SCEDOSPORIUM PROLIFICANS: AN UNCOMMON CAUSE OF SEPTIC ARTHRITIS

Septic arthritis due to fungal infection is uncommon, but when it does occur it can have a devastating effect. Scedosporium prolificans is an emerging fungal pathogen that appears to have a predilection for bone and cartilaginous surfaces. This fungus is resistant to most commonly prescribed antifungal agents. We report the successful treatment of Scedosporium prolificans septic arthritis with a combination of surgery and new antifungal agents.

[1]  R. Summerbell,et al.  Potted plants in hospitals as reservoirs of pathogenic fungi , 1989, Mycopathologia.

[2]  Peter Shaw,et al.  Scedosporium infection in immunocompromised patients: successful use of liposomal amphotericin B and itraconazole. , 2001, Medical and pediatric oncology.

[3]  J. Guarro,et al.  In Vitro Activities of Four Novel Triazoles againstScedosporium spp , 2001, Antimicrobial Agents and Chemotherapy.

[4]  E. Pérez-Trallero,et al.  Disseminated infection and colonization by Scedosporium prolificans: a review of 18 cases, 1990-1999. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[5]  J. Rodríguez-Tudela,et al.  Airborne outbreak of nosocomial Scedosporium prolificans infection , 2001, The Lancet.

[6]  J. Meis,et al.  Combination chemotherapy for the treatment of invasive infections by Scedosporium prolificans. , 2000, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[7]  R. Salomão,et al.  Production of IFN-gamma is impaired in patients with paracoccidioidomycosis during active disease and is restored after clinical remission. , 2000, Medical mycology.

[8]  D. Ellis,et al.  Clinical, pathologic and epidemiologic features of infection with Scedosporium prolificans: four cases and review , 1999 .

[9]  D. Muir,et al.  Experience with infection by Scedosporium prolificans including apparent cure with fluconazole therapy. , 1996, The Journal of infection.

[10]  J. V. D. van der Meer,et al.  [Emerging pathogens]. , 1996, Nederlands tijdschrift voor geneeskunde.

[11]  C. Cooper,et al.  Ribosomal DNA internal transcribed spacer analysis supports synonomy of Scedosporium inflatum and Lomentospora prolificans , 1994, Journal of clinical microbiology.

[12]  D. Muir,et al.  Clinical features of human infection with Scedosporium inflatum. , 1992, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[13]  M. Rinaldi,et al.  Endocarditis and hip arthritis associated with Scedosporium inflatum. , 1990, Southern medical journal.

[14]  M. Mcginnis,et al.  Scedosporium inflatum: clinical spectrum of a newly recognized pathogen. , 1990, The Journal of infectious diseases.

[15]  R. Dee.  Principles of Orthopaedic Practice , 1989 .

[16]  M. Rinaldi,et al.  Scedosporium inflatum, an emerging pathogen , 1988, Journal of clinical microbiology.

[17]  I. Salkin,et al.  A new species of Scedosporium associated with osteomyelitis in humans , 1984 .

[18]  E. Bruck,et al.  National Committee for Clinical Laboratory Standards. , 1980, Pediatrics.