Short-wavelength color visual fields in glaucoma suspects at risk.

Glaucoma suspect eyes were seen during a five-year study on color visual fields that used a 440-nm test on a bright-yellow background (96 normal eyes, 55 suspect eyes, and 110 eyes that developed glaucoma). The predictive ability of the test was assessed in 25 eyes followed up for more than one year, five of which developed glaucoma. These five eyes and those at high risk showed higher mean defect (P < .0001) and number of defective points (P < .0001) than the other suspect groups, which were not significantly different from normal eyes. The mean defects (+/- standard deviations) and average number of defective points were 1.4 +/- 2.3 dB with 8.9 points (low-risk eyes), 1.1 +/- 1.2 dB with 8.0 points (medium-risk eyes), 6.7 +/- 2.8 dB with 27.7 points (high-risk eyes), and 9.3 +/- 1.8 dB with 39.4 points (eyes that developed glaucoma). Normal eyes had an average of 3.4 defective points. These results were similar when all 55 suspect eyes were analyzed. Color visual fields identify early functional loss in eyes at greatest risk for primary open-angle glaucoma.

[1]  W. Spileers,et al.  Peripheral color contrast. A new screening test for preglaucomatous visual loss. , 1991, Investigative ophthalmology & visual science.

[2]  P A Sample,et al.  Progressive color visual field loss in glaucoma. , 1992, Investigative ophthalmology & visual science.

[3]  S. Duke-Elder.  Textbook of Ophthalmology , 1950 .

[4]  P. Lichter.  Variability of expert observers in evaluating the optic disc. , 1976, Transactions of the American Ophthalmological Society.

[5]  M. Gordon,et al.  Glaucomatous visual field damage. Luminance and color-contrast sensitivities. , 1990, Investigative ophthalmology & visual science.

[6]  J Katz,et al.  Risk factors for the development of glaucomatous visual field loss in ocular hypertension. , 1994, Archives of ophthalmology.

[7]  A. Ringvold,et al.  The probability of having glaucoma at different IOP levels , 1991, Acta ophthalmologica.

[8]  P A Sample,et al.  Acquired dyschromatopsia in glaucoma. , 1986, Survey of ophthalmology.

[9]  S. Drance,et al.  Multivariate analysis in glaucoma. Use of discriminant analysis in predicting glaucomatous visual field damage. , 1981, Archives of ophthalmology.

[10]  E. Perkins,et al.  The Bedford glaucoma survey. I. Long-term follow-up of borderline cases. , 1973, The British journal of ophthalmology.

[11]  R. Weinreb,et al.  A practical method for obtaining an index of lens density with an automated perimeter. , 1989, Investigative ophthalmology & visual science.

[12]  N. Nielsen,et al.  OCULAR HYPERTENSION. A 15‐YEAR FOLLOW‐UP , 1978, Acta ophthalmologica.

[13]  G. Trick,et al.  Motion perception is abnormal in primary open-angle glaucoma and ocular hypertension. , 1990, Investigative ophthalmology & visual science.

[14]  C W Tyler,et al.  Specific deficits of flicker sensitivity in glaucoma and ocular hypertension. , 1981, Investigative ophthalmology & visual science.

[15]  J. Mollon,et al.  Colour illusion and evidence for interaction between cone mechanisms , 1975, Nature.

[16]  P A Sample,et al.  Color perimetry for assessment of primary open-angle glaucoma. , 1990, Investigative ophthalmology & visual science.

[17]  R. M. Boynton,et al.  Isolating the color vision loss in primary open-angle glaucoma. , 1988, American journal of ophthalmology.

[18]  P A Sample,et al.  The aging lens: in vivo assessment of light absorption in 84 human eyes. , 1988, Investigative ophthalmology & visual science.

[19]  M. Marrè.  Clinical examination of the three color vision mechanisms in acquired color vision defects. , 1972, Modern problems in ophthalmology.

[20]  R. Hitchings,et al.  Color vision defects in ocular hypertension and glaucoma. Quantification with a computer-driven color television system. , 1988, Archives of ophthalmology.

[21]  M. Kass,et al.  Prognostic significance of optic disk cupping in ocular hypertensive patients. , 1980, American journal of ophthalmology.

[22]  G. Wald,et al.  The participation of different types of cones in human light and dark adaptation. , 1955, American journal of ophthalmology.

[23]  W M Hart,et al.  Multivariate analysis of the risk of glaucomatous visual field loss. , 1979, Archives of ophthalmology.

[24]  J Caprioli.  Discrimination between normal and glaucomatous eyes. , 1992, Investigative ophthalmology & visual science.

[25]  J. Miller,et al.  Risk factors favoring the development of glaucomatous visual field loss in ocular hypertension. , 1980, Survey of ophthalmology.

[26]  J D Mollon,et al.  Reversed effect of adapting stimuli on visual sensitivity , 1980, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[27]  E. Linnér,et al.  Ocular hypertension , 1987, Acta ophthalmologica.

[28]  G. Dunkelberger,et al.  Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. , 1989, American journal of ophthalmology.