High-Field-Strength Magnetic Resonance: Potential and Limits

Objective: To expatiate on the possible advantages and disadvantages of high magnetic field strengths for magnetic resonance imaging and, in particular, for magnetic resonance angiography. Methods and Results: A review of the available literature is given, presenting many of the advantages and disadvantages of imaging at higher field strengths. Focus is put on imaging at 3 to 7 T. Early results at 7 T are presented; these results indicate that several of the angiographic techniques commonly used at lower field strengths show promise for improvement by taking advantage of the higher signal and susceptibility sensitivity at 7 T. Conclusions: The drive toward higher field strengths, both for the purpose of fundamental research and for clinical diagnostic imaging, is likely to continue. New applications using the unique properties of high field strength will almost certainly emerge as researchers gain more experience. The ultimate limiting factor is likely to be the physiological effects at high field strengths. However, this limit seems to lie at field strengths higher than 7 T because early experience shows good tolerance of 7 T examinations.

[1]  Yu-Chung N. Cheng,et al.  Susceptibility weighted imaging (SWI) , 2004, Zeitschrift fur medizinische Physik.

[2]  J. Schenck,et al.  High‐field magnetic resonance imaging of brain iron: birth of a biomarker? , 2004, NMR in biomedicine.

[3]  W. Heindel,et al.  Effect of Field Strengths on Magnetic Resonance Angiography: Comparison of an Ultrasmall Superparamagnetic Iron Oxide Blood-Pool Contrast Agent and Gadopentetate Dimeglumine in Rabbits at 1.5 and 3.0 Tesla , 2006, Investigative radiology.

[4]  C. Kuhl,et al.  Brain tumors: full- and half-dose contrast-enhanced MR imaging at 3.0 T compared with 1.5 T--Initial Experience. , 2005, Radiology.

[5]  P. Röschmann,et al.  Susceptibility artefacts in NMR imaging. , 1985, Magnetic resonance imaging.

[6]  Zahi A Fayad,et al.  Plaque imaging and characterization using magnetic resonance imaging: towards molecular assessment. , 2006, Current molecular medicine.

[7]  J. DeMarco,et al.  3.0 T versus 1.5 T MR angiography of the head and neck. , 2006, Neuroimaging clinics of North America.

[8]  Douglas C Noll,et al.  Fast‐kz three‐dimensional tailored radiofrequency pulse for reduced B1 inhomogeneity , 2006, Magnetic resonance in medicine.

[9]  J. Finn,et al.  High-spatial-resolution whole-body MR angiography with high-acceleration parallel acquisition and 32-channel 3.0-T unit: initial experience. , 2007, Radiology.

[10]  P Mansfield,et al.  Real-time echo-planar imaging by NMR. , 1984, British medical bulletin.

[11]  Susan M. Chang,et al.  Feasibility of dynamic susceptibility contrast perfusion MR imaging at 3T using a standard quadrature head coil and eight‐channel phased‐array coil with and without SENSE reconstruction , 2006, Journal of magnetic resonance imaging : JMRI.

[12]  Risto A. Kauppinen,et al.  Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging , 1998, Nature Medicine.

[13]  Keith Heberlein,et al.  Inherent insensitivity to RF inhomogeneity in FLASH imaging , 2004, Magnetic resonance in medicine.

[14]  I. Nöbauer-Huhmann,et al.  The optimal use of contrast agents at high field MRI , 2006, European Radiology.

[15]  V. Fuchs,et al.  Physicians' views of the relative importance of thirty medical innovations. , 2001, Health affairs.

[16]  O. Simonetti,et al.  Coronary artery wall imaging: Initial experience at 3 Tesla , 2005, Journal of magnetic resonance imaging : JMRI.

[17]  E. Atalar,et al.  Ultimate intrinsic signal‐to‐noise ratio in MRI , 1998, Magnetic resonance in medicine.

[18]  M. Schnall,et al.  Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla , 2002, Magnetic resonance in medicine.

[19]  J. R. Long,et al.  Ultra-wide bore 900 MHz high-resolution NMR at the National High Magnetic Field Laboratory. , 2005, Journal of magnetic resonance.

[20]  Thoralf Niendorf,et al.  Toward single breath‐hold whole‐heart coverage coronary MRA using highly accelerated parallel imaging with a 32‐channel MR system , 2006, Magnetic resonance in medicine.

[21]  H. Schild [Clinical highfield MR]. , 2005, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[22]  Michael B. Smith,et al.  Central brightening due to constructive interference with, without, and despite dielectric resonance , 2005, Journal of magnetic resonance imaging : JMRI.

[23]  D C Harrison,et al.  Dynamic gadolinium‐enhanced three‐dimensional abdominal MR arteriography , 1993, Journal of magnetic resonance imaging : JMRI.

[24]  Peter Börnert,et al.  Free‐breathing whole‐heart coronary MR angiography on a clinical scanner in four minutes , 2006, Journal of magnetic resonance imaging : JMRI.

[25]  Xiaoping Hu,et al.  Advances in high-field magnetic resonance imaging. , 2004, Annual review of biomedical engineering.

[26]  J. Detre,et al.  Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla , 2005, Journal of magnetic resonance imaging : JMRI.

[27]  Jian-Ming Jin,et al.  Computation of the signal-to-noise ratio of high-frequency magnetic resonance imagers , 2000, IEEE Transactions on Biomedical Engineering.

[28]  K. Uğurbil,et al.  Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo , 2007, Magnetic resonance in medicine.

[29]  H C Charles,et al.  Reproducibility of relaxation and spin‐density parameters in phantoms and the human brain measured by MR imaging at 1.5T , 1986, Magnetic resonance in medicine.

[30]  Peter Boesiger,et al.  Optimizing spatiotemporal sampling for k‐t BLAST and k‐t SENSE: Application to high‐resolution real‐time cardiac steady‐state free precession , 2005, Magnetic resonance in medicine.

[31]  E. Moser,et al.  Proton NMR relaxation times of human blood samples at 1.5 T and implications for functional MRI. , 1997, Cellular and molecular biology.

[32]  C. Kuhl,et al.  High-field-strength MR imaging of the liver at 3.0 T: intraindividual comparative study with MR imaging at 1.5 T. , 2006, Radiology.

[33]  P. Kellman,et al.  Improved cine displacement‐encoded MRI using balanced steady‐state free precession and time‐adaptive sensitivity encoding parallel imaging at 3 T , 2007, NMR in biomedicine.

[34]  P. Börnert,et al.  Basic considerations on the impact of the coil array on the performance of Transmit SENSE , 2005, Magnetic Resonance Materials in Physics, Biology and Medicine.

[35]  Kamil Ugurbil,et al.  Potential and feasibility of parallel MRI at high field , 2006, NMR in biomedicine.

[36]  S. Holland,et al.  NMR relaxation times in the human brain at 3.0 tesla , 1999, Journal of magnetic resonance imaging : JMRI.

[37]  René M. Botnar,et al.  Initial experiences with in vivo right coronary artery human MR vessel wall imaging at 3 tesla. , 2003, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[38]  V B Ho,et al.  Chemical shift: the artifact and clinical tool revisited. , 1999, Radiographics : a review publication of the Radiological Society of North America, Inc.

[39]  L. Kramer,et al.  Dynamic contrast‐enhanced MRI study of male pelvic perfusion at 3T: Preliminary clinical report , 2007, Journal of magnetic resonance imaging : JMRI.

[40]  Siegfried Trattnig,et al.  Effect of Contrast Dose and Field Strength in the Magnetic Resonance Detection of Brain Metastases , 2003, Investigative radiology.

[41]  J Paul Finn,et al.  Cardiac Cine Imaging at 3 Tesla: Initial Experience With a 32-Element Body-Array Coil , 2006, Investigative radiology.

[42]  P. Boesiger,et al.  SENSE: Sensitivity encoding for fast MRI , 1999, Magnetic resonance in medicine.

[43]  Donald W Chakeres,et al.  Limits of 8‐Tesla magnetic resonance imaging spatial resolution of the deoxygenated cerebral microvasculature , 2004, Journal of magnetic resonance imaging : JMRI.

[44]  Matt A Bernstein,et al.  Imaging artifacts at 3.0T , 2006, Journal of magnetic resonance imaging : JMRI.

[45]  John F Schenck,et al.  Physical interactions of static magnetic fields with living tissues. , 2005, Progress in biophysics and molecular biology.

[46]  A. Wright,et al.  High-resolution black-blood MRI of the carotid vessel wall using phased-array coils at 1.5 and 3 Tesla. , 2005, Academic radiology.

[47]  Wei Chen,et al.  Study of Brain Function and Bioenergetics using fMRI and In Vivo MRS at High Fields , 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

[48]  A. Kangarlu,et al.  Human magnetic resonance imaging at 8 T , 1998, NMR in biomedicine.

[49]  V. Haughton,et al.  T1 and T2 measurements on a 1.5-T commercial MR imager. , 1989, Radiology.

[50]  G. Adam,et al.  MRI of the coronary vessel wall at 3 T: comparison of radial and cartesian k-space sampling. , 2007, AJR. American journal of roentgenology.

[51]  E. Larsson,et al.  Comparison of contrast agents with high molarity and with weak protein binding in cerebral perfusion imaging at 3 T , 2005, Journal of magnetic resonance imaging : JMRI.

[52]  Martin R Prince,et al.  3D contrast‐enhanced MR angiography , 2007, Journal of magnetic resonance imaging : JMRI.

[53]  Michael B. Smith,et al.  Exploring the limits of RF shimming for high‐field MRI of the human head , 2006, Magnetic resonance in medicine.

[54]  Hart,et al.  Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla. , 1984, Radiology.

[55]  M. Weigel,et al.  Inversion recovery prepared turbo spin echo sequences with reduced SAR using smooth transitions between pseudo steady states , 2007, Magnetic resonance in medicine.

[56]  K. Uğurbil,et al.  Parallel imaging performance as a function of field strength—An experimental investigation using electrodynamic scaling , 2004, Magnetic resonance in medicine.

[57]  Hans-Joachim Mentzel,et al.  Susceptibility weighted imaging: data acquisition, image reconstruction and clinical applications. , 2006, Zeitschrift fur medizinische Physik.

[58]  A. Kangarlu,et al.  Randomized comparison of cognitive function in humans at 0 and 8 Tesla , 2003, Journal of magnetic resonance imaging : JMRI.

[59]  H. Schild,et al.  Klinische Hochfeld-MRT , 2005 .

[60]  Jürgen Hennig,et al.  Experimental analysis of parallel excitation using dedicated coil setups and simultaneous RF transmission on multiple channels , 2005, Magnetic resonance in medicine.

[61]  C L Dumoulin,et al.  Human exposure to 4.0-Tesla magnetic fields in a whole-body scanner. , 1992, Medical physics.

[62]  Risto A. Kauppinen,et al.  Determination of Oxygen Extraction Ratios by Magnetic Resonance Imaging , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[63]  T. Ibrahim,et al.  Proposed radiofrequency phased‐array excitation scheme for homogenous and localized 7‐Tesla whole‐body imaging based on full‐wave numerical simulations , 2007, Magnetic resonance in medicine.

[64]  F Ståhlberg,et al.  Effects of echo time variation on perfusion assessment using dynamic susceptibility contrast MR imaging at 3 tesla. , 2004, Magnetic resonance imaging.

[65]  Peter Börnert,et al.  Parallel RF transmission in MRI , 2006, NMR in biomedicine.

[66]  A. Kangarlu,et al.  High resolution MRI of the deep brain vascular anatomy at 8 Tesla: susceptibility-based enhancement of the venous structures. , 1999, Journal of computer assisted tomography.

[67]  Peter Börnert,et al.  Theoretical and numerical aspects of transmit SENSE , 2004, IEEE Transactions on Medical Imaging.

[68]  X Golay,et al.  Non-invasive Measurement of Perfusion: a Critical Review of Arterial Spin Labelling Techniques , 2022 .

[69]  L. Brateman Chemical shift imaging: a review. , 1986, AJR. American journal of roentgenology.

[70]  P A Rinck,et al.  Nuclear relaxation of human brain gray and white matter: Analysis of field dependence and implications for MRI , 1990, Magnetic resonance in medicine.

[71]  R S Balaban,et al.  MR relaxation times in human brain: measurement at 4 T. , 1996, Radiology.

[72]  P. Lauterbur,et al.  The sensitivity of the zeugmatographic experiment involving human samples , 1979 .

[73]  Klaas P Pruessmann,et al.  Parallel Imaging at High Field Strength: Synergies and Joint Potential , 2004, Topics in magnetic resonance imaging : TMRI.

[74]  G. Adam,et al.  Coronary vessel-wall and lumen imaging using radial k-space acquisition with MRI at 3 Tesla , 2007, European Radiology.

[75]  J. Debatin,et al.  Rapid magnetic resonance angiography for detection of atherosclerosis , 2001, The Lancet.

[76]  A. Wilman,et al.  Vessel contrast at three Tesla in time-of-flight magnetic resonance angiography of the intracranial and carotid arteries. , 2002, Magnetic resonance imaging.

[77]  D. Berman,et al.  Rapid assessment of left ventricular segmental wall motion, ejection fraction, and volumes with single breath-hold, multi-slice TrueFISP MR imaging. , 2006, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[78]  Juergen Hennig,et al.  Contrast behavior and relaxation effects of conventional and hyperecho‐turbo spin echo sequences at 1.5 and 3 T , 2006, Magnetic resonance in medicine.

[79]  Douglas C Noll,et al.  Small tip angle three‐dimensional tailored radiofrequency slab‐select pulse for reduced B1 inhomogeneity at 3 T , 2005, Magnetic resonance in medicine.

[80]  R. Goebel,et al.  7T vs. 4T: RF power, homogeneity, and signal‐to‐noise comparison in head images , 2001, Magnetic resonance in medicine.

[81]  J. Schenck,et al.  Health and Physiological Effects of Human Exposure to Whole‐Body Four‐Tesla Magnetic Fields during MRI , 1992, Annals of the New York Academy of Sciences.

[82]  O. Simonetti,et al.  Multislice dark‐blood carotid artery wall imaging: A 1.5 T and 3.0 T comparison , 2006, Journal of magnetic resonance imaging : JMRI.

[83]  Kawin Setsompop,et al.  Parallel RF transmission with eight channels at 3 Tesla , 2006, Magnetic resonance in medicine.

[84]  J. Meaney Magnetic resonance angiography of the peripheral arteries: current status , 2003, European Radiology.

[85]  D. Hoult Sensitivity and Power Deposition in a High‐Field Imaging Experiment , 2000, Journal of magnetic resonance imaging : JMRI.

[86]  A. Mühler,et al.  Early distribution dynamics of polymeric magnetic resonance imaging contrast agents in rats. , 2002, Academic radiology.

[87]  H. Weinmann,et al.  First use of GdDTPA/dimeglumine in man. , 1984, Physiological chemistry and physics and medical NMR.

[88]  J. Glockner,et al.  3 Tesla MR imaging provides improved contrast in first-pass myocardial perfusion imaging over a range of gadolinium doses. , 2005, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[89]  Carissa G. Fonseca,et al.  Pulmonary MR perfusion at 3.0 Tesla using a blood pool contrast agent: Initial results in a swine model , 2007, Journal of magnetic resonance imaging : JMRI.

[90]  P. Boesiger,et al.  Electrodynamics and ultimate SNR in parallel MR imaging , 2004, Magnetic resonance in medicine.

[91]  Susan M. Chang,et al.  Dynamic susceptibility-weighted perfusion imaging of high-grade gliomas: characterization of spatial heterogeneity. , 2005, AJNR. American journal of neuroradiology.

[92]  W. Martin,et al.  MR Spectroscopy in Neurodegenerative Disease , 2007, Molecular Imaging and Biology.

[93]  Reeti Tandon,et al.  High-field Magnetic Resonance Imaging of Brain Iron in Alzheimer Disease , 2006, Topics in magnetic resonance imaging : TMRI.

[94]  Xavier Golay,et al.  Arterial spin labeling: benefits and pitfalls of high magnetic field. , 2006, Neuroimaging clinics of North America.

[95]  Alayar Kangarlu,et al.  Effect of static magnetic field exposure of up to 8 Tesla on sequential human vital sign measurements , 2003, Journal of magnetic resonance imaging : JMRI.

[96]  C Gabriel,et al.  The dielectric properties of biological tissues: I. Literature survey. , 1996, Physics in medicine and biology.

[97]  Horst Urbach,et al.  Time-of-flight MR angiography: comparison of 3.0-T imaging and 1.5-T imaging--initial experience. , 2003, Radiology.

[98]  A. Kangarlu,et al.  High resolution MRI of the deep gray nuclei at 8 Tesla. , 1999, Journal of computer assisted tomography.

[99]  Christopher J. Hardy,et al.  Spatial localization in two dimensions using NMR designer pulses , 1989 .

[100]  C. Kramer,et al.  MRI of atherosclerosis: diagnosis and monitoring therapy , 2007, Expert review of cardiovascular therapy.

[101]  J. Finn,et al.  Renal Magnetic Resonance Angiography at 3.0 Tesla Using a 32-Element Phased-Array Coil System and Parallel Imaging in 2 Directions , 2006, Investigative radiology.

[102]  Jeff H. Duyn,et al.  Extensive heterogeneity in white matter intensity in high-resolution T2 *-weighted MRI of the human brain at 7.0 T , 2006, NeuroImage.

[103]  P. Börnert,et al.  Transmit SENSE , 2003, Magnetic resonance in medicine.

[104]  J. Pauly,et al.  Simultaneous spatial and spectral selective excitation , 1990, Magnetic resonance in medicine.

[105]  J R Reichenbach,et al.  High-Resolution MR Venography at 3.0 Tesla , 2000, Journal of computer assisted tomography.

[106]  G. Glover,et al.  Neuroimaging at 1.5 T and 3.0 T: Comparison of oxygenation‐sensitive magnetic resonance imaging , 2001, Magnetic resonance in medicine.

[107]  B. Mueller,et al.  Signal‐to‐noise ratio and spectral linewidth improvements between 1.5 and 7 Tesla in proton echo‐planar spectroscopic imaging , 2006, Magnetic resonance in medicine.

[108]  J. Schenck,et al.  NMR IMAGING/SPECTROSCOPY SYSTEM TO STUDY BOTH ANATOMY AND METABOLISM , 1983, The Lancet.

[109]  David G Norris,et al.  High field human imaging , 2003, Journal of magnetic resonance imaging : JMRI.

[110]  Yudong Zhu,et al.  Parallel excitation with an array of transmit coils , 2004, Magnetic resonance in medicine.

[111]  A. Shmuel,et al.  Imaging brain function in humans at 7 Tesla , 2001, Magnetic resonance in medicine.

[112]  Hans H Schild,et al.  Three-dimensional dynamic susceptibility-weighted perfusion MR imaging at 3.0 T: feasibility and contrast agent dose. , 2005, Radiology.

[113]  Steen Moeller,et al.  B1 destructive interferences and spatial phase patterns at 7 T with a head transceiver array coil , 2005, Magnetic resonance in medicine.

[114]  G C McKinnon,et al.  Breath-hold, contrast-enhanced, three-dimensional MR angiography. , 1996, Radiology.

[115]  Peter Andersen,et al.  Proton T2 relaxation study of water, N‐acetylaspartate, and creatine in human brain using Hahn and Carr‐Purcell spin echoes at 4T and 7T , 2002, Magnetic resonance in medicine.

[116]  K. Uğurbil,et al.  Manipulation of image intensity distribution at 7.0 T: Passive RF shimming and focusing with dielectric materials , 2006, Journal of magnetic resonance imaging : JMRI.

[117]  John Huston,et al.  Reduction of RF power for magnetization transfer with optimized application of RF pulses in k‐space , 2003, Magnetic resonance in medicine.