论文信息 - The Response of the Metabolic Network of the Red Blood Cell to Pyruvate Kinase Deficiency

The Response of the Metabolic Network of the Red Blood Cell to Pyruvate Kinase Deficiency

The response of the metabolic network of human red blood cell is investigated using the E-Cell simulation system when pyruvate kinase (PK) is deficient. The results that several downstream metabolites of the glycolysis pathway accumulate are in a good agreement with experimental data reported in literatures. This accumulation results in the reaction that phosphoglycerate kinase (PGK) catalyzes reversing its direction. Mathematical analysis to the simulation results shows that the PGK-catalyzing reaction reversing its direction happens simultaneously with an abrupt change of the second derivative of the ATP quantity

Zuhong Lu | Zuhong Lu | Xiaoliang Sun | X. Sun

[1] A. Arkin,et al. Genetic "code": representations and dynamical models of genetic components and networks. , 2002, Annual review of genomics and human genetics.

[2] Masaru Tomita,et al. Computer Simulation of Human Erythrocyte Using the E-CELL System , 1999 .

[3] M. Lakomek,et al. Erythrocyte pyruvate kinase- and glucose phosphate isomerase deficiency: perturbation of glycolysis by structural defects and functional alterations of defective enzymes and its relation to the clinical severity of chronic hemolytic anemia. , 1997, Biophysical chemistry.

[4] M. Tomita. Whole-cell simulation: a grand challenge of the 21st century. , 2001, Trends in biotechnology.

[5] E. El-demerdash,et al. Probucol attenuates oxidative stress and energy decline in isoproterenol-induced heart failure in rat. , 2005, Pharmacological research.

[6] K. Dong,et al. Novel nucleotide‐binding sites in ATP‐sensitive potassium channels formed at gating interfaces , 2005, The EMBO journal.

[7] M. Carlson,et al. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? , 1998, Annual review of biochemistry.