Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics
暂无分享,去创建一个
M. Lindner | M. Irmler | O. Eickelberg | Arunima Sengupta | M. Königshoff | S. Hauck | Kenji Schorpp | W. Friess | J. Merl-Pham | A. Yildirim | A. Hilgendorff | H. Alsafadi | K. Hadian | O. Plettenburg | G. Burgstaller | L. Sarnová | M. Gregor | N. Kneidinger | Jürgen Behr | K. Heinzelmann | M. Jiroušková | Eduard Trenkenschuh | M. Stoleriu | Huilong Ma | J. Beckers | M. Gerckens | K. Schorpp | M. Wögrath | F. Pelizza | Kora Reichau | Armando-Marco Dworsky | Wolfgang Frieß | J. Behr | M. Jirouskova
[1] S. Walsh,et al. Nintedanib in Progressive Fibrosing Interstitial Lung Diseases. , 2019, The New England journal of medicine.
[2] S. Cook,et al. Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis , 2019, Science Translational Medicine.
[3] Naftali Kaminski,et al. Single Cell RNA-seq reveals ectopic and aberrant lung resident cell populations in Idiopathic Pulmonary Fibrosis , 2019, bioRxiv.
[4] M. Lindner,et al. Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling. , 2019, Journal of visualized experiments : JoVE.
[5] Damian Szklarczyk,et al. STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets , 2018, Nucleic Acids Res..
[6] M. Lindner,et al. Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis. , 2018, American journal of physiology. Lung cellular and molecular physiology.
[7] Leland McInnes,et al. UMAP: Uniform Manifold Approximation and Projection , 2018, J. Open Source Softw..
[8] B. Hinz,et al. The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication. , 2018, Matrix biology : journal of the International Society for Matrix Biology.
[9] Florian Heigwer,et al. Machine learning and image-based profiling in drug discovery , 2018, Current opinion in systems biology.
[10] Thomas Blaschke,et al. The rise of deep learning in drug discovery. , 2018, Drug discovery today.
[11] M. Lindner,et al. Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures. , 2018, American journal of physiology. Lung cellular and molecular physiology.
[12] O. Eickelberg,et al. Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation. , 2018, American journal of physiology. Lung cellular and molecular physiology.
[13] S. Nathan,et al. Global Gene Expression Analysis in an in vitro Fibroblast Model of Idiopathic Pulmonary Fibrosis Reveals Potential Role for CXCL14/CXCR4 , 2018, Scientific Reports.
[14] Leland McInnes,et al. UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction , 2018, ArXiv.
[15] M. Boshtam,et al. Plasminogen Activator Inhibitor Type‐1 as a Regulator of Fibrosis , 2018, Journal of cellular biochemistry.
[16] C. Henke,et al. IL-8 mediates idiopathic pulmonary fibrosis mesenchymal progenitor cell fibrogenicity , 2017, American journal of physiology. Lung cellular and molecular physiology.
[17] P. Selzer,et al. How Phenotypic Screening Influenced Drug Discovery: Lessons from Five Years of Practice. , 2017, Assay and drug development technologies.
[18] C. Harrison,et al. Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis , 2017, Front. Pharmacol..
[19] H. Schiller,et al. The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease , 2017, European Respiratory Journal.
[20] M. Lindner,et al. An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices. , 2017, American journal of physiology. Lung cellular and molecular physiology.
[21] Sebastian Thrun,et al. Dermatologist-level classification of skin cancer with deep neural networks , 2017, Nature.
[22] C. López-Otín,et al. Age-driven developmental drift in the pathogenesis of idiopathic pulmonary fibrosis , 2016, European Respiratory Journal.
[23] M. Lindner,et al. Surface proteome analysis identifies platelet derived growth factor receptor-alpha as a critical mediator of transforming growth factor-beta-induced collagen secretion. , 2016, The international journal of biochemistry & cell biology.
[24] L. Richeldi,et al. Idiopathic pulmonary fibrosis: Diagnosis, epidemiology and natural history , 2016, Respirology.
[25] Ata Mahjoubfar,et al. Deep Learning in Label-free Cell Classification , 2016, Scientific Reports.
[26] R. Raines,et al. Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells. , 2016, ACS chemical biology.
[27] S. Hauck,et al. The Proteome of Native Adult Müller Glial Cells From Murine Retina* , 2015, Molecular & Cellular Proteomics.
[28] N. Kaminski,et al. FK506-Binding Protein 10, a Potential Novel Drug Target for Idiopathic Pulmonary Fibrosis. , 2015, American journal of respiratory and critical care medicine.
[29] P. Spagnolo,et al. Idiopathic pulmonary fibrosis: Recent advances on pharmacological therapy. , 2015, Pharmacology and Therapeutics.
[30] Oliver Eickelberg,et al. Time- and compartment-resolved proteome profiling of the extracellular niche in lung injury and repair , 2015 .
[31] P. Loria,et al. Developing predictive assays: The phenotypic screening “rule of 3” , 2015, Science Translational Medicine.
[32] B. Morrissey,et al. Acute exacerbation of idiopathic pulmonary fibrosis-a review of current and novel pharmacotherapies. , 2015, Journal of thoracic disease.
[33] Don C Rockey,et al. Fibrosis--a common pathway to organ injury and failure. , 2015, The New England journal of medicine.
[34] S. Turner,et al. Proteomic Analysis of Altered Extracellular Matrix Turnover in Bleomycin-induced Pulmonary Fibrosis , 2014, Molecular & Cellular Proteomics.
[35] M. Lindner,et al. Multiplex Profiling of Cellular Invasion in 3D Cell Culture Models , 2013, PloS one.
[36] S. Friedman,et al. Therapy for Fibrotic Diseases: Nearing the Starting Line , 2013, Science Translational Medicine.
[37] Kevin Weiss,et al. Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. , 2012, American journal of respiratory and critical care medicine.
[38] Alexandra Naba,et al. Towards definition of an ECM parts list: an advance on GO categories. , 2012, Matrix biology : journal of the International Society for Matrix Biology.
[39] O. Eickelberg,et al. New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis , 2012, The Lancet.
[40] T. Wynn,et al. Mechanisms of fibrosis: therapeutic translation for fibrotic disease , 2012, Nature Medicine.
[41] M. Rogosnitzky,et al. Therapeutic potential of tranilast, an anti-allergy drug, in proliferative disorders. , 2012, Anticancer research.
[42] Thomas Delahais,et al. Applying contribution analysis: Lessons from five years of practice , 2012 .
[43] M. Ueffing,et al. Direct comparison of MS‐based label‐free and SILAC quantitative proteome profiling strategies in primary retinal Müller cells , 2012, Proteomics.
[44] Steven A. Carr,et al. The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices , 2011, Molecular & Cellular Proteomics.
[45] W. Lawson,et al. Progress Toward Improving Animal Models for Idiopathic Pulmonary Fibrosis , 2011, The American journal of the medical sciences.
[46] Thomas R. Cox,et al. Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer , 2011, Disease Models & Mechanisms.
[47] L. Gleaves,et al. Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis. , 2010, American journal of physiology. Lung cellular and molecular physiology.
[48] Daniel N Cox,et al. Genomic phenotype of non-cultured pulmonary fibroblasts in idiopathic pulmonary fibrosis. , 2010, Genomics.
[49] Jong-Min Song,et al. Acute exacerbation of idiopathic pulmonary fibrosis: incidence, risk factors and outcome , 2010, European Respiratory Journal.
[50] A. Feuchtinger,et al. Deciphering Membrane-Associated Molecular Processes in Target Tissue of Autoimmune Uveitis by Label-Free Quantitative Mass Spectrometry* , 2010, Molecular & Cellular Proteomics.
[51] Spencer J. Williams,et al. Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates. , 2009, Bioorganic & medicinal chemistry letters.
[52] Markus Brosch,et al. Accurate and sensitive peptide identification with Mascot Percolator. , 2009, Journal of proteome research.
[53] M. Mann,et al. Universal sample preparation method for proteome analysis , 2009, Nature Methods.
[54] C. Speer,et al. The Role of Transforming Growth Factor β in Lung Development and Disease , 2004 .
[55] F. Verrecchia,et al. Transforming Growth Factor-β Signaling Through the Smad Pathway: Role in Extracellular Matrix Gene Expression and Regulation , 2002 .
[56] Xia Lin,et al. Smurf2 Is a Ubiquitin E3 Ligase Mediating Proteasome-dependent Degradation of Smad2 in Transforming Growth Factor-β Signaling* 210 , 2000, The Journal of Biological Chemistry.
[57] C. Heldin,et al. Specificity, diversity, and regulation in TGF‐β superfamily signaling , 1999 .
[58] R. Hammer,et al. Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice. , 1997, The Journal of clinical investigation.
[59] K. Csaky,et al. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. , 1997, The Journal of clinical investigation.
[60] E. Ruoslahti,et al. Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease , 1992, Nature.
[61] T. Sasaki,et al. Inhibition of prolyl hydroxylation during collagen biosynthesis in human skin fibroblast cultures by ethyl 3,4-dihydroxybenzoate. , 1987, The Journal of investigative dermatology.
[62] M. Isaji,et al. Selective inhibition of collagen accumulation by N-(3,4-dimethoxycinnamoyl)anthranilic acid (N-5') in granulation tissue. , 1987, Biochemical pharmacology.
[63] K. Flaherty,et al. A Phase 2 Randomized Controlled Study of Tralokinumab in Subjects with Idiopathic Pulmonary Fibrosis , 2018, American journal of respiratory and critical care medicine.
[64] H. Collard,et al. Efficacy of simtuzumab versus placebo in patients with idiopathic pulmonary fibrosis: a randomised, double-blind, controlled, phase 2 trial. , 2017, The Lancet. Respiratory medicine.
[65] A. B. Pour,et al. Tranilast: a review of its therapeutic applications. , 2015, Pharmacological research.
[66] Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis. , 2015, The New England journal of medicine.
[67] A. Azuma,et al. A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis , 2015 .
[68] B. Crestani,et al. Treatments for idiopathic pulmonary fibrosis. , 2014, The New England journal of medicine.
[69] C. Ronco,et al. Incidence, Risk Factors, and Outcome , 2014 .
[70] S. Rosselot. Idiopathic pulmonary fibrosis. , 2014, Nursing standard (Royal College of Nursing (Great Britain) : 1987).
[71] D. Lynch,et al. BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis. , 2011, American journal of respiratory and critical care medicine.
[72] 佐藤 三佐子. Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction , 2005 .