A feedback SIR (fSIR) model highlights advantages and limitations of infection-based social distancing

Transmission rates in epidemic outbreaks vary over time depending on the societal and government response to infections and mortality data, as evidenced in the course of the COVID-19 pandemic. Following a mean field approach that models individuals like molecules in a well-mixed solution, I derive a modified SIR model in which the average daily contacts between susceptible and infected population are reduced based on the known infection levels, capturing the effects of social distancing policies. This approach yields a time-varying reproduction number that is continuously adjusted based on infection information through a negative-feedback term that is equivalent to Holling type II functions in ecology and Hill functions in chemistry and molecular biology. This feedback-adjustment of the transmission rate causes a structural reduction in infection peak, and simulations indicate that such reduction persists even in the presence of information delays. Simulations also show that a distancing policy based on infection data may substantially extend the duration of an epidemic. If the distancing rate is linearly proportional to infections, this model adds a single parameter to the original SIR, making it useful to illustrate the effects of social distancing enforced based on awareness of infections.

[1]  W. O. Kermack,et al.  A contribution to the mathematical theory of epidemics , 1927 .

[2]  HighWire Press Proceedings of the Royal Society of London. Series A, Containing papers of a mathematical and physical character , 1934 .

[3]  H. Hethcote Qualitative analyses of communicable disease models , 1976 .

[4]  G. Serio,et al.  A generalization of the Kermack-McKendrick deterministic epidemic model☆ , 1978 .

[5]  S. Levin,et al.  Dynamical behavior of epidemiological models with nonlinear incidence rates , 1987, Journal of mathematical biology.

[6]  Philip K Maini,et al.  Non-linear incidence and stability of infectious disease models. , 2005, Mathematical medicine and biology : a journal of the IMA.

[7]  Neil M. Ferguson,et al.  The effect of public health measures on the 1918 influenza pandemic in U.S. cities , 2007, Proceedings of the National Academy of Sciences.

[8]  Deborah Lacitignola,et al.  Global stability of an SIR epidemic model with information dependent vaccination. , 2008, Mathematical biosciences.

[9]  C. Watkins,et al.  The spread of awareness and its impact on epidemic outbreaks , 2009, Proceedings of the National Academy of Sciences.

[10]  Yasuhiro Takeuchi,et al.  Global Stability for Delay SIR and SEIR Epidemic Models with Nonlinear Incidence Rate , 2010, Bulletin of mathematical biology.

[11]  I. Kiss,et al.  The impact of information transmission on epidemic outbreaks. , 2010, Mathematical biosciences.

[12]  P. Olver Nonlinear Systems , 2013 .

[13]  Sudip Samanta,et al.  Effect of awareness program in disease outbreak - A slow-fast dynamics , 2014, Appl. Math. Comput..

[14]  M. K. Mak,et al.  Exact analytical solutions of the Susceptible-Infected-Recovered (SIR) epidemic model and of the SIR model with equal death and birth rates , 2014, Appl. Math. Comput..

[15]  Sudip Samanta,et al.  Awareness programs control infectious disease - Multiple delay induced mathematical model , 2015, Appl. Math. Comput..

[16]  Daihai He,et al.  Effects of reactive social distancing on the 1918 influenza pandemic , 2017, PloS one.

[17]  R. Baker,et al.  Reactive Social distancing in a SIR model of epidemics such as COVID-19 , 2020, 2003.08285.

[18]  Elisa Franco,et al.  The challenges of modeling and forecasting the spread of COVID-19 , 2020, Proceedings of the National Academy of Sciences.

[19]  M. Lipsitch,et al.  Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period , 2020, Science.

[20]  Francesco Casella Can the COVID-19 epidemic be managed on the basis of daily data? , 2020, ArXiv.

[21]  Yang Liu,et al.  Early dynamics of transmission and control of COVID-19: a mathematical modelling study , 2020, The Lancet Infectious Diseases.

[22]  E. Crisostomi,et al.  On Fast Multi-Shot COVID-19 Interventions for Post Lock-Down Mitigation , 2020 .

[23]  P. Colaneri,et al.  Modelling the COVID-19 epidemic and implementation of population-wide interventions in Italy , 2020, Nature Medicine.

[24]  Piet Van Mieghem,et al.  Network-based prediction of the 2019-nCoV epidemic outbreak in the Chinese province Hubei , 2020 .

[25]  J. Xiang,et al.  Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study , 2020, The Lancet.

[26]  P. Klepac,et al.  Early dynamics of transmission and control of COVID-19: a mathematical modelling study , 2020, The Lancet Infectious Diseases.

[27]  E. Dong,et al.  An interactive web-based dashboard to track COVID-19 in real time , 2020, The Lancet Infectious Diseases.

[28]  T. Parisini,et al.  On Fast Multi-Shot Epidemic Interventions for Post Lock-Down Mitigation: Implications for Simple Covid-19 Models , 2020, ArXiv.

[29]  Francesco Casella,et al.  Can the COVID-19 Epidemic Be Controlled on the Basis of Daily Test Reports? , 2020, IEEE Control Systems Letters.