Hydroxyapatite mineral enhances malignant potential in a tissue-engineered model of ductal carcinoma in situ (DCIS).

[1]  J. Friedrichs,et al.  Intrafibrillar, bone-mimetic collagen mineralization regulates breast cancer cell adhesion and migration. , 2019, Biomaterials.

[2]  Aaron E. Chiou,et al.  Studying biomineralization pathways in a 3D culture model of breast cancer microcalcifications. , 2018, Biomaterials.

[3]  I. Barman,et al.  Mapping the genetic basis of breast microcalcifications and their role in metastasis , 2018, Scientific Reports.

[4]  N. Toschi,et al.  Radiological, Histological and Chemical Analysis of Breast Microcalcifications: Diagnostic Value and Biological Significance , 2018, Journal of Mammary Gland Biology and Neoplasia.

[5]  P. Granja,et al.  CD44v6 increases gastric cancer malignant phenotype by modulating adipose stromal cell-mediated ECM remodeling. , 2018, Integrative biology : quantitative biosciences from nano to macro.

[6]  Meredith M. Lee,et al.  Correlative imaging reveals physiochemical heterogeneity of microcalcifications in human breast carcinomas. , 2017, Journal of structural biology.

[7]  N. Toschi,et al.  Breast Osteoblast‐like Cells: A Reliable Early Marker for Bone Metastases From Breast Cancer , 2017, Clinical breast cancer.

[8]  Jonathan J. Chen,et al.  Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration , 2017, Nature Communications.

[9]  R. Weinberg,et al.  EMT, CSCs, and drug resistance: the mechanistic link and clinical implications , 2017, Nature Reviews Clinical Oncology.

[10]  D. Gourdon,et al.  Protein-crystal interface mediates cell adhesion and proangiogenic secretion. , 2017, Biomaterials.

[11]  C. Kendall,et al.  Relationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sections , 2016, npj Breast Cancer.

[12]  Aaron E. Chiou,et al.  Three-Dimensional Mechanical Loading Modulates the Osteogenic Response of Mesenchymal Stem Cells to Tumor-Derived Soluble Signals. , 2016, Tissue engineering. Part A.

[13]  Jeffrey T Leek,et al.  Evolution of cellular morpho-phenotypes in cancer metastasis , 2015, Scientific Reports.

[14]  L. Estroff,et al.  Chemical and physical properties of carbonated hydroxyapatite affect breast cancer cell behavior. , 2015, Acta biomaterialia.

[15]  Claudia Fischbach,et al.  3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways. , 2015, Biomaterials.

[16]  J. Morales-Montor,et al.  The role of cytokines in breast cancer development and progression. , 2015, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[17]  Claudia Fischbach,et al.  Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche. , 2013, Cancer research.

[18]  H. Lee,et al.  Epithelial-mesenchymal transition increases during the progression of in situ to invasive basal-like breast cancer. , 2013, Human pathology.

[19]  J. Milovanović,et al.  Interleukin-8 in breast cancer progression. , 2013, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[20]  J. Reis-Filho,et al.  Progression from ductal carcinoma in situ to invasive breast cancer: Revisited , 2013, Molecular oncology.

[21]  R. Clarke,et al.  Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells , 2013, Breast Cancer Research.

[22]  C. Fischbach,et al.  Engineered culture models for studies of tumor-microenvironment interactions. , 2013, Annual review of biomedical engineering.

[23]  Guangyu Liu,et al.  Malignant calcification is an important unfavorable prognostic factor in primary invasive breast cancer , 2013, Asia-Pacific journal of clinical oncology.

[24]  M. Morgan,et al.  Microcalcifications in breast cancer: Lessons from physiological mineralization. , 2013, Bone.

[25]  D. Cohen,et al.  Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines , 2013, International journal of breast cancer.

[26]  Bonnie F. Sloane,et al.  RNA-Seq of Human Breast Ductal Carcinoma In Situ Models Reveals Aldehyde Dehydrogenase Isoform 5A1 as a Novel Potential Target , 2012, PloS one.

[27]  V. Préat,et al.  RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis. , 2012, Molecular pharmaceutics.

[28]  Duane H. Hamilton,et al.  Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment. , 2012, Future oncology.

[29]  B. Teh,et al.  As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial–mesenchymal transition and activation of AKT signaling , 2012, Carcinogenesis.

[30]  M. Morgan,et al.  Microcalcifications in breast cancer: novel insights into the molecular mechanism and functional consequence of mammary mineralisation , 2012, British Journal of Cancer.

[31]  Chun-Yin Huang,et al.  IL‐8 increases integrin expression and cell motility in human chondrosarcoma cells , 2011, Journal of cellular biochemistry.

[32]  Marianne D. Castillo,et al.  IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. , 2011, Cancer research.

[33]  L. Estroff,et al.  Hydroxyapatite nanoparticle-containing scaffolds for the study of breast cancer bone metastasis. , 2011, Biomaterials.

[34]  Solveig Hofvind,et al.  Mammographic morphology and distribution of calcifications in ductal carcinoma in situ diagnosed in organized screening , 2011, Acta radiologica.

[35]  Sophia Hsin-Jung Li,et al.  Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast , 2011, Cell.

[36]  C. Fischbach,et al.  A Novel 3-D Mineralized Tumor Model to Study Breast Cancer Bone Metastasis , 2010, PloS one.

[37]  P. Friedl,et al.  The Journal of Cell Biology , 2002 .

[38]  H. Kuwano,et al.  Phosphoglucose Isomerase/Autocrine Motility Factor Promotes Melanoma Cell Migration through ERK Activation Dependent on Autocrine Production of Interleukin-8* , 2009, The Journal of Biological Chemistry.

[39]  Kinneret Keren,et al.  The Shape of Motile Cells , 2009, Current Biology.

[40]  M. Novotný,et al.  The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells , 2009, Cellular and Molecular Life Sciences.

[41]  Yaguang Xi,et al.  Spheroid-forming subpopulation of breast cancer cells demonstrates vasculogenic mimicry via hsa-miR-299–5p regulated de novo expression of osteopontin , 2009, Journal of cellular and molecular medicine.

[42]  Eugene A. Kapp,et al.  Secretome-based proteomic profiling of Ras-transformed MDCK cells reveals extracellular modulators of epithelial-mesenchymal transition. , 2009, Journal of proteome research.

[43]  R. Weinberg,et al.  Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits , 2009, Nature Reviews Cancer.

[44]  F. Bertucci,et al.  Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. , 2009, Cancer research.

[45]  David J Mooney,et al.  Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement , 2009, Proceedings of the National Academy of Sciences.

[46]  P. Tan,et al.  Intermediate to highly suspicious calcification in breast lesions: a radio-pathologic correlation , 2008, Breast Cancer Research and Treatment.

[47]  Thomas D. Schmittgen,et al.  Analyzing real-time PCR data by the comparative CT method , 2008, Nature Protocols.

[48]  Jun Yao,et al.  Regulation of in situ to invasive breast carcinoma transition. , 2008, Cancer cell.

[49]  E. McSherry,et al.  Molecular basis of invasion in breast cancer. , 2007, Cellular and molecular life sciences : CMLS.

[50]  Ying Lin,et al.  Interleukin‐8 modulates growth and invasiveness of estrogen receptor‐negative breast cancer cells , 2007, International journal of cancer.

[51]  H. Kuerer,et al.  Current treatment and clinical trial developments for ductal carcinoma in situ of the breast. , 2007, The oncologist.

[52]  E. McSherry,et al.  Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer , 2007, Cellular and Molecular Life Sciences.

[53]  Ross Tubo,et al.  Mesenchymal stem cells within tumour stroma promote breast cancer metastasis , 2007, Nature.

[54]  Tobias Schmelzle,et al.  Engineering tumors with 3D scaffolds , 2007, Nature Methods.

[55]  S. E. Jacobsen,et al.  Potential risks of bone marrow cell transplantation into infarcted hearts. , 2007, Blood.

[56]  Genee Y. Lee,et al.  The morphologies of breast cancer cell lines in three‐dimensional assays correlate with their profiles of gene expression , 2007, Molecular oncology.

[57]  C. Chi,et al.  Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cells. , 2007, Cancer research.

[58]  A. Lucci,et al.  Involvement of IL-8 in COX-2-mediated bone metastases from breast cancer. , 2006, The Journal of surgical research.

[59]  G. Christofori.  New signals from the invasive front , 2006, Nature.

[60]  Bircan Erbas,et al.  The natural history of ductal carcinoma in situ of the breast: a review , 2006, Breast Cancer Research and Treatment.

[61]  Byung-Soo Kim,et al.  Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering. , 2006, Biomaterials.

[62]  J. Thiery,et al.  Complex networks orchestrate epithelial–mesenchymal transitions , 2006, Nature Reviews Molecular Cell Biology.

[63]  E. van Marck,et al.  Increased Serum Interleukin-8 in Patients with Early and Metastatic Breast Cancer Correlates with Early Dissemination and Survival , 2004, Clinical Cancer Research.

[64]  D. Salter,et al.  Latent effects of fibronectin, α5β1 integrin, αVβ5 integrin and the cytoskeleton regulate pancreatic carcinoma cell IL-8 secretion , 2004, British Journal of Cancer.

[65]  Y. Yoon,et al.  Unexpected Severe Calcification After Transplantation of Bone Marrow Cells in Acute Myocardial Infarction , 2004, Circulation.

[66]  J. Theriot,et al.  Crawling toward a unified model of cell mobility: spatial and temporal regulation of actin dynamics. , 2004, Annual review of biochemistry.

[67]  Shiyong Li,et al.  Identification of interleukin‐8 as estrogen receptor‐regulated factor involved in breast cancer invasion and angiogenesis by protein arrays , 2004, International journal of cancer.

[68]  S. Morrison,et al.  Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[69]  A. Lucas,et al.  IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells , 2003, Oncogene.

[70]  David A. Cheresh,et al.  Get a ligand, get a life: integrins, signaling and cell survival , 2002, Journal of Cell Science.

[71]  R. Dasari,et al.  Identifying microcalcifications in benign and malignant breast lesions by probing differences in their chemical composition using Raman spectroscopy. , 2002, Cancer research.

[72]  J. Thiery.  Epithelial–mesenchymal transitions in tumour progression , 2002, Nature Reviews Cancer.

[73]  M. Morgan,et al.  Calcium hydroxyapatite promotes mitogenesis and matrix metalloproteinase expression in human breast cancer cell lines , 2001, Molecular carcinogenesis.

[74]  J W Smith,et al.  Integrin activation controls metastasis in human breast cancer. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[75]  J. Manivel,et al.  A potential role for interleukin-8 in the metastatic phenotype of breast carcinoma cells. , 2001, The American journal of pathology.

[76]  G. Hunter,et al.  Binding of Bone Sialoprotein, Osteopontin and Synthetic Polypeptides to Hydroxyapatite , 2001, Connective tissue research.

[77]  A. Green,et al.  Expression of cytokine messenger RNA in normal and neoplastic human breast tissue: Identification of interleukin‐8 as a potential regulatory factor in breast tumours , 1997, International journal of cancer.

[78]  A. Jemal,et al.  Cancer statistics, 2018 , 2018, CA: a cancer journal for clinicians.

[79]  L. Wilkinson,et al.  Microcalcification on mammography: approaches to interpretation and biopsy. , 2017, The British journal of radiology.

[80]  W. Murphy,et al.  Mineral particles modulate osteo-chondrogenic differentiation of embryonic stem cell aggregates. , 2016, Acta biomaterialia.

[81]  A. Minden,et al.  Differential Expression of Key Signaling Proteins in MCF10 Cell Lines, a Human Breast Cancer Progression Model. , 2012, Molecular and cellular pharmacology.

[82]  Virginia Espina,et al.  What is the malignant nature of human ductal carcinoma in situ? , 2011, Nature Reviews Cancer.

[83]  Jiawei He,et al.  Osteogenesis and trophic factor secretion are influenced by the composition of hydroxyapatite/poly(lactide-co-glycolide) composite scaffolds. , 2010, Tissue engineering. Part A.

[84]  S. Ahmed,et al.  Genetic variation in IL-8 associated with increased risk and poor prognosis of breast carcinoma. , 2006, Human immunology.

[85]  B. Dave,et al.  Autocrine Role of Interleukin-8 in Induction of Endothelial Cell Proliferation, Survival, Migration and MMP-2 Production and Angiogenesis , 2005, Angiogenesis.

[86]  Gerald F. Joyce,et al.  CRAWLING TOWARD A UNIFIED MODEL OF CELL MOTILITY : Spatial and Temporal Regulation of Actin Dynamics , 2005 .

[87]  P. Herrlich,et al.  CD44: From adhesion molecules to signalling regulators , 2003, Nature Reviews Molecular Cell Biology.

[88]  R. Ferrante,et al.  Prospective identification of tumorigenic breast cancer cells , 2003 .