A Randomized Crossover Trial of Tenoxicam Compared with Rofecoxib for Postoperative Dental Pain Control

Two non-steroidal anti-inflammatory drugs, tenoxicam and rofecoxib, were compared for the control of postoperative pain following surgical extraction of bilaterally and symmetrically impacted wisdom teeth performed under intravenous sedation and local anaesthesia. Thirty-five young fit adult patients received each analgesic treatment for four days in a randomized, crossover design. The results suggest statistically better pain relief for the selective COX-2 inhibitor rofecoxib compared to tenoxicam, a traditional NSAID. There were side-effects with both treatments. Abdominal discomfort was significantly more common following rofecoxib compared to tenoxicam. Both analgesics were acceptable to most participants in the trial.

[1]  Y. Güneş,et al.  [Cyclooxygenase-2 inhibitors in postoperative pain management]. , 2004, Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology.

[2]  A. Rosenberg,et al.  Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor on pain management and recovery of function after knee replacement: a randomized controlled trial. , 2003, JAMA.

[3]  I. Gilron,et al.  Cyclooxygenase-2 Inhibitors in Postoperative Pain Management: Current Evidence and Future Directions , 2003, Anesthesiology.

[4]  G. Naglie,et al.  The cost effectiveness of rofecoxib and celecoxib in patients with osteoarthritis or rheumatoid arthritis. , 2003, Arthritis and rheumatism.

[5]  J. P. Houston,et al.  Alveolar osteitis: a review of its etiology, prevention, and treatment modalities. , 2002, General dentistry.

[6]  S. Lindahl,et al.  Cyclooxygenase Inhibition for Postoperative Analgesia , 2002, Anesthesia and analgesia.

[7]  R Day,et al.  Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. , 2000, The New England journal of medicine.

[8]  R. Makuch,et al.  Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. , 2000, JAMA.

[9]  J. Bolognese,et al.  Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs. , 1999, JAMA.

[10]  A. Merry,et al.  Tenoxicam and paracetamol-codeine combination after oral surgery: a prospective, randomized, double-blind, placebo-controlled study. , 1998, British journal of anaesthesia.

[11]  M. Zacharias,et al.  Comparison of oral and intravenous routes of giving tenoxicam. , 1998, The New Zealand dental journal.

[12]  K. Hargreaves,et al.  Effect of NSAID administration on tissue levels of immunoreactive prostaglandin E2, leukotriene B4, and (S)-flurbiprofen following extraction of impacted third molars , 1997, Pain.

[13]  R. Seymour,et al.  Evaluation of different doses of soluble ibuprofen and ibuprofen tablets in postoperative dental pain. , 1996, The British journal of oral & maxillofacial surgery.

[14]  P. vanderBijl,et al.  Analgesic and anti-inflammatory efficacy of tenoxicam and diclofenac sodium after third molar surgery. , 1996 .