type 1 diabetes is an autoimmune disease where an inflammatory response destroys the insulin-producing cells Diabetes Trial Hits Its Mark