论文信息 - Variables of patient‐controlled analgesia 4: the relevance of bolus dose size to supplement a background infusion

Variables of patient‐controlled analgesia 4: the relevance of bolus dose size to supplement a background infusion

A range of self‐administered demand doses of morphine (0.4, 0.7 and 1.0 mg) were prescribed to supplement a fixed‐rate infusion (1.5 mg/hour) for pain control after gynaecological surgery. The number of demand doses administered during the first 25 hours after surgery was not significantly influenced by size of demand dose. There was a significant linear trend to increasing amount of demanded morphine with increasing bolus size. These results cast doubt on the usefulness of the concept of a minimum effective analgesic concentration of morphine.

[1] G. Smith,et al. The control of acute postoperative pain. , 1989, British journal of anaesthesia.

[2] L E Mather,et al. Variables of patient‐controlled analgesia 1. bolus size , 1989, Anaesthesia.

[3] R. Glavin,et al. Ibuprofen in the management of postoperative pain. , 1986, British journal of anaesthesia.

[4] P. White,et al. EFFECTS OF A “BASAL” OPIOID INFUSION ON THE POSTOPERATIVE ANALGESIC REQUIREMENT , 1989 .

[5] R. Moore,et al. Relief of pain by infusion of morphine after operation , 1985 .

[6] B. J. Winer. Statistical Principles in Experimental Design , 1992 .

[7] M. Keeri-Szanto,et al. Drugs or drums: What relieves postoperative pain? , 1979, PAIN.

[8] L E Mather,et al. Variables of patient‐controlled analgesia 2. concurrent infusion , 1989, Anaesthesia.

[9] W. Nimmo,et al. Relief of pain by infusion of morphine after operation: does tolerance develop? , 1985, British medical journal.

[10] G. Smith,et al. Comparison of the Leicester Micropalliator and the Cardiff Palliator in the relief of postoperative pain. , 1987, British journal of anaesthesia.