Optimization of exposure conditions for medical ultrasound.

Optimum exposure conditions are values of acoustic exposure parameters (e.g., intensity, pressure amplitude, time) which yield maximum net medical benefit in a therapeutic or diagnostic procedure. It is generally agreed that if the exposure values are too low, the procedures are ineffective, while if they are too high, harm will result. However, little quantitative information exists on what specific values the parameters should have to give greatest net benefit in various applications. The determination of optimum exposure conditions is an important goal, but the process is likely to be a long one, requiring efforts by many individuals and groups. In this review several approaches to the problem are discussed, and difficulties are pointed out.

[1]  A. R. Williams.  Ultrasound : biological effects and potential hazards , 1983 .

[2]  K. Parker,et al.  Letters to the , 1997 .

[3]  Wesley L. Nyborg,et al.  Physical Mechanisms for Biological Effects of Sound , 1965 .

[4]  Douglas L. Miller.  Gas body activation , 1984 .

[5]  M. Dyson.  Non-thermal cellular effects of ultrasound. , 1982, The British journal of cancer. Supplement.

[6]  W L Nyborg,et al.  Nearfield of a piston source of ultrasound in an absorbing medium. , 1985, The Journal of the Acoustical Society of America.

[7]  V. Ciaravino.  Biological Effects of Ultrasound: Mechanisms and Clinical Implications(NCRP Report No. 74) , 1986 .

[8]  Edwin L. Carstensen,et al.  Biological effects of ultrasound , 1974 .

[9]  D. R. Bacon,et al.  Characteristics of a PVDF Membrane Hydrophone for Use in the Range 1-100 MHz , 1982, IEEE Transactions on Sonics and Ultrasonics.

[10]  D. Miller,et al.  Platelet aggregation induced by ultrasound under specialized conditions in vitro. , 1979, Science.

[11]  D. Benwell,et al.  Essentials of Medical Ultrasound , 1982, Medical Methods.

[12]  G. Haar,et al.  Biological effects of ultrasound: mechanisms and clinical implications , 1985 .

[13]  R. M. Moore,et al.  Development of health risk evaluation data for diagnostic ultrasound: A historical perspective , 1984, Journal of clinical ultrasound : JCU.

[14]  R. C. Eggleton,et al.  Threshold ultrasonic dosages for structural changes in the mammalian brain. , 1970, The Journal of the Acoustical Society of America.

[15]  J. Driller,et al.  Ultrasonic Hyperthermia for Ophthalmic Therapy , 1984, IEEE Transactions on Sonics and Ultrasonics.

[16]  Wesley L. Nyborg,et al.  Physical Consequences of Ultrasound in Plant Tissues and Other Bio-Systems , 1975 .

[17]  E. Carstensen,et al.  Effects of ultrasound on Drosophila: III. Exposure of larvae to low-temporal-average-intensity, pulsed irradiation. , 1981, Ultrasound in medicine & biology.

[18]  F Dunn,et al.  Nonlinear ultrasonic propagation in biological media. , 1982, The British journal of cancer. Supplement.

[19]  P. A. Lewin,et al.  Miniature piezoelectric polymer ultrasonic hydrophone probes , 1981 .

[20]  H. G. Flynn.  Generation of transient cavities in liquids by microsecond pulses of ultrasound , 1982 .

[21]  Justus F. Lehmann.  Therapeutic heat and cold , 1975 .

[22]  P. Edmonds.  Physical mechanisms for biological effects of ultrasound: By W. L. Nyborg. DHEW Publication (FDA) 78-8062,59 pp., available without charge from BRH Technical Information Staff (HFX-25), 5600 Fishers Lane, Rockville, MD 20857 (Limited distribution) , 1978 .

[23]  G. Kossoff,et al.  Temporal peak intensity as a critical parameter in ultrasound dosimetry. , 1984, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[24]  Shrinivas G. Joshi,et al.  Ultrasonic instrument for measuring bolt stress , 1984 .

[25]  Mitchell M. Goodsitt,et al.  Continuous waves generated by focused radiators , 1981 .

[26]  Douglas L. Miller.  The botanical effects of ultrasound: A review , 1983 .

[27]  Morton W. Miller,et al.  The exposure vessel as a factor in ultrasonically-induced mammalian cell lysis--II. An explanation of the need to rotate exposure tubes. , 1982, Ultrasound in medicine & biology.

[28]  D. Watmough,et al.  Observations of ultrasound-induced effects in the fish Xiphophorous maculatus. , 1983, Ultrasound in medicine & biology.

[29]  L A Crum,et al.  Growth of air bubbles in tissue by rectified diffusion. , 1982, Physics in medicine and biology.

[30]  W. K. Law,et al.  Demonstration of nonlinear acoustical effects at biomedical frequencies and intensities. , 1980, Ultrasound in medicine & biology.

[31]  C R Hill,et al.  Ultrasonically induced cavitation in vivo. , 1982, The British journal of cancer. Supplement.

[32]  D. Miller,et al.  Further investigations of ATP release from human erythrocytes exposed to ultrasonically activated gas-filled pores. , 1983, Ultrasound in medicine & biology.