Diurnal Variation in the Response of the Mandible to Orthopedic Force

Bone and cartilage metabolism is known to be more active during rest than during periods of activity. The purpose of this study was to examine the hypothesis that mandibular retractive force could be more effective when applied to rats during rest. Mandibular retractive force caused a considerable reduction in the condylar length in experimental groups, and the magnitude of this reduction was greater in the Light-period (08:00-20:00) group than in the Dark-period (20:00-08:00) group. The differentiation and proliferation of chondrocytes were inhibited in animals in the Light-period group, compared with those in the Dark-period group. These results suggest that the orthopedic effects of mandibular retractive force vary depending on the time of day the force is applied, and that such force may be more effective while animals are resting than while they are active.

[1]  H. Mitani,et al.  Tooth movement and changes in periodontal tissue in response to orthodontic force in rats vary depending on the time of day the force is applied. , 2001, European journal of orthodontics.

[2]  H. Mitani,et al.  Compressive force promotes chondrogenic differentiation and hypertrophy in midpalatal suture cartilage in growing rats , 2000, The Anatomical record.

[3]  H. Mitani,et al.  Formation and mineralization of murine molar roots with hypocalcaemia induced by a low-calcium diet and the changes after returning to a normal diet. , 1999, Archives of oral biology.

[4]  B. Lemmer.  Chronopharmacokinetics: Implications for Drug Treatment , 1999, The Journal of pharmacy and pharmacology.

[5]  H. Shinoda,et al.  Circadian Rhythms in the Incorporation and Secretion of 3H-proline by Odontoblasts in Relation to Incremental Lines in Rat Dentin , 1998, Journal of dental research.

[6]  H. Mitani,et al.  Diurnal variation in tooth movement in response to orthodontic force in rats. , 1998, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

[7]  R. Parker,et al.  Diurnal Variation of Bone Mineral Turnover in Elderly Men and Women , 1997, Calcified Tissue International.

[8]  I. Ashkenazi,et al.  Diurnal rhythm of prostanoid secretion from bone/marrow organ in the rat. , 1995, Bone.

[9]  H. Mitani,et al.  Effects of lateral pterygoid muscle hyperactivity on differentiation of mandibular condyles in rats , 1995, The Anatomical record.

[10]  S. Saeki.  Diurnal rhythms in the collagen-synthetic activities of cartilage cells and osteoblasts in the rat mandibular condyle , 1995 .

[11]  Nielsen Hk.  Circadian and circatrigintan changes in osteoblastic activity assessed by serum osteocalcin. Physiological and methodological aspects. , 1994 .

[12]  H. Fleisch,et al.  A method for continual monitoring of bone resorption in rats: evidence for a diurnal rhythm. , 1990, The American journal of physiology.

[13]  C. P. Leblond,et al.  Cellular stages in cartilage formation as revealed by morphometry, radioautography and type II collagen immunostaining of the mandibular condyle from weanling rats. , 1988, The American journal of anatomy.

[14]  R. Leapman,et al.  Further characterisation of the extracellular matrix in the mandibular condyle in neonatal mice. , 1987, Journal of anatomy.

[15]  T. Asano.  The effects of mandibular retractive force on the growing rat mandible. , 1986, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

[16]  C. Kielty,et al.  Type X collagen, a product of hypertrophic chondrocytes. , 1985, The Biochemical journal.

[17]  Y. Takasaki,et al.  A nuclear antigen associated with cell proliferation and blast transformation , 1981, The Journal of experimental medicine.

[18]  T. Graber.  Turn-over of human alveolar bone removed either in the day or in the night , 1981 .

[19]  L. Rotkin,et al.  Circadian rhythms of blood minerals in humans. , 1981, Science.

[20]  A. Petrovic,et al.  Turn‐over of human alveolar bone removed either in the day or in the night , 1981 .

[21]  W. E. Roberts,et al.  Circadian periodicity of the cell kinetics of rat molar periodontal ligament. , 1979, American journal of orthodontics.

[22]  F. H. Tyler,et al.  Circadian rhythm in serum parathyroid hormone concentration in human subjects: correlation with serum calcium, phosphate, albumin, and growth hormone levels. , 1972, The Journal of clinical investigation.

[23]  D. Simmons,et al.  Diurnal periodicity in the metabolic activity of bone tissue. , 1966, The American journal of physiology.

[24]  D. Simmons.  Diurnal Periodicity in Epiphyseal Growth Cartilage , 1962, Nature.

[25]  H. Mitani,et al.  An immunohistochemical study of localization of type I and type II collagens in mandibular condylar cartilage compared with tibial growth plate , 2004, Histochemistry.

[26]  Phillip L. Gould,et al.  Time-Dependent Effects , 1994 .

[27]  M. Burritt,et al.  Circadian variation in ionized calcium and intact parathyroid hormone: evidence for sex differences in calcium homeostasis. , 1991, The Journal of clinical endocrinology and metabolism.

[28]  A. Petrovic,et al.  Time-dependent effects of a 'functional'-type orthopedic appliance on the rat mandible growth. , 1984, Chronobiology international.