Link between gut‐microbiome derived metabolite and shared gene‐effects with hepatic steatosis and fibrosis in NAFLD
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Rohit Loomba | Chi-Hua Chen | Jonathan Hooker | Nicholas Schork | Cynthia Hsu | Min-Tzu Lo | Claude B Sirlin | N. Schork | D. Brenner | C. Sirlin | Chi-Hua Chen | M. Lo | R. Loomba | V. Ajmera | J. Hooker | B. Schnabl | David A Brenner | Bernd Schnabl | Cyrielle Caussy | Amy Liu | Ricki Bettencourt | Veeral H Ajmera | Shirin Bassirian | Ethan Sy | Lisa Richards | R. Bettencourt | L. Richards | Shirin Bassirian | Amy Liu | Cynthia Hsu | Ethan Sy | C. Caussy | Cynthia L Hsu | Cynthia L. Hsu | Min-Tzu Lo | Veeral H. Ajmera
[1] S. Sookoian,et al. Meta‐analysis of the influence of I148M variant of patatin‐like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease , 2011, Hepatology.
[2] H. Nittono,et al. Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. , 2013, Journal of Hepatology.
[3] N. Schork,et al. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. , 2015, Gastroenterology.
[4] Shuzhao Li,et al. Amino Acid Metabolism is Altered in Adolescents with Nonalcoholic Fatty Liver Disease-An Untargeted, High Resolution Metabolomics Study. , 2016, The Journal of pediatrics.
[5] Corey D. DeHaven,et al. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. , 2009, Analytical chemistry.
[6] David Torrents,et al. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug , 2017, Nature Medicine.
[7] Markus Perola,et al. Genome-wide association study identifies multiple loci influencing human serum metabolite levels , 2012, Nature Genetics.
[8] Emily R. Davenport,et al. Genetic Determinants of the Gut Microbiome in UK Twins. , 2016, Cell host & microbe.
[9] K. Clément,et al. TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease , 2014, Nature Communications.
[10] S. Subramaniam,et al. Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study , 2015, Gut.
[11] H. Flint,et al. Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product , 2004, Applied and Environmental Microbiology.
[12] Peter M Visscher,et al. Power of the classical twin design revisited. , 2004, Twin research : the official journal of the International Society for Twin Studies.
[13] T. Lehtimäki,et al. Metabolic profiling of fatty liver in young and middle‐aged adults: Cross‐sectional and prospective analyses of the Young Finns Study , 2016, Hepatology.
[14] S. Caldwell,et al. Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds. , 2000, The American journal of medicine.
[15] Shelly C. Lu,et al. Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis. , 2017, Gastroenterology.
[16] N. Schork,et al. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis , 2017, The Journal of clinical investigation.
[17] G. Willemsen,et al. Familial Resemblance for Serum Metabolite Concentrations , 2013, Twin Research and Human Genetics.
[18] Anne M. Evans,et al. Organization of GC/MS and LC/MS metabolomics data into chemical libraries , 2010, J. Cheminformatics.
[19] N. Schork,et al. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study , 2016, Hepatology.
[20] Udo Hoffmann,et al. Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits , 2011, PLoS genetics.
[21] Amalio Telenti,et al. Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites , 2017, Nature Genetics.
[22] B. Roe,et al. A core gut microbiome in obese and lean twins , 2008, Nature.
[23] J. Bajaj,et al. Changes in the Intestinal Microbiome and Alcoholic and Nonalcoholic Liver Diseases: Causes or Effects? , 2016, Gastroenterology.
[24] V. Teplova,et al. Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils , 2012, Journal of Biomedical Science.
[25] Huijue Jia,et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention , 2017, Nature Medicine.
[26] M. Abraham,et al. Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis , 2012, Hepatology.
[27] N. Schork,et al. Heritability of nonalcoholic fatty liver disease. , 2009, Gastroenterology.
[28] J. Venter,et al. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. , 2019, Cell metabolism.
[29] Peter Donnelly,et al. Human metabolic profiles are stably controlled by genetic and environmental variation , 2011, Molecular Systems Biology.
[30] M. Pop,et al. Metagenomic Analysis of the Human Distal Gut Microbiome , 2006, Science.
[31] Lixin Zhu,et al. Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH , 2013, Hepatology.
[32] D. Brenner,et al. Association between novel MRI‐estimated pancreatic fat and liver histology‐determined steatosis and fibrosis in non‐alcoholic fatty liver disease , 2013, Alimentary pharmacology & therapeutics.
[33] A. Sanyal,et al. Nonalcoholic steatohepatitis is associated with a state of betaine‐insufficiency , 2017, Liver international : official journal of the International Association for the Study of the Liver.
[34] John P. Overington,et al. An atlas of genetic influences on human blood metabolites , 2014, Nature Genetics.
[35] Rohit Loomba,et al. The global NAFLD epidemic , 2013, Nature Reviews Gastroenterology &Hepatology.
[36] Richard A. Flavell,et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity , 2012, Nature.
[37] Beiwen Zheng,et al. Alterations of the human gut microbiome in liver cirrhosis , 2014, Nature.
[38] V. Wong,et al. Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta‐analysis , 2017, Hepatology.
[39] Hong-wei Zhang,et al. Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults , 2016, Scientific Reports.
[40] P. Paci,et al. Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta‐omics‐based approach , 2017, Hepatology.
[41] M. Uhlén,et al. Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease , 2014, Nature Communications.
[42] Peter Donnelly,et al. A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection , 2011, PLoS genetics.
[43] L. Henry,et al. Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes , 2016, Hepatology.
[44] D. Brenner,et al. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non‐alcoholic fatty liver disease – MRI accurately quantifies hepatic steatosis in NAFLD , 2012, Alimentary pharmacology & therapeutics.
[45] Lawrence A. David,et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota , 2016, Hepatology.