The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.

[1]  Yinghua Zhu,et al.  Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras. , 2006, Human molecular genetics.

[2]  J. Hirsch,et al.  Cyclic AMP-Independent Regulation of Protein Kinase A Substrate Phosphorylation by Kelch Repeat Proteins , 2005, Eukaryotic Cell.

[3]  J. Heitman,et al.  Galpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae. , 2005, Molecular biology of the cell.

[4]  Enzo Martegani,et al.  Activation State of the Ras2 Protein and Glucose-induced Signaling in Saccharomyces cerevisiae* , 2004, Journal of Biological Chemistry.

[5]  J. Thevelein,et al.  Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae. , 2004, Molecular cell.

[6]  M. Jacquet,et al.  Tfs1p, a Member of the PEBP Family, Inhibits the Ira2p but Not the Ira1p Ras GTPase-Activating Protein in Saccharomyces cerevisiae , 2004, Eukaryotic Cell.

[7]  Cora Styles,et al.  Genetic and Epigenetic Regulation of the FLO Gene Family Generates Cell-Surface Variation in Yeast , 2004, Cell.

[8]  J. Heitman,et al.  6 Nutrient control of dimorphic growth in Saccharomyces cerevisiae , 2004 .

[9]  Anita Preininger,et al.  Insights into G protein structure, function, and regulation. , 2003, Endocrine reviews.

[10]  Steven P Gygi,et al.  A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[11]  D. Gutmann,et al.  The Neurofibromatosis 1 Gene Product Neurofibromin Regulates Pituitary Adenylate Cyclase-Activating Polypeptide-Mediated Signaling in Astrocytes , 2003, The Journal of Neuroscience.

[12]  X. Estivill,et al.  Recurrent mutations in the NF1 gene are common among neurofibromatosis type 1 patients , 2003, Journal of medical genetics.

[13]  T. Jacks,et al.  Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. , 2003, Genes & development.

[14]  J. Hirsch,et al.  Krh1p and Krh2p act downstream of the Gpa2p Gα subunit to negatively regulate haploid invasive growth , 2003, Journal of Cell Science.

[15]  Stefan Hohmann,et al.  Topics in current genetics , 2003 .

[16]  L. Parada,et al.  The Molecular and Genetic Basis of Neurological Tumours , 2002, Nature Reviews Cancer.

[17]  J. Heitman,et al.  The Gα Protein Gpa2 Controls Yeast Differentiation by Interacting with Kelch Repeat Proteins that Mimic Gβ Subunits , 2002 .

[18]  B. Dallapiccola,et al.  Ten novel mutations in the human neurofibromatosis type 1 (NF1) gene in Italian patients , 2002, Human mutation.

[19]  Yinghua Zhu,et al.  Neurofibromin regulates G protein–stimulated adenylyl cyclase activity , 2002, Nature Neuroscience.

[20]  G. Bollag,et al.  Neurofibromin GTPase-activating Protein-related Domains Restore Normal Growth in Nf1−/− Cells* , 2001, The Journal of Biological Chemistry.

[21]  J. Yates,et al.  Large-scale analysis of the yeast proteome by multidimensional protein identification technology , 2001, Nature Biotechnology.

[22]  P. Nürnberg,et al.  Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain. , 2000, American journal of human genetics.

[23]  Y. Zhong,et al.  A neurofibromatosis-1-regulated pathway is required for learning in Drosophila , 2000, Nature.

[24]  J. Heitman,et al.  The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. , 2000, Genetics.

[25]  E M Ross,et al.  GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. , 2000, Annual review of biochemistry.

[26]  A. Levitzki,et al.  The N-terminal half of Cdc25 is essential for processing glucose signaling in Saccharomyces cerevisiae. , 1999, Biochemistry.

[27]  H. Kumagai,et al.  Gpr1p, a putative G-protein coupled receptor, regulates glucose-dependent cellular cAMP level in yeast Saccharomyces cerevisiae. , 1998, Biochemical and biophysical research communications.

[28]  J. D. de Winde,et al.  Involvement of distinct G‐proteins, Gpa2 and Ras, in glucose‐ and intracellular acidification‐induced cAMP signalling in the yeast Saccharomyces cerevisiae , 1998, The EMBO journal.

[29]  J. Hirsch,et al.  GPR1 encodes a putative G protein‐coupled receptor that associates with the Gpa2p Gα subunit and functions in a Ras‐independent pathway , 1998, The EMBO journal.

[30]  J. Heitman,et al.  Yeast pseudohyphal growth is regulated by GPA2, a G protein α homolog , 1997 .

[31]  M. Lisanti,et al.  Gpa2p, a G-protein α-Subunit, Regulates Growth and Pseudohyphal Development in Saccharomyces cerevisiae via a cAMP-dependent Mechanism* , 1997, The Journal of Biological Chemistry.

[32]  J. Gusella,et al.  Rescue of a Drosophila NF1 mutant phenotype by protein kinase A. , 1997, Science.

[33]  Y. Zhong,et al.  Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides. , 1997, Science.

[34]  J. Broach,et al.  Ras membrane targeting is essential for glucose signaling but not for viability in yeast. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[35]  J. Field,et al.  Interactions between adenylyl cyclase, CAP and RAS from Saccharomyces cerevisiae. , 1994, Cellular signalling.

[36]  P. Fürst,et al.  The Saccharomyces cerevisiae CDC25 gene product binds specifically to catalytically inactive ras proteins in vivo , 1992, Molecular and cellular biology.

[37]  D. Lowy,et al.  Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis , 1992, Cell.

[38]  M. Boguski,et al.  cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. , 1991, Genomics.

[39]  W. Heideman,et al.  Interactions between adenylate cyclase and the yeast GTPase-activating protein IRA1 , 1991, Molecular and cellular biology.

[40]  F. Tamanoi,et al.  IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase-activating protein. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[41]  F. Sherman.  Getting started with yeast. , 1991, Methods in enzymology.

[42]  J. Thorner,et al.  Model systems for the study of seven-transmembrane-segment receptors. , 1991, Annual review of biochemistry.

[43]  Koji Kariya-city Aichi-pref. Tanaka.  IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase protein , 1991 .

[44]  M. Wigler,et al.  The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins , 1990, Cell.

[45]  F. Tamanoi,et al.  The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae , 1990, Cell.

[46]  P. O’Connell,et al.  The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21 , 1990, Cell.

[47]  N. Copeland,et al.  Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway , 1990, Nature.

[48]  Margaret Robertson,et al.  The neurofibromatosis type 1 gene encodes a protein related to GAP , 1990, Cell.

[49]  K. Matsumoto,et al.  IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein. , 1990, Molecular and cellular biology.

[50]  B. Brownstein,et al.  Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. , 1990, Science.

[51]  P. O'Connell,et al.  Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus , 1990, Cell.

[52]  P. O'Connell,et al.  A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations , 1990, Cell.

[53]  M. Jacquet,et al.  Enhancement of the GDP-GTP exchange of RAS proteins by the carboxyl-terminal domain of SCD25. , 1990, Science.

[54]  M. Nakafuku,et al.  S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein , 1990, Cell.

[55]  M. Wigler,et al.  Genetic analysis of mammalian GAP expressed in yeast , 1989, Cell.

[56]  K. Matsumoto,et al.  IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae , 1989, Molecular and cellular biology.

[57]  H. Küntzel,et al.  Glucose‐induced cAMP signaling in Saccharomyces cerevisiae is mediated by the CDC25 protein , 1989, FEBS letters.

[58]  M. Wigler,et al.  Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method , 1988, Molecular and cellular biology.

[59]  M. Wigler,et al.  SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. , 1988, Genes & development.

[60]  Michael Wigler,et al.  Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase , 1987, Cell.

[61]  M. Wigler,et al.  Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae , 1987, Molecular and cellular biology.

[62]  F. Portillo,et al.  The Saccharomyces cerevisiae start mutant carrying the cdc25 mutation is defective in activation of plasma membrane ATPase by glucose , 1986, Journal of bacteriology.

[63]  M. Wigler,et al.  Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins , 1984, Cell.