Voltammetric Determination of Folic Acid with a Overoxidized Polypyrrole Film Modified Sol-Gel Carbon Ceramic Electrode

The electrochemical behavior of folic acid (FA)was studied at an overoxidized polypyrrole modified carbon ceramic electrode using cyclic voltammetry. The numerous factors affecting the oxidation peak currents of folic acid on the response of the electrode were optimized to maximize sensitivity. The modified electrode presented a linear response range for FA concentration from 7 to 55 µM, 0.1 to 25 µM, and from 0.49 to 7.8 µM with detection limits of 1.8 × 10−6, 3.1 × 10−8, and 2.7 × 10−7 for cyclic voltammetry, differential pulse voltammetry, and amperometric techniques, respectively. The results showed that the OPPy-modified electrode has very high catalytic ability for electrooxidation of FA. The modified electrode exhibited excellent sensitivity and stability. The application of the modified electrode was demonstrated for determination of folic acid in biological and other real samples.

[1]  M. Majidi,et al.  Simultaneous Determination of Ascorbic Acid and Uric Acid in Blood Serum Using an Overoxidized Polypyrrole Film Modified Glassy Carbon Electrode , 2010 .

[2]  H. Zamani,et al.  Simultaneous Voltammetric Determination of Norepinephrine and Folic Acid at the Surface of Modified Carbon Nanotube Paste Electrode , 2011, International Journal of Electrochemical Science.

[3]  Wen‐Chien Lee,et al.  Killing of cancer cell line by photoexcitation of folic acid-modified titanium dioxide nanoparticles , 2009 .

[4]  M. Marco,et al.  Immunoassay for folic acid detection in vitamin-fortified milk based on electrochemical magneto sensors. , 2009, Biosensors & bioelectronics.

[5]  K. Asadpour‐Zeynali,et al.  Amperometric Biosensor for Dopamine Determination Based on Over-Oxidized Polypyrrole-Plant Tissue Composite , 2009 .

[6]  Fei Xiao,et al.  Single-walled carbon nanotube-ionic liquid paste electrode for the sensitive voltammetric determination of folic acid , 2008 .

[7]  Yücel Şahin,et al.  Ion chromatography-potentiometric detection of inorganic anions and cations using polypyrrole and overoxidized polypyrrole electrode , 2008 .

[8]  Jin‐Ming Lin,et al.  Determination of folic acid by chemiluminescence based on peroxomonosulfate-cobalt(II) system. , 2008, Talanta.

[9]  Johan D M Patring,et al.  Application of liquid chromatography-electrospray ionisation mass spectrometry for determination of dietary folates: effects of buffer nature and mobile phase composition on sensitivity and selectivity. , 2007, Journal of chromatography. A.

[10]  Mandong Guo,et al.  Voltammetric behavior study of folic acid at phosphomolybdic-polypyrrole film modified electrode , 2006 .

[11]  K. Asadpour‐Zeynali,et al.  Voltammetric behavior and determination of isoniazid in pharmaceuticals by using overoxidized polypyrrole glassy carbon modified electrode , 2006 .

[12]  Dan Xiao,et al.  Determination of folic acid by capillary electrophoresis with chemiluminescence detection. , 2006, Journal of chromatography. A.

[13]  G. C. Peñalvo,et al.  Capillary electrophoretic determination of methotrexate, leucovorin and folic acid in human urine. , 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[14]  J. Arcot,et al.  Enzyme protein binding assay for determining folic acid in fortified cereal foods and stability of folic acid under different extraction conditions , 2002 .

[15]  Dietmar E. Breithaupt,et al.  Determination of folic acid by ion-pair RP-HPLC in vitamin-fortified fruit juices after solid-phase extraction , 2001 .

[16]  Indian,et al.  FOLIC ACID REVISITED , 2001 .

[17]  P. Christensen,et al.  IN SITU SPECTROSCOPIC INVESTIGATIONS OF THE GROWTH, ELECTROCHEMICAL CYCLING AND OVEROXIDATION OF POLYPYRROLE IN AQUEOUS SOLUTION , 1991 .

[18]  N. Oyama,et al.  Permselectivity of films prepared by electrochemical oxidation of phenol and amino-aromatic compounds , 1983 .