Myocardial dna strand breaks are detected in biopsy tissues from patients with dilated cardiomyopathy

Background: Progressive damage of cardiomyocytes with interstitial and replacement fibrosis accompanied by less inflammatory cell infiltration is observed in patients with dilated cardiomyopathy (DCM), suggesting some other mechanisms rather than necrotic cell death.

[1]  M. Davies Apoptosis in cardiovascular disease. , 1997, Heart.

[2]  R. Virmani,et al.  Apoptosis in myocytes in end-stage heart failure. , 1996, The New England journal of medicine.

[3]  L. Gaboury,et al.  Apoptosis in pressure overload-induced heart hypertrophy in the rat. , 1996, The Journal of clinical investigation.

[4]  L. Richard,et al.  Apoptosis in target organs of hypertension. , 1995, Hypertension.

[5]  R. Kloner,et al.  Reperfusion injury induces apoptosis in rabbit cardiomyocytes. , 1994, The Journal of clinical investigation.

[6]  B. Stewart Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. , 1994, Journal of the National Cancer Institute.

[7]  R. Lockshin,et al.  Delayed internucleosomal DNA fragmentation in programmed cell death , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  S. Wahl,et al.  Differential regulation of human monocyte programmed cell death (apoptosis) by chemotactic factors and pro-inflammatory cytokines. , 1991, Journal of immunology.

[9]  W. Abelmann,et al.  The challenge of cardiomyopathy. , 1989, Journal of the American College of Cardiology.

[10]  A. Lerner,et al.  Coxsackievirus myocarditis--with special reference to acute and chronic effects. , 1985, Progress in cardiovascular diseases.

[11]  John Calvin Reed,et al.  Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. , 1996, Laboratory investigation; a journal of technical methods and pathology.

[12]  M. Lesch,et al.  Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure. , 1996, The American journal of pathology.

[13]  H. Horvitz,et al.  Mechanisms and functions of cell death. , 1991, Annual review of cell biology.

[14]  C. Kessler,et al.  Nonradioactive labeling of oligonucleotides in vitro with the hapten digoxigenin by tailing with terminal transferase. , 1991, Analytical biochemistry.