Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300

[1]  Xiaoxiang Zheng,et al.  Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage , 2017, Cell Death & Disease.

[2]  P. Ramírez,et al.  Immunosuppressive potency of mechanistic target of rapamycin inhibitors in solid-organ transplantation. , 2016, World journal of transplantation.

[3]  F. Cecconi,et al.  Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice , 2015, Autophagy.

[4]  A. Chagin,et al.  Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis , 2015, Annals of the rheumatic diseases.

[5]  A. Carr,et al.  Osteoarthritis , 2015, The Lancet.

[6]  M. Lotz,et al.  The Relationship of Autophagy Defects to Cartilage Damage During Joint Aging in a Mouse Model , 2015, Arthritis & rheumatology.

[7]  M. Maiuri,et al.  Spermidine induces autophagy by inhibiting the acetyltransferase EP300 , 2014, Cell Death and Differentiation.

[8]  P. Klenerman,et al.  Autophagy is a critical regulator of memory CD8+ T cell formation , 2014, eLife.

[9]  Nektarios Tavernarakis,et al.  Spermidine protects against α-synuclein neurotoxicity , 2014, Cell cycle.

[10]  J. Pelletier,et al.  Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis , 2014, Annals of the rheumatic diseases.

[11]  Sang Gyun Kim,et al.  Rapamycin: one drug, many effects. , 2014, Cell metabolism.

[12]  J. Saklatvala,et al.  Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo. , 2012, Arthritis and rheumatism.

[13]  Qinxi Li,et al.  GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy , 2012, Science.

[14]  Oliver Distler,et al.  Basic and translational research , 2011 .

[15]  D. Rubinsztein,et al.  Autophagy and Aging , 2011, Cell.

[16]  F. Madeo,et al.  Polyamines in aging and disease , 2011, Aging.

[17]  M. Lotz,et al.  Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. , 2010, Arthritis and rheumatism.

[18]  Frank Sinner,et al.  Induction of autophagy by spermidine promotes longevity , 2009, Nature Cell Biology.

[19]  L. Marton,et al.  Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases , 2007, Nature Reviews Drug Discovery.

[20]  Martin Michaelis,et al.  Osteoarthritis — an untreatable disease? , 2005, Nature Reviews Drug Discovery.

[21]  L. Alhonen,et al.  Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue , 1999 .

[22]  N. Mizushima.  Methods for monitoring autophagy using GFP-LC3 transgenic mice. , 2009, Methods in enzymology.

[23]  T. Ueno,et al.  LC3 and Autophagy. , 2008, Methods in molecular biology.

[24]  L. Alhonen,et al.  Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue. , 1999, The Biochemical journal.