Nano-tailoring; stitching alterations on viral coats.

Growing interest in utilizing protein assemblies for nanomaterials applications has spawned efforts to customize these scaffolds. Viral capsids have been modified with new chemical functionalities, typically at lysine or cysteine residues. Two innovative studies describe approaches to introduce modifications at virion tyrosine residues [1, 2].

[1]  Angela M. Belcher,et al.  Viruses as vehicles for growth, organization and assembly of materials 1 1 The Golden Jubilee Issue , 2003 .

[2]  J. Trent,et al.  Ordered nanoparticle arrays formed on engineered chaperonin protein templates , 2002, Nature materials.

[3]  Qian Wang,et al.  Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition. , 2003, Journal of the American Chemical Society.

[4]  Trevor Douglas,et al.  Host–guest encapsulation of materials by assembled virus protein cages , 1998, Nature.

[5]  John E. Johnson,et al.  Natural supramolecular building blocks. Cysteine-added mutants of cowpea mosaic virus. , 2002, Chemistry & biology.

[6]  Trevor Douglas,et al.  The Small Heat Shock Protein Cage from Methanococcus jannaschii Is a Versatile Nanoscale Platform for Genetic and Chemical Modification , 2003 .

[7]  John E. Johnson,et al.  Hybrid virus-polymer materials. 1. Synthesis and properties of PEG-decorated cowpea mosaic virus. , 2003 .

[8]  C. Niemeyer.  REVIEW Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science , 2022 .

[9]  Jacob M Hooker,et al.  Interior surface modification of bacteriophage MS2. , 2004, Journal of the American Chemical Society.

[10]  Chad A. Mirkin,et al.  Nanopatterning the chemospecific immobilization of cowpea mosaic virus capsid , 2003 .

[11]  J. Reif,et al.  DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires , 2003, Science.

[12]  Q. Wang,et al.  Icosahedral Virus Particles as Polyvalent Carbohydrate Display Platforms , 2003, Chembiochem : a European journal of chemical biology.

[13]  M. Young,et al.  Chemical modification of a viral cage for multivalent presentation. , 2002, Chemical communications.

[14]  A James Link,et al.  Non-canonical amino acids in protein engineering. , 2003, Current opinion in biotechnology.

[15]  M. Finn,et al.  Crosslinking of and coupling to viral capsid proteins by tyrosine oxidation. , 2004, Chemistry & biology.

[16]  John E. Johnson,et al.  Natural supramolecular building blocks. Wild-type cowpea mosaic virus. , 2002, Chemistry & biology.

[17]  Trevor Douglas,et al.  VIRUS PARTICLES AS TEMPLATES FOR MATERIALS SYNTHESIS , 1999 .

[18]  John E. Johnson,et al.  Icosahedral virus particles as addressable nanoscale building blocks. , 2002, Angewandte Chemie.

[19]  George Georgiou,et al.  Virus-Based Toolkit for the Directed Synthesis of Magnetic and Semiconducting Nanowires , 2004, Science.