Elastic Superhydrophobic and Photocatalytic Active Films Used as Blood Repellent Dressing

Durable and biocompatible superhydrophobic surfaces are of significant potential use in biomedical applications. Here, a nonfluorinated, elastic, superhydrophobic film that can be used for medical wound dressings to enhance their hemostasis function is introduced. The film is formed by titanium dioxide nanoparticles, which are chemically crosslinked in a poly(dimethylsiloxane) (PDMS) matrix. The PDMS crosslinks result in large strain elasticity of the film, so that it conforms to deformations of the substrate. The photocatalytic activity of the titanium dioxide provides surfaces with both self-cleaning and antibacterial properties. Facile coating of conventional wound dressings is demonstrated with this composite film and then resulting improvement for hemostasis. High gas permeability and water repellency of the film will provide additional benefit for medical applications.

[1]  M. Khorasani,et al.  Laser surface modification of polymers to improve biocompatibility : HEMA grafted PDMS, in vitro assay-III , 1999 .

[2]  M. Naito,et al.  Antibacterial metal implant with a TiO2‐conferred photocatalytic bactericidal effect against Staphylococcus aureus , 2009 .

[3]  Xuan Lai,et al.  Superhydrophobic/Superhydrophilic Janus Fabrics Reducing Blood Loss , 2018, Advanced healthcare materials.

[4]  H. Butt,et al.  Super liquid-repellent gas membranes for carbon dioxide capture and heart–lung machines , 2013, Nature Communications.

[5]  J. Mano,et al.  Micro/nano-structured superhydrophobic surfaces in the biomedical field: part II: applications overview. , 2015, Nanomedicine.

[6]  E. Hrncír,et al.  Surface tension of blood. , 1997, Physiological research.

[7]  Jin Zhai,et al.  Super-Hydrophobic PDMS Surface with Ultra-Low Adhesive Force† , 2005 .

[8]  R. Haag,et al.  Supramolecular Polymers as Surface Coatings: Rapid Fabrication of Healable Superhydrophobic and Slippery Surfaces , 2014, Advanced materials.

[9]  Liping Chen,et al.  Enhanced Photocatalytic Reaction at Air-Liquid-Solid Joint Interfaces. , 2017, Journal of the American Chemical Society.

[10]  Yongmei Zheng,et al.  Icephobic/Anti‐Icing Properties of Micro/Nanostructured Surfaces , 2012, Advanced materials.

[11]  A. Hozumi,et al.  A statically oleophilic but dynamically oleophobic smooth nonperfluorinated surface. , 2012, Angewandte Chemie.

[12]  Eugene K. Lee,et al.  Reduced Blood Coagulation on Roll‐to‐Roll, Shrink‐Induced Superhydrophobic Plastics , 2016, Advanced healthcare materials.

[13]  J. Mano,et al.  Micro-/nano-structured superhydrophobic surfaces in the biomedical field: part I: basic concepts and biomimetic approaches. , 2015, Nanomedicine.

[14]  A. Dalu,et al.  A comparison of the inflammatory response to a polydimethylsiloxane implant in male and female Balb/c mice. , 2000, Biomaterials.

[15]  James R. Hall.  Blood Contamination of Anesthesia Equipment and Monitoring Equipment , 1994, Anesthesia and analgesia.

[16]  Darryl Y Sasaki,et al.  Poly(dimethylsiloxane) thin films as biocompatible coatings for microfluidic devices: cell culture and flow studies with glial cells. , 2005, Journal of biomedical materials research. Part A.

[17]  S. Franssila,et al.  Superhydrophobic Blood‐Repellent Surfaces , 2018, Advanced materials.

[18]  C. Barras,et al.  Nitinol - its use in vascular surgery and other applications. , 2000, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[19]  Chandan K Sen,et al.  Revisiting the essential role of oxygen in wound healing. , 2003, American journal of surgery.

[20]  Tom Duerig,et al.  Self-expanding nitinol stents: material and design considerations , 2004, European Radiology.

[21]  Akira Fujishima,et al.  Titanium dioxide photocatalysis , 2000 .

[22]  S. Hatzikiriakos,et al.  Effect of Extreme Wettability on Platelet Adhesion on Metallic Implants: From Superhydrophilicity to Superhydrophobicity. , 2016, ACS applied materials & interfaces.

[23]  Youmin Hou,et al.  Recurrent filmwise and dropwise condensation on a beetle mimetic surface. , 2015, ACS nano.

[24]  B. Hardman,et al.  Risk of blood contamination and injury to operating room personnel. , 1991, Annals of surgery.

[25]  J. Humbeeck,et al.  Critical overview of Nitinol surfaces and their modifications for medical applications. , 2008, Acta biomaterialia.

[26]  Robin H. A. Ras,et al.  Free-decay and resonant methods for investigating the fundamental limit of superhydrophobicity , 2013, Nature Communications.

[27]  C. Cui,et al.  Fabrication and biocompatibility of nano-TiO2/titanium alloys biomaterials , 2005 .

[28]  Bo Zhang,et al.  Guided Self-Propelled Leaping of Droplets on a Micro-Anisotropic Superhydrophobic Surface. , 2016, Angewandte Chemie.

[29]  C. Wen,et al.  Biocompatibility of TiO2 nanotubes with different topographies. , 2014, Journal of biomedical materials research. Part A.

[30]  J. Chen,et al.  Anti-icing surfaces based on enhanced self-propelled jumping of condensed water microdroplets. , 2013, Chemical communications.

[31]  M. Bourham,et al.  Plasma and Antimicrobial Treatment of Nonwoven Fabrics for Surgical Gowns , 2004 .

[32]  M. Wong,et al.  Characteristics, apatite-forming ability and corrosion resistance of NiTi surface modified by AC anodization , 2007 .

[33]  P. J. Hill,et al.  Highly fluorinated chemicals in functional textiles can be replaced by re-evaluating liquid repellency and end-user requirements , 2019, Journal of Cleaner Production.

[34]  Giuseppe Gigli,et al.  Superhydrophobicity due to the hierarchical scale roughness of PDMS surfaces. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[35]  L. Dasi,et al.  Hemocompatibility of Superhemophobic Titania Surfaces , 2017, Advanced healthcare materials.

[36]  Allen Pei,et al.  Efficient electrocatalytic CO2 reduction on a three-phase interface , 2018, Nature Catalysis.

[37]  Edward J. Wolfrum,et al.  Bactericidal mode of titanium dioxide photocatalysis , 2000 .

[38]  M. Torabinejad,et al.  Dye leakage of four root end filling materials: effects of blood contamination. , 1994, Journal of endodontics.

[39]  H. Butt,et al.  A Photocatalytically Active Lubricant-Impregnated Surface. , 2017, Angewandte Chemie.

[40]  C. Sharma,et al.  Growth Rates and Spontaneous Navigation of Condensate Droplets Through Randomly Structured Textures. , 2017, ACS nano.

[41]  R. N. Wenzel.  RESISTANCE OF SOLID SURFACES TO WETTING BY WATER , 1936 .

[42]  Menghan Ma,et al.  Local delivery of antimicrobial peptides using self-organized TiO2 nanotube arrays for peri-implant infections. , 2012, Journal of biomedical materials research. Part A.

[43]  H. Butt,et al.  Stable Hydrophobic Metal‐Oxide Photocatalysts via Grafting Polydimethylsiloxane Brush , 2017, Advanced materials.

[44]  Lei Jiang,et al.  Asymmetric ratchet effect for directional transport of fog drops on static and dynamic butterfly wings. , 2014, ACS nano.