Fluorescently tagged polymer bioconjugates from protein derived macroinitiators.

BSA and lysozyme have been transformed into macroinitiators for living radical polymerisation and used to produce well-defined bioconjugates which can be fluorescently labelled providing a versatile strategy for the preparation of bioconjugates which is complementary to traditional PEGylation.

[1]  David J Brayden,et al.  Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion , 2006 .

[2]  Sébastien Perrier,et al.  Macromolecular design via réversible addition-fragmentation chain transfer (RAFT)/Xanthates (MADIX) polymerization , 2005 .

[3]  H. Maynard,et al.  In situ preparation of protein-"smart" polymer conjugates with retention of bioactivity. , 2005, Journal of the American Chemical Society.

[4]  Lei Tao,et al.  Design and synthesis of N-maleimido-functionalized hydrophilic polymers via copper-mediated living radical polymerization: a suitable alternative to PEGylation chemistry. , 2005, Journal of the American Chemical Society.

[5]  W. Huck,et al.  Polymer brushes via surface-initiated polymerizations. , 2004, Chemical Society reviews.

[6]  Lei Tao,et al.  Alpha-aldehyde terminally functional methacrylic polymers from living radical polymerization: application in protein conjugation "pegylation". , 2004, Journal of the American Chemical Society.

[7]  Lei Tao,et al.  A new approach to bioconjugates for proteins and peptides ("pegylation") utilising living radical polymerisation. , 2004, Chemical communications.

[8]  M. Francis,et al.  Practical synthetic route to functionalized rhodamine dyes. , 2003, Organic letters.

[9]  J. M. Harris,et al.  Effect of pegylation on pharmaceuticals , 2003, Nature Reviews Drug Discovery.

[10]  Veronese Fm,et al.  Introduction and overview of peptide and protein pegylation. , 2002 .

[11]  Francesco M Veronese,et al.  Polyethylene glycol-superoxide dismutase, a conjugate in search of exploitation. , 2002, Advanced drug delivery reviews.

[12]  M. Bentley,et al.  Chemistry for peptide and protein PEGylation. , 2002, Advanced drug delivery reviews.

[13]  M. Sawamoto,et al.  Metal-catalyzed living radical polymerization. , 2001, Chemical reviews.

[14]  E. Harth,et al.  New polymer synthesis by nitroxide mediated living radical polymerizations. , 2001, Chemical reviews.

[15]  M. Nakajima,et al.  Mechanism of bovine serum albumin aggregation during ultrafiltration. , 2001, Biotechnology and bioengineering.

[16]  K. Matyjaszewski,et al.  Atom transfer radical polymerization. , 2001, Chemical reviews.

[17]  F. Davis,et al.  Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. , 1977, The Journal of biological chemistry.

[18]  J. Janatova,et al.  The heterogeneity of bovine albumin with respect to sulfhydryl and dimer content. , 1968, The Journal of biological chemistry.