The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes
暂无分享,去创建一个
Joshua A. Bittker | P. Clemons | S. Schreiber | V. Dancík | B. Wagner | F. Wagner | Amit Choudhary | Allison Hands | Allison T Hands
[1] I. Pavlinov,et al. Multiple Chemical Features Impact Biological Performance Diversity of a Highly Active Natural Product‐Inspired Library , 2020, Chembiochem : a European journal of chemical biology.
[2] Stuart L Schreiber,et al. Recent achievements and current trajectories of diversity-oriented synthesis. , 2020, Current opinion in chemical biology.
[3] Olivier Sperandio,et al. Fr-PPIChem: An academic compound library dedicated to protein-protein interactions. , 2020, ACS chemical biology.
[4] Yuan Wang,et al. Systematic Chemogenetic Library Assembly , 2020, bioRxiv.
[5] David R. Liu,et al. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9 , 2019, Cell.
[6] David R. Liu,et al. Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme , 2019, Nature Chemical Biology.
[7] Hans Briem,et al. An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer - against all odds? , 2019, Drug discovery today.
[8] Stephen J. Wright,et al. Predicting kinase inhibitors using bioactivity matrix derived informer sets , 2019, bioRxiv.
[9] Andrew I. Su,et al. The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis , 2018, Proceedings of the National Academy of Sciences.
[10] Douglas B Kell,et al. Analysing and Navigating Natural Products Space for Generating Small, Diverse, But Representative Chemical Libraries , 2018, Biotechnology journal.
[11] Jacob K. Asiedu,et al. The Drug Repurposing Hub: a next-generation drug library and information resource , 2017, Nature Medicine.
[12] Lyn H. Jones,et al. Applications of chemogenomic library screening in drug discovery , 2017, Nature Reviews Drug Discovery.
[13] Andreas Bender,et al. Data-Driven Derivation of an "Informer Compound Set" for Improved Selection of Active Compounds in High-Throughput Screening , 2016, J. Chem. Inf. Model..
[14] Bruce K. Hua,et al. Real-Time Biological Annotation of Synthetic Compounds , 2016, Journal of the American Chemical Society.
[15] Manuel Llinás,et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond , 2016, PLoS pathogens.
[16] Anne E Carpenter,et al. Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes , 2016, Nature Protocols.
[17] Shelby K Doyle,et al. Advances in discovering small molecules to probe protein function in a systems context. , 2015, Current opinion in chemical biology.
[18] Joshua A. Bittker,et al. Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset. , 2015, Cancer discovery.
[19] M. Disney,et al. Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy. , 2015, ACS chemical biology.
[20] Andrew L Hopkins,et al. The Joint European Compound Library: boosting precompetitive research. , 2015, Drug discovery today.
[21] Dragos Horvath,et al. Design of a General‐Purpose European Compound Screening Library for EU‐OPENSCREEN , 2014, ChemMedChem.
[22] Philippe Roche,et al. Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space. , 2014, Future medicinal chemistry.
[23] Anne E Carpenter,et al. Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling , 2014, Proceedings of the National Academy of Sciences.
[24] Anne Mai Wassermann,et al. Composition and applications of focus libraries to phenotypic assays , 2014, Front. Pharmacol..
[25] David R. Liu,et al. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones , 2014, Nature.
[26] Nicole E. Bodycombe,et al. Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses , 2014, Journal of biomolecular screening.
[27] Anne E Carpenter,et al. Multiplex Cytological Profiling Assay to Measure Diverse Cellular States , 2013, PloS one.
[28] P. Jeffrey Conn,et al. Bringing together the academic drug discovery community , 2013, Nature Reviews Drug Discovery.
[29] Joshua C. Gilbert,et al. An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules , 2013, Cell.
[30] P. Nordlund,et al. Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay , 2013, Science.
[31] Noel Southall,et al. Selecting, Acquiring, and Using Small Molecule Libraries for High‐Throughput Screening , 2012, Current protocols in chemical biology.
[32] Giovanni Muncipinto,et al. Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries. , 2012, The Journal of organic chemistry.
[33] Peter S. Kutchukian,et al. Rethinking molecular similarity: comparing compounds on the basis of biological activity. , 2012, ACS chemical biology.
[34] Ruth Brenk,et al. Mining the ChEMBL Database: An Efficient Chemoinformatics Workflow for Assembling an Ion Channel-Focused Screening Library , 2011, J. Chem. Inf. Model..
[35] Patrick W. Faloon,et al. Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis. , 2011, ACS medicinal chemistry letters.
[36] Dana Pe'er,et al. Modulatory profiling identifies mechanisms of small molecule-induced cell death , 2011, Proceedings of the National Academy of Sciences.
[37] Sivaraman Dandapani,et al. Current strategies for diversity-oriented synthesis. , 2010, Current opinion in chemical biology.
[38] Hugo O Villar,et al. Design of chemical libraries for screening , 2009, Expert opinion on drug discovery.
[39] Jörg Rademann,et al. Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept , 2009, Molecular Diversity.
[40] Anang A Shelat,et al. Scaffold composition and biological relevance of screening libraries. , 2007, Nature chemical biology.
[41] David R Spring,et al. Enriching chemical space with diversity-oriented synthesis. , 2006, Current opinion in drug discovery & development.
[42] A. Fliri,et al. Biological spectra analysis: Linking biological activity profiles to molecular structure. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[43] S. Schreiber,et al. Target-oriented and diversity-oriented organic synthesis in drug discovery. , 2000, Science.
[44] Nicholas A. Clark,et al. Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries. , 2019, Cell chemical biology.
[45] E. Sharlow. Benefits of Strategic Small-Scale Targeted Screening. , 2016, Assay and drug development technologies.