Experimental analysis of heart rate variability of long-recording electrocardiograms in normal subjects and patients with coronary artery disease and normal left ventricular function

The heart rate signal contains valuable information about cardiac health, which cannot be extracted without the use of appropriate computerized methods. This paper presents an analysis of various electrocardiograms, the aim of which is to categorize them into two distinct groups. Group A represents young male subjects with no prior occurrence of coronary disease events and Group B represents middle-aged male subjects who have symptomatic coronary artery disease without myocardial infarction and whose 12-lead ECGs do not contain any abnormalities, thus wrongly indicating a normal subject. Electrocardiographic recordings are approximately 2h in length and acquired under conditions that favor the stationarity of collected data. Linear and nonlinear characteristics are studied by applying several techniques including Fourier analysis, Correlation Dimension Estimation, Approximate Entropy, and the Discrete Wavelet Transform. The small variations of the diagnostic information given by each one of the methods as well as the slightly different conclusions among similar studies indicate the necessity of further investigation, combined use, and complementary application of different approaches.