Modelling haemoglobin incremental loss on chronic red blood cell transfusions

Understanding the impact of red blood cell (RBC) lifespan, initial RBC removal, and transfusion intervals on patient haemoglobin (Hb) levels and total iron exposure is not accessible for chronic transfusion scenarios. This article introduces the first model to help clinicians optimize chronic transfusion intervals to minimize transfusion frequency.

[1]  F. Pirenne,et al.  Red Blood Cell Transfusion in the Emergency Department: An Observational Cross-Sectional Multicenter Study , 2021, Journal of clinical medicine.

[2]  F. Fagnoni,et al.  Impact of the preparation method of red cell concentrates on transfusion indices in thalassemia patients: A randomized crossover clinical trial , 2021, Transfusion.

[3]  F. Vinchi,et al.  Controversies on the Consequences of Iron Overload and Chelation in MDS , 2020, HemaSphere.

[4]  Immunologic Concepts in Transfusion Medicine , 2020 .

[5]  G. Escobar,et al.  Effect of donor, component and recipient characteristics on hemoglobin increments following red blood cell transfusion. , 2019, Blood.

[6]  E. Murphy,et al.  The impact of recipient factors on the lower‐than‐expected hemoglobin increment in transfused outpatients with hematologic diseases , 2019, Transfusion.

[7]  E. Hellström-Lindberg,et al.  A longer duration of red blood cell storage is associated with a lower hemoglobin increase after blood transfusion: a cohort study , 2019, Transfusion.

[8]  E. Wood,et al.  Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference , 2019, JAMA.

[9]  T. Hervig,et al.  Cytokine profiling and post‐transfusion haemoglobin increment in patients with haematological diseases , 2018, Vox sanguinis.

[10]  C. Spies,et al.  Duration of storage influences the hemoglobin rising effect of red blood cells in patients undergoing major abdominal surgery , 2018, Transfusion.

[11]  D. Cooper,et al.  Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis. , 2018, Transfusion medicine reviews.

[12]  F. Meng,et al.  Human erythrocyte lifespan measured by Levitt’s CO breath test with newly developed automatic instrument , 2018, Journal of breath research.

[13]  S. Yedgar,et al.  Hemodynamic Functionality of Transfused Red Blood Cells in the Microcirculation of Blood Recipients , 2018, Front. Physiol..

[14]  S. Spitalnik,et al.  Transfusion-related immunomodulation: a reappraisal , 2017, Current opinion in hematology.

[15]  C. Morkane,et al.  Should modulation of p50 be a therapeutic target in the critically ill? , 2017, Expert review of hematology.

[16]  Donald J. McMahon,et al.  Prolonged red cell storage before transfusion increases extravascular hemolysis , 2017, The Journal of clinical investigation.

[17]  Richard J Cook,et al.  Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion. , 2016, The New England journal of medicine.

[18]  Dharmakanta Kumbhakar TRANSFUSION OF NEOCYTES CONCENTRATE/POOLED NEOCYTES AND CONVENTIONAL PACKED RED BLOOD CELLS IN BETA-THALASSEMIA MAJOR PATIENTS: A COMPARATIVE STUDY , 2016 .

[19]  C. Hollot,et al.  Models for the red blood cell lifespan , 2016, Journal of Pharmacokinetics and Pharmacodynamics.

[20]  S. Assmann,et al.  Effects of red-cell storage duration on patients undergoing cardiac surgery. , 2015, The New England journal of medicine.

[21]  Jeannie Callum,et al.  Age of transfused blood in critically ill adults. , 2015, The New England journal of medicine.

[22]  J. Widness,et al.  Mean remaining life span: a new clinically relevant parameter to assess the quality of transfused red blood cells , 2014, Transfusion.

[23]  T. Coates Physiology and pathophysiology of iron in hemoglobin-associated diseases. , 2014, Free radical biology & medicine.

[24]  S. Sheth,et al.  Red blood cell transfusions for thalassemia: results of a survey assessing current practice and proposal of evidence‐based guidelines , 2014, Transfusion.

[25]  L. Kovacs,et al.  Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial. , 2012, JAMA.

[26]  Q. Ran,et al.  Clinical Observation of Factors in the Efficacy of Blood Component Transfusion in Patients following Hematopoietic Stem Cell Transplantation , 2012, PloS one.

[27]  P. Brissot,et al.  Non-transferrin bound iron: a key role in iron overload and iron toxicity. , 2012, Biochimica et biophysica acta.

[28]  J. P. Perez Ruixo,et al.  Lifespan based indirect response models , 2012, Journal of Pharmacokinetics and Pharmacodynamics.

[29]  S. Duffull,et al.  Evaluation of red blood cell labelling methods based on a statistical model for red blood cell survival. , 2011, Journal of theoretical biology.

[30]  C. Prowse,et al.  A pilot study of the possibility and the feasibility of haemoglobin dosing with red blood cells transfusion , 2010, Vox sanguinis.

[31]  Jennifer L. Turi,et al.  Iron overload following red blood cell transfusion and its impact on disease severity. , 2009, Biochimica et biophysica acta.

[32]  A. Gaur,et al.  Transfusion of neocytes concentrate/pooled neocytes in β-thalassemic patients , 2008, Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion.

[33]  W. D. de Grip,et al.  Survival of red blood cells after transfusion: a comparison between red cells concentrates of different storage periods , 2008, Transfusion.

[34]  R. Baccoli,et al.  A mathematical model for the evaluation of amplitude of hemoglobin fluctuations in elderly anemic patients affected by myelodysplastic syndromes: correlation with quality of life and fatigue. , 2007, Leukemia research.

[35]  J. Porter Practical management of iron overload , 2001, British journal of haematology.

[36]  I. Papassotiriou,et al.  The Impact of Neocyte Transfusion in the Management of Thalassaemia , 1996, Vox sanguinis.

[37]  R. Herst,et al.  Comparison of a transfusion preparation of newly formed red cells and standard washed red cell transfusions in patients with homozygous β‐ thalassemia , 1994, Transfusion.

[38]  J. Davis,et al.  The Red Blood Cell , 1961, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.