Characteristics of cadaveric renal allograft recipients developing chronic rejection.

As the early results of renal transplantation improve, chronic rejection is increasing in relative importance as a cause of graft loss. The aetiology of the condition is unknown. In order to identify possible predisposing factors, the characteristics of 22 patients with chronic rejection were compared with those of 50 patients with stable graft function 2 years or more after transplantation. Patients with chronic rejection had significantly more acute rejection episodes in the first 6 months after transplant (P less than 0.01), a higher incidence of acute rejection with vascular features (P less than 0.01), and longer ischaemic times (P less than 0.05) compared to patients with stable graft function. In a logistic regression analysis both frequency and severity of acute rejection episodes were significantly associated with the subsequent development of chronic rejection. Thus chronic rejection is associated with early injury to the transplanted kidney.

[1]  C Harasyko,et al.  Kidney transplantation. , 1989, The Nursing clinics of North America.

[2]  R. Blamey,et al.  The late results of renal transplantation and the importance of chronic rejection as a cause of graft loss. , 1989, Annals of the Royal College of Surgeons of England.

[3]  P. Rowe,et al.  Chronic renal allograft rejection and cyclosporine. , 1988, Transplantation Proceedings.

[4]  P. Vereerstraeten,et al.  LATE MORTALITY AND MORBIDITY FIVE TO EIGHTEEN YEARS AFTER KIDNEY TRANSPLANTATION , 1988, Transplantation.

[5]  D G Altman,et al.  Calculating confidence intervals for regression and correlation. , 1988, British medical journal.

[6]  A. Sheil.  Clinical organ transplantation. , 1987, Transplantation Proceedings.

[7]  R. Luke,et al.  CYCLOSPORIN IN THERAPEUTIC DOSES INCREASES RENAL ALLOGRAFT VASCULAR RESISTANCE , 1986, The Lancet.

[8]  J. Feehally,et al.  IS CHRONIC RENAL TRANSPLANT REJECTION A NON-IMMUNOLOGICAL PHENOMENON? , 1986, The Lancet.

[9]  S. Gore,et al.  Kidney transplants in the United Kingdom. , 1986, Clinical transplants.

[10]  J. Salaman.  Transplantation Immunology: Clinical and Experimental. , 1985 .

[11]  W. Sluiter,et al.  PROSPECTIVE RANDOMISED TRIAL OF EARLY DIETARY PROTEIN RESTRICTION IN CHRONIC RENAL FAILURE , 1984, The Lancet.

[12]  A. Matas,et al.  The Value of Needle Renal Allograft Biopsy I. A Retrospective Study of Biopsies Performed During Putative Rejection Episodes , 1983, Annals of surgery.

[13]  T. Strom,et al.  LATE MORTALITY AND MORBIDITY IN RECIPIENTS OF LONG‐TERM RENAL ALLOGRAFTS , 1982, Transplantation.

[14]  B. Brenner,et al.  Compensatory renal hemodynamic injury: a final common pathway of residual nephron destruction. , 1982, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[15]  C. Hill,et al.  Advantages of low dose steroid from the day after renal transplantation. , 1980, Transplantation.

[16]  D. Evans,et al.  Percutaneous needle biopsies of renal allografts: the relationship between morphological changes present in biopsies and subsequent allograft function , 1977, Histopathology.

[17]  M. R. Mickey,et al.  Calculations on long-term graft and patient survival in human kidney transplantation. , 1977, Transplantation Proceedings.

[18]  The 13th report of the human renal transplant registry. , 1977, Transplantation proceedings.

[19]  J. R. Batchelor.  Mechanisms of graft rejection. , 1969, Proceedings of the Royal Society of Medicine.

[20]  M. Polley.  Renal transplantation. , 1967, Nursing times.