Recurrent eczema herpeticum – a retrospective European multicenter study evaluating the clinical characteristics of eczema herpeticum cases in atopic dermatitis patients

Eczema herpeticum (EH) is a disseminated viral infection of eczematous skin disease with the herpes simplex virus. Knowledge on clinical characteristics, risk factors and recurrent disease is limited. Our aim was to better define clinical characteristics and risk factors for EH and especially for recurrent EH.

[1]  A. Muraro,et al.  Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I , 2018, Journal of the European Academy of Dermatology and Venereology : JEADV.

[2]  D. Koelle,et al.  Patients with atopic dermatitis and history of eczema herpeticum elicit herpes simplex virus-specific type 2 immune responses. , 2017, The Journal of allergy and clinical immunology.

[3]  F. Khan,et al.  Management of eczema herpeticum in a Burn Unit. , 2016, JPMA. The Journal of the Pakistan Medical Association.

[4]  C. Akdis,et al.  Cellular and molecular immunologic mechanisms in patients with atopic dermatitis. , 2016, The Journal of allergy and clinical immunology.

[5]  A. Verceles,et al.  A Fatal Case of Eczema Herpeticum With Septic Shock Due to Methicillin-Resistant Staphylococcus aureus. , 2016, American journal of critical care : an official publication, American Association of Critical-Care Nurses.

[6]  Sung Won Kim,et al.  Relationship Between the Presence of Eczema Herpeticum and the Significance of Clinical and Laboratory Tests in Korean Children With Atopic Dermatitis , 2016, Iranian journal of pediatrics.

[7]  J. Ring,et al.  ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients , 2016, Journal of the European Academy of Dermatology and Venereology : JEADV.

[8]  T. Shiohara,et al.  Pathological Role of Regulatory T Cells in the Initiation and Maintenance of Eczema Herpeticum Lesions , 2014, The Journal of Immunology.

[9]  D. Leung.  Why is eczema herpeticum unexpectedly rare? , 2013, Antiviral research.

[10]  Samir S. Shah,et al.  Topical Corticosteroids and Hospital Length of Stay in Children with Eczema Herpeticum , 2013, Pediatric dermatology.

[11]  E. Pope,et al.  Eczema herpeticum in children: clinical features and factors predictive of hospitalization. , 2012, The Journal of pediatrics.

[12]  I. Dekio,et al.  Recurrent Kaposi’s varicelliform eruption successfully controlled by low‐dose oral valaciclovir , 2012, The Journal of dermatology.

[13]  Samir S. Shah,et al.  Delayed Acyclovir and Outcomes of Children Hospitalized With Eczema Herpeticum , 2011, Pediatrics.

[14]  K. Barnes,et al.  Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis. , 2011, The Journal of allergy and clinical immunology.

[15]  K. Barnes,et al.  Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response. , 2011, The Journal of allergy and clinical immunology.

[16]  K. Barnes,et al.  Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. , 2009, The Journal of allergy and clinical immunology.

[17]  T. Bieber,et al.  Risk factors of atopic dermatitis patients for eczema herpeticum. , 2007, The Journal of investigative dermatology.

[18]  M. Boguniewicz,et al.  Severe refractory atopic dermatitis in adults is highly atopic. , 2007, The Journal of allergy and clinical immunology.

[19]  M. Flaig,et al.  Cathelicidin deficiency predisposes to eczema herpeticum. , 2006, The Journal of allergy and clinical immunology.

[20]  S. Wetzel,et al.  Eczema herpeticatum , 2004, Der Hautarzt.

[21]  G. Plewig,et al.  Predisposing factors and clinical features of eczema herpeticum: a retrospective analysis of 100 cases. , 2003, Journal of the American Academy of Dermatology.

[22]  K. Umene,et al.  Close association of predominant genotype of herpes simplex virus type 1 with eczema herpeticum analyzed using restriction fragment length polymorphism of polymerase chain reaction. , 2003, Journal of virological methods.

[23]  G. Hartmann,et al.  Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases. , 2002, The Journal of investigative dermatology.

[24]  P. Spear,et al.  Disruption of Adherens Junctions Liberates Nectin-1 To Serve as Receptor for Herpes Simplex Virus and Pseudorabies Virus Entry , 2002, Journal of Virology.

[25]  C. Akdis,et al.  Epidemiology, clinical features, and immunology of the “intrinsic” (non‐IgE‐mediated) type of atopic dermatitis (constitutional dermatitis) , 2001, Allergy.

[26]  J. Ring,et al.  The excess of atopic eczema in East Germany is related to the intrinsic type , 2000, The British journal of dermatology.

[27]  C. Akdis,et al.  Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis. , 1999, Journal of immunology.

[28]  A. Taieb,et al.  Contact allergy to aeroallergens in children with atopic dermatitis: comparison with allergic contact dermatitis , 1996, Contact dermatitis.

[29]  K. Bork,et al.  Increasing incidence of eczema herpeticum: analysis of seventy-five cases. , 1988, Journal of the American Academy of Dermatology.

[30]  M. Savage,et al.  Eczema herpeticum: a potentially fatal disease. , 1987, British medical journal.

[31]  M. Longson,et al.  Herpes simplex infections in atopic eczema. , 1985, Archives of disease in childhood.

[32]  Andreas Wollenberg.  Eczema herpeticum. , 2012, Chemical immunology and allergy.

[33]  W. Aberer,et al.  Recurrent Herpes Simplex Infection in Multiple Locations in an Otherwise Healthy Boy , 2010, Pediatric dermatology.

[34]  M. Ambo,et al.  Relapsing Kaposi's varicelliform eruption and herpes simplex following facial tacrolimus treatment for atopic dermatitis. , 2002, Acta dermato-venereologica.

[35]  D. Baker,et al.  Treatment of Recurrent Eczema Herpeticum in Pregnancy With Acyclovir , 1996, Infectious diseases in obstetrics and gynecology.

[36]  Julia Brasch,et al.  Severity Scoring of Atopic Dermatitis: The SCORAD Index , 1993 .

[37]  G. Rajka,et al.  Grading of the severity of atopic dermatitis. , 1989, Acta dermato-venereologica. Supplementum.