A case study of a multiply talented savant with an autism spectrum disorder: neuropsychological functioning and brain morphometry

Neuropsychological functioning and brain morphometry in a savant (case GW) with an autism spectrum disorder (ASD) and both calendar calculation and artistic skills are quantified and compared with small groups of neurotypical controls. Good memory, mental calculation and visuospatial processing, as well as (implicit) knowledge of calendar structure and ‘weak’ central coherence characterized the cognitive profile of case GW. Possibly reflecting his savant skills, the superior parietal region of GW's cortex was the only area thicker (while areas such as the superior and medial prefrontal, middle temporal and motor cortices were thinner) than that of a neurotypical control group. Taken from the perspective of learning/practice-based models, skills in domains (e.g. calendars, art, music) that capitalize upon strengths often associated with ASD, such as detail-focused processing, are probably further enhanced through over-learning and massive exposure, and reflected in atypical brain structure.

[1]  U. Frith,et al.  An islet of ability in autistic children: a research note. , 1983, Journal of child psychology and psychiatry, and allied disciplines.

[2]  B. Hermelin,et al.  Savants, segments, art and autism. , 1995, Journal of child psychology and psychiatry, and allied disciplines.

[3]  G. Wallace,et al.  Annotation: the savant syndrome. , 2004, Journal of child psychology and psychiatry, and allied disciplines.

[4]  F. Happé,et al.  What aspects of autism predispose to talent? , 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

[5]  Jean-Francois Mangin,et al.  Automatized clustering and functional geometry of human parietofrontal networks for language, space, and number , 2004, NeuroImage.

[6]  F. Happé,et al.  Brief Report: Information Processing Speed is Intact in Autism but not Correlated with Measured Intelligence , 2009, Journal of autism and developmental disorders.

[7]  M. Anderson,et al.  Annotation: conceptions of intelligence. , 2001, Journal of child psychology and psychiatry, and allied disciplines.

[8]  Donald K. Routh.  Bright Splinters of the Mind: A Personal Story of Research With Autistic Savants , 2002 .

[9]  Liang-sheng Lu,et al.  [Expression of fusion proteins in beta(2)GP I gene-transfected HEp-2 cells and its clinical application]. , 2002, Zhonghua yi xue za zhi.

[10]  Richard S. J. Frackowiak,et al.  Navigation-related structural change in the hippocampi of taxi drivers. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[11]  B. Hermelin,et al.  A date to remember: the nature of memory in savant calendrical calculators , 1999, Psychological Medicine.

[12]  S. Baron-Cohen,et al.  Talent in autism: hyper-systemizing, hyper-attention to detail and sensory hypersensitivity , 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

[13]  N. Hadjikhani,et al.  Anatomical differences in the mirror neuron system and social cognition network in autism. , 2006, Cerebral cortex.

[14]  N. O’connor,et al.  Idiot savant calendrical calculators: rules and regularities , 1986, Psychological Medicine.

[15]  B. Hermelin,et al.  A Specific Calculating Ability. , 1998 .

[16]  N. O’connor,et al.  The memory structure of autistic idiot-savant mnemonists. , 1989, British journal of psychology.

[17]  J. Kranzler,et al.  Meta-analysis of the relationship between intelligence and inspection time , 2001 .

[18]  Scott P. Johnson,et al.  Visual statistical learning in infancy: evidence for a domain general learning mechanism , 2002, Cognition.

[19]  Simon Baron-Cohen,et al.  Sally normal sex differences functioning autism , and − Asperger syndrome or high The systemizing quotient : an investigation of adults with , 2003 .

[20]  N. O’connor,et al.  Talents and preoccupations in idiots-savants , 1991, Psychological Medicine.

[21]  D G Gadian,et al.  Calculation difficulties in children of very low birthweight: a neural correlate. , 2001, Brain : a journal of neurology.

[22]  Y. Chen.  [The change of serum alpha 1-antitrypsin level in patients with spontaneous pneumothorax]. , 1995, Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.

[23]  S. Baron-Cohen,et al.  The Empathy Quotient: An Investigation of Adults with Asperger Syndrome or High Functioning Autism, and Normal Sex Differences , 2004, Journal of autism and developmental disorders.

[24]  D. Shanks.  IMPLICIT LEARNING AND TACIT KNOWLEDGE - AN ESSAY ON THE COGNITIVE UNCONSCIOUS - REBER,A , 1995 .

[25]  Stanislas Dehaene,et al.  Arithmetic and the Brain This Review Comes from a Themed Issue on Cognitive Neuroscience Edited the Intraparietal Sulcus and Number Sense Number Sense in the Animal Brain , 2022 .

[26]  D. C. Howell,et al.  Comparing an Individual's Test Score Against Norms Derived from Small Samples , 1998 .

[27]  Michiru Makuuchi,et al.  Both parietal lobes are involved in drawing: a functional MRI study and implications for constructional apraxia. , 2003, Brain research. Cognitive brain research.

[28]  S. Baron-Cohen,et al.  Are intuitive physics and intuitive psychology independent? A test with children with Asperger Syndrome. , 2001 .

[29]  C. Richards,et al.  Brain activity during visual versus kinesthetic imagery: An fMRI study , 2009, Human brain mapping.

[30]  S. Mostofsky,et al.  Evidence for a deficit in procedural learning in children and adolescents with autism: Implications for cerebellar contribution , 2000, Journal of the International Neuropsychological Society.

[31]  D. Treffert,et al.  Extraordinary People: Understanding "Idiot Savants" , 1989 .

[32]  Alan C. Evans,et al.  Cortical thickness analysis examined through power analysis and a population simulation , 2005, NeuroImage.

[33]  D. Louis Collins,et al.  Tuning and Comparing Spatial Normalization Methods , 2003, MICCAI.

[34]  U. Frith,et al.  High “intelligence,” low “IQ”? Speed of processing and measured IQ in children with autism , 2000, Development and Psychopathology.

[35]  Elizabeth K. Warrington,et al.  Arithmetic Skills in Patients with Unilateral Cerebral Lesions , 1986, Cortex.

[36]  L. Mottron,et al.  A Study of Perceptual Analysis in a High-Level Autistic Subject with Exceptional Graphic Abilities , 1993, Brain and Cognition.

[37]  Richard Cowan,et al.  The skills and methods of calendrical savants , 2003 .

[38]  C. Frith,et al.  The Neural Basis of Mentalizing , 2006, Neuron.

[39]  Bogdan Draganski,et al.  Neuroplasticity: Changes in grey matter induced by training , 2004, Nature.

[40]  Michael Anderson,et al.  Conceptions of Intelligence , 2001 .

[41]  U. Frith,et al.  The Weak Coherence Account: Detail-focused Cognitive Style in Autism Spectrum Disorders , 2006, Journal of autism and developmental disorders.

[42]  H. A. Witkin.  A Manual for the embedded figures tests , 1971 .

[43]  N O'Connor,et al.  Intelligence and musical improvisation , 1989, Psychological Medicine.

[44]  Richard Cowan,et al.  Do calendrical savants use calculation to answer date questions? A functional magnetic resonance imaging study , 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

[45]  William D Gaillard,et al.  Intact implicit learning of spatial context and temporal sequences in childhood autism spectrum disorder. , 2008, Neuropsychology.

[46]  F. Happé,et al.  Wechsler IQ profile and theory of mind in autism: a research note. , 1994, Journal of child psychology and psychiatry, and allied disciplines.