Phytochemicals and bioactive compounds effective against acute myeloid leukemia: A systematic review

[1]  P. M. Aja,et al.  Antioxidant, phytochemical, and therapeutic properties of medicinal plants: a review , 2023, International Journal of Food Properties.

[2]  Nitya Sharma,et al.  Luteolin: A flavone with myriads of bioactivities and food applications , 2023, Food Bioscience.

[3]  M. Swaminathan,et al.  Update on the role of gemtuzumab-ozogamicin in the treatment of acute myeloid leukemia , 2023, Therapeutic advances in hematology.

[4]  Ching-Dong Chang,et al.  Potentiation of Differentiation and Apoptosis in a Human Promyelocytic Leukemia Cell Line by Garlic Essential Oil and Its Organosulfur Compounds , 2020, AntiCancer Research.

[5]  Wei Chang,et al.  Friedelin inhibits the growth and metastasis of human leukemia cells via modulation of MEK/ERK and PI3K/AKT signalling pathways. , 2020, Journal of B.U.ON. : official journal of the Balkan Union of Oncology.

[6]  M. Muñoz,et al.  The Neurokinin-1 Receptor Antagonist Aprepitant, a New Drug for the Treatment of Hematological Malignancies: Focus on Acute Myeloid Leukemia , 2020, Journal of clinical medicine.

[7]  U. Kees,et al.  Potent antileukemic activity of curaxin CBL0137 against MLL‐rearranged leukemia , 2020, International journal of cancer.

[8]  A. Sorolla,et al.  From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds , 2020, Biomolecules.

[9]  N. Gray,et al.  Effects of the multi‐kinase inhibitor midostaurin in combination with chemotherapy in models of acute myeloid leukaemia , 2020, Journal of cellular and molecular medicine.

[10]  R. Friedman,et al.  Deciphering the molecular mechanism of FLT3 resistance mutations. , 2020, The FEBS journal.

[11]  M. Diederich,et al.  Petromurin C Induces Protective Autophagy and Apoptosis in FLT3-ITD-Positive AML: Synergy with Gilteritinib , 2020, Marine drugs.

[12]  F. Uckun,et al.  A Phase 1B Clinical Study of Combretastatin A1 Diphosphate (OXi4503) and Cytarabine (ARA-C) in Combination (OXA) for Patients with Relapsed or Refractory Acute Myeloid Leukemia , 2019, Cancers.

[13]  Q. Liu,et al.  Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models , 2019, Investigational New Drugs.

[14]  A. Wei,et al.  New drugs creating new challenges in acute myeloid leukemia , 2019, Genes, chromosomes & cancer.

[15]  J. Rothberg,et al.  LAM-003, a new drug for treatment of tyrosine kinase inhibitor-resistant FLT3-ITD-positive AML. , 2019, Blood advances.

[16]  T. Ketela,et al.  Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response , 2019, Science Translational Medicine.

[17]  J. Zeidner,et al.  Cyclin-dependent kinase (CDK) 9 and 4/6 inhibitors in acute myeloid leukemia (AML): a promising therapeutic approach , 2019, Expert opinion on investigational drugs.

[18]  M. Santos-Silva,et al.  MICONIDINE acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells , 2019, Investigational New Drugs.

[19]  Yongping Song,et al.  Gilteritinib: a novel FLT3 inhibitor for acute myeloid leukemia , 2019, Biomarker Research.

[20]  Zhang-zhen Shi,et al.  Antitumor effects of helenalin in doxorubicin-resistant leukemia cells are mediated via mitochondrial mediated apoptosis, loss of mitochondrial membrane potential, inhibition of cell migration and invasion and downregulation of PI3-kinase/AKT/m-TOR signalling pathway. , 2019, Journal of B.U.ON. : official journal of the Balkan Union of Oncology.

[21]  F. Pichiorri,et al.  The Bcl‐2 inhibitor venetoclax inhibits Nrf2 antioxidant pathway activation induced by hypomethylating agents in AML , 2019, Journal of cellular physiology.

[22]  Jian Huang,et al.  Abivertinib, a novel BTK inhibitor: anti-leukemia effects and synergistic efficacy with Homoharringtonine in acute myeloid leukemia. , 2019, Cancer letters.

[23]  Shuangnian Xu,et al.  Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics. , 2019, Chemico-biological interactions.

[24]  M. Gottesman,et al.  Heterogeneity in refractory acute myeloid leukemia , 2019, Proceedings of the National Academy of Sciences.

[25]  Lianmei Zhao,et al.  Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells , 2019, Nutrition and cancer.

[26]  M. Rehman,et al.  Natural products against cancer: Review on phytochemicals from marine sources in preventing cancer , 2019, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.

[27]  P. Su,et al.  Friedelane-type triterpene cyclase in celastrol biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast. , 2019, The New phytologist.

[28]  A. Janecka,et al.  Helenalin - A Sesquiterpene Lactone with Multidirectional Activity. , 2019, Current drug targets.

[29]  Shintaro Iwasaki,et al.  The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA. , 2019, Molecular cell.

[30]  F. Marofi,et al.  Leukemia therapy by flavonoids: Future and involved mechanisms , 2018, Journal of cellular physiology.

[31]  S. Aziz,et al.  Application of sesquiterpene lactone: A new promising way for cancer therapy based on anticancer activity. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[32]  Z. Estrov,et al.  Sorafenib Combined with 5‐azacytidine in Older Patients with Untreated FLT3‐ITD Mutated Acute Myeloid Leukemia , 2018, American journal of hematology.

[33]  Tao Zhang,et al.  Evaluation of curcumin, a natural product in turmeric, on Burkitt lymphoma and acute myeloid leukemia cancer stem cell markers. , 2018, Future oncology.

[34]  L. Botana,et al.  From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds , 2018, Front. Pharmacol..

[35]  S. Jang,et al.  The Combination of Flavokawain B and Daunorubicin Induces Apoptosis in Human Myeloid Leukemic Cells by Modifying NF-κB. , 2018, Anticancer research.

[36]  L. Orozco,et al.  Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells. , 2018, Oncology letters.

[37]  Shanshan Zhu,et al.  Sulforaphane Induces Apoptosis of Acute Human Leukemia Cells Through Modulation of Bax, Bcl-2 and Caspase-3 , 2018 .

[38]  P. Spagnuolo,et al.  Diosmetin Induces Apoptosis of Acute Myeloid Leukemia Cells. , 2018, Molecular pharmaceutics.

[39]  A. Coulibaly,et al.  The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression , 2018, PloS one.

[40]  Jingru Zhang,et al.  Cell Cycle Arrest and Apoptosis Induction Activity of Nitidine Chloride on Acute Myeloid Leukemia Cells. , 2018, Medicinal chemistry (Shariqah (United Arab Emirates)).

[41]  F. Ravandi,et al.  A phase 1 trial of vadastuximab talirine as monotherapy in patients with CD33-positive acute myeloid leukemia. , 2018, Blood.

[42]  Ling Li,et al.  Combination of betulinic acid and chidamide inhibits acute myeloid leukemia by suppression of the HIF1α pathway and generation of reactive oxygen species , 2017, Oncotarget.

[43]  Shun-Fa Yang,et al.  Tricetin Induces Apoptosis of Human Leukemic HL-60 Cells through a Reactive Oxygen Species-Mediated c-Jun N-Terminal Kinase Activation Pathway , 2017, International journal of molecular sciences.

[44]  I. Berindan‐Neagoe,et al.  Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer , 2017, International journal of molecular sciences.

[45]  I. Flinn,et al.  Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia. , 2017, Blood.

[46]  Dan Sun,et al.  Novel Curcumin Liposome Modified with Hyaluronan Targeting CD44 Plays an Anti-Leukemic Role in Acute Myeloid Leukemia in Vitro and in Vivo. , 2017, ACS applied materials & interfaces.

[47]  D. Nath,et al.  Chemopreventive Potential of Major Flavonoid Compound of Methanolic Bark Extract of Saraca asoca (Roxb.) in Benzene-induced Toxicity of Acute Myeloid Leukemia Mice , 2017, Pharmacognosy magazine.

[48]  N. Toyang,et al.  HLBT-100: a highly potent anti-cancer flavanone from Tillandsia recurvata (L.) L. , 2017, Cancer Cell International.

[49]  R. Hills,et al.  A randomized assessment of adding the kinase inhibitor lestaurtinib to first-line chemotherapy for FLT3-mutated AML. , 2017, Blood.

[50]  J. Pourahmad,et al.  Chrysin as an Anti-Cancer Agent Exerts Selective Toxicity by Directly Inhibiting Mitochondrial Complex II and V in CLL B-lymphocytes , 2017, Cancer investigation.

[51]  Le Quoc Thang,et al.  20-Hydroxyecdysone from Dacrycarpus imbricatus bark inhibits the proliferation of acute myeloid leukemia cells. , 2017, Asian Pacific journal of tropical medicine.

[52]  Y. Zhang,et al.  Oridonin effectively reverses the drug resistance of cisplatin involving induction of cell apoptosis and inhibition of MMP expression in human acute myeloid leukemia cells , 2017, Saudi journal of biological sciences.

[53]  Juan Wang,et al.  Subcellular localization of DJ-1 in human HL-60 leukemia cells in response to diallyl disulfide treatment , 2016, Molecular medicine reports.

[54]  F. Estévez,et al.  Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species. , 2016, Chemico-biological interactions.

[55]  M. Diederich,et al.  Natural and Synthetic Flavonoids: Structure–Activity Relationship and Chemotherapeutic Potential for the Treatment of Leukemia , 2016, Critical reviews in food science and nutrition.

[56]  Hua Li,et al.  Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia , 2016, Scientific Reports.

[57]  Paola E. Ordóñez,et al.  Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. , 2016, Journal of natural products.

[58]  Chwan-Fwu Lin,et al.  Sophoraflavanone G Induces Apoptosis in Human Leukemia Cells and Blocks MAPK Activation. , 2016, The American journal of Chinese medicine.

[59]  Dalina Tanyong,et al.  Diallyl disulfide induces apoptosis and autophagy via mTOR pathway in myeloid leukemic cell line , 2016, Tumor Biology.

[60]  Debarshi Kar Mahapatra,et al.  PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives. , 2016, European journal of medicinal chemistry.

[61]  E. Bertin,et al.  Medicarpin and millepurpan, two flavonoids isolated from Medicago sativa, induce apoptosis and overcome multidrug resistance in leukemia P388 cells. , 2015, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[62]  T. Efferth,et al.  Cytotoxicity of three naturally occurring flavonoid derived compounds (artocarpesin, cycloartocarpesin and isobavachalcone) towards multi-factorial drug-resistant cancer cells. , 2015, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[63]  Y. Baran,et al.  The pleiotropic effects of fisetin and hesperetin on human acute promyelocytic leukemia cells are mediated through apoptosis, cell cycle arrest, and alterations in signaling networks , 2015, Tumor Biology.

[64]  Yanan Zhang,et al.  Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling. , 2015, International journal of clinical and experimental pathology.

[65]  W. Hung,et al.  The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells , 2015, Blood Cancer Journal.

[66]  Chunrong Yu,et al.  Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells , 2015, Oncotarget.

[67]  T. Lim,et al.  Genistein exerts anti-leukemic effects on genetically different acute myeloid leukemia cell lines by inhibiting protein synthesis and cell proliferation while inducing apoptosis – molecular insights from an iTRAQ™ quantitative proteomics study , 2015, Oncoscience.

[68]  X. Xiong,et al.  Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways , 2015, Acta Pharmacologica Sinica.

[69]  A. Conney,et al.  α-tomatine inhibits growth and induces apoptosis in HL-60 human myeloid leukemia cells , 2015, Molecular medicine reports.

[70]  S. Xiao,et al.  Naringenin suppresses K562 human leukemia cell proliferation and ameliorates Adriamycin-induced oxidative damage in polymorphonuclear leukocytes , 2015, Experimental and therapeutic medicine.

[71]  T. Huh,et al.  Induction of apoptosis by obovatol as a novel therapeutic strategy for acute myeloid leukemia. , 2014, International journal of molecular medicine.

[72]  I. Ionkova,et al.  Apoptotic mechanisms of the biotechnologically produced arylnaphtalene lignan justicidin B in the acute myeloid leukemia-derived cell line HL-60 , 2014, Pharmacological reports : PR.

[73]  G. Russo,et al.  The pleiotropic flavonoid quercetin: from its metabolism to the inhibition of protein kinases in chronic lymphocytic leukemia. , 2014, Food & function.

[74]  F. Estévez,et al.  Synthesis and effects on cell viability of flavonols and 3-methyl ether derivatives on human leukemia cells. , 2014, European journal of medicinal chemistry.

[75]  M. Grever,et al.  Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity , 2014, Leukemia.

[76]  M. Levis,et al.  Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants. , 2014, Blood.

[77]  G. McDougall,et al.  Differential Effects of Polyphenols on Proliferation and Apoptosis in Human Myeloid and Lymphoid Leukemia Cell Lines , 2013, Anti-cancer agents in medicinal chemistry.

[78]  Shun-Fa Yang,et al.  Hispolon induces apoptosis through JNK1/2-mediated activation of a caspase-8, -9, and -3-dependent pathway in acute myeloid leukemia (AML) cells and inhibits AML xenograft tumor growth in vivo. , 2013, Journal of agricultural and food chemistry.

[79]  Y. Mimaki,et al.  New cholestane glycosides and sterols from the underground parts of Chamaelirium luteum and their cytotoxic activity , 2013, Journal of Natural Medicines.

[80]  M. Caligiuri,et al.  Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia , 2013, Journal of Hematology & Oncology.

[81]  C. Dobrotă,et al.  Natural compounds with important medical potential found in Helleborus sp. , 2013, Central European Journal of Biology.

[82]  P. Dent,et al.  Resveratrol Sensitizes Acute Myelogenous Leukemia Cells to Histone Deacetylase Inhibitors through Reactive Oxygen Species-Mediated Activation of the Extrinsic Apoptotic Pathway , 2012, Molecular Pharmacology.

[83]  Jai-Sing Yang,et al.  Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway. , 2012, Oncology reports.

[84]  Yung-Hyun Choi,et al.  Apoptosis induction of U937 human leukemia cells by diallyl trisulfide induces through generation of reactive oxygen species , 2012, Journal of Biomedical Science.

[85]  J. Wood,et al.  The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML , 2012, Blood Cancer Journal.

[86]  Yanjie He,et al.  Resveratrol sensitized leukemia stem cell-like KG-1a cells to cytokine-induced killer cells-mediated cytolysis through NKG2D ligands and TRAIL receptors , 2012, Cancer biology & therapy.

[87]  Xianglin Shi,et al.  Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti‐leukaemic activity in nude mice through the PKB pathway , 2012, British journal of pharmacology.

[88]  B. Roth,et al.  Securinine, a Myeloid Differentiation Agent with Therapeutic Potential for AML , 2011, PloS one.

[89]  Yan-Hui Peng,et al.  [Mechanism of Fas/FasL signal transduction pathway in K562 cell apoptosis induced by diallyl disulfide]. , 2011, Zhongguo shi yan xue ye xue za zhi.

[90]  Y. Honma,et al.  Cyclopamine induces eosinophilic differentiation and upregulates CD44 expression in myeloid leukemia cells. , 2011, Leukemia research.

[91]  H. Hassan,et al.  Anti-Proliferative Activity of Synthetic Ajoene Analogues on Cancer Cell-Lines , 2011 .

[92]  K. Kathiresan,et al.  Anticancer Drugs from Marine Flora: An Overview , 2011, Journal of oncology.

[93]  Yi Tang,et al.  Role of Ras‐related C3 botulinum toxin substrate 2 (Rac2), NADPH oxidase and reactive oxygen species in diallyl disulphide‐induced apoptosis of human leukaemia HL‐60 cells , 2010, Clinical and experimental pharmacology & physiology.

[94]  Yi Tang,et al.  Diallyl disulfide induces apoptosis in human leukemia HL-60 cells through activation of JNK mediated by reactive oxygen. , 2010, Die Pharmazie.

[95]  G. Russo,et al.  Quercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients , 2010, British Journal of Cancer.

[96]  Sang-Un Choi,et al.  Effects of indirubin derivatives on the FLT3 activity and growth of acute myeloid leukemia cell lines , 2010 .

[97]  M. Peppelenbosch,et al.  Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy , 2010, Cell Death and Disease.

[98]  V. Grinev,et al.  Cytotoxic Effect of Flavonoids on Leukemia Cells and Normal Cells of Human Blood , 2009, Bulletin of Experimental Biology and Medicine.

[99]  Chi-Hsin Hsu,et al.  Anticancer drugs discovery and development from marine organism. , 2009, Current topics in medicinal chemistry.

[100]  Kim J. Png,et al.  The effect of cantharidins on leukemic stem cells , 2009, International journal of cancer.

[101]  Wei Liu,et al.  Berberine inhibits SDF-1-induced AML cells and leukemic stem cells migration via regulation of SDF-1 level in bone marrow stromal cells. , 2008, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[102]  Li Yang,et al.  Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation. , 2008, European journal of pharmacology.

[103]  Faten Merhi,et al.  Allium compounds, dipropyl and dimethyl thiosulfinates as antiproliferative and differentiating agents of human acute myeloid leukemia cell lines , 2008, Biologics : targets & therapy.

[104]  H. Ling,et al.  Inhibition of ERK and activation of p38 are involved in diallyl disulfide induced apoptosis of leukemia HL-60 cells , 2008, Archives of pharmacal research.

[105]  Y. Huang,et al.  [Effects of diallyl disulfide on differential expression of apoptosis-associated genes in leukemia cell line HL-60]. , 2007, Ai zheng = Aizheng = Chinese journal of cancer.

[106]  R. Kofler,et al.  Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1‐arrested and bcl‐2‐expressing acute lymphoblastic leukaemia cells , 2006, British journal of haematology.

[107]  S. Shen,et al.  Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade. , 2005, Biochemical pharmacology.

[108]  V. Mersch-Sundermann,et al.  Induction of apoptosis in tumor cells by naturally occurring sulfur-containing compounds. , 2005, Mutation research.

[109]  William H Gerwick,et al.  Marine natural products as anticancer drugs. , 2005, Molecular cancer therapeutics.

[110]  H. Hassan.  Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy. , 2004, Leukemia research.

[111]  G. Wilding,et al.  Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response. , 1995, Cancer research.

[112]  Saleem Ahmad,et al.  The chemistry of alkyl thiosulfinate esters. 9. Antithrombotic organosulfur compounds from garlic: structural, mechanistic, and synthetic studies , 1986 .

[113]  Mahendra K. Jain,et al.  The chemistry of alkyl thiosulfate esters. 8. (E,Z)-Ajoene: a potent antithrombotic agent from garlic , 1984 .

[114]  W. H. Kneedler.  COLCHICINE IN ACUTE MYELOGENOUS LEUKEMIA , 1945 .

[115]  Y. Tan,et al.  [Effects of diallyl disulfide on apoptosis of human leukemia K562 cells and expression of Fas, FasL and caspase-8]. , 2011, Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.

[116]  T. Ahmed,et al.  Homoharringtonine in patients with myelodysplastic syndrome (MDS) and MDS evolving to acute myeloid leukemia. , 1996, Leukemia.