The IEEE 802.11 standard and enhanced amendments have defined fourteen transmission rates (1/2/5.5/6/9/11/12/18/22/24/33/36/48/54 Mbit/s) for mobile stations to transmit and receive data frames. With the characteristic of modulation schemes, a higher level modulation scheme requires a higher signal-to-noise ratio (SNR) and, consequently, the data rate is inversely proportional with the transmission distance. Using a higher level modulation scheme, a higher network throughput can be expected; however, the frame error probability will also become higher. Doubtlessly, it is an open issue of selecting a proper modulation scheme for a pair of mobile stations in a time-varying indoor environment. This paper proposes a safe multiple access-rates transmission (SMART) scheme for enhancing the reliability of data transmission in the IEEE 802.11 multi-rate infrastructure wireless networks. The SMART scheme provides reliable transmission by reserving a retransmission period, which immediately follows the transmitted frame and is estimated from a lower transmission rate, for each transmitted frame. If any error occurs on the transmitted frame, the sender will retransmit it right away by using a lower transmission rate to make sure of successful retransmission. Otherwise, the reserved period will be taken by the access point (AP), which often has the longest waiting queue and is the bottleneck in infrastructure wireless networks. The efficiency of the proposed SMART scheme is evaluated by simulation. Simulation results show that the derived performance of the SMART scheme is significantly better than standard under the real environment with asymmetric traffic load.