Enabling Technologies for the Future of Chemical Synthesis

Technology is evolving at breakneck pace, changing the way we communicate, travel, find out information, and live our lives. Yet chemistry as a science has been slower to adapt to this rapidly shifting world. In this Outlook we use highlights from recent literature reports to describe how progresses in enabling technologies are altering this trend, permitting chemists to incorporate new advances into their work at all levels of the chemistry development cycle. We discuss the benefits and challenges that have arisen, impacts on academic–industry relationships, and future trends in the area of chemical synthesis.

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[37]  Claudio Battilocchio,et al.  A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds** , 2015, Angewandte Chemie.

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[46]  Jun-ichi Yoshida,et al.  Flash Chemistry: Fast Organic Synthesis in Microsystems , 2008 .

[47]  Marie-Françoise Reyniers,et al.  Computational Study and Kinetic Analysis of the Aminolysis of Thiolactones. , 2015, The Journal of organic chemistry.

[48]  Kevin Bateman,et al.  Nanomole-scale high-throughput chemistry for the synthesis of complex molecules , 2015, Science.

[49]  Volker Hessel,et al.  Novel process windows for enabling, accelerating, and uplifting flow chemistry. , 2013, ChemSusChem.

[50]  Steven V Ley,et al.  Flow chemistry syntheses of natural products. , 2013, Chemical Society reviews.

[51]  Claudio Battilocchio,et al.  Process Intensification for the Continuous Flow Hydrogenation of Ethyl Nicotinate , 2014 .

[52]  Claudio Battilocchio,et al.  Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439. , 2015, Organic letters.

[53]  George M Whitesides,et al.  Reinventing chemistry. , 2015, Angewandte Chemie.

[54]  Julien Rossignol,et al.  Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography , 2014 .

[55]  Philip J. Kitson,et al.  Integrated 3D-printed reactionware for chemical synthesis and analysis. , 2012, Nature chemistry.

[56]  Richard J Ingham,et al.  Organic synthesis: march of the machines. , 2015, Angewandte Chemie.

[57]  Magnus Rueping,et al.  Self‐Optimizing Reactor Systems: Algorithms, On‐Line Analytics, Setups, and Strategies for Accelerating Continuous Flow Process Optimization , 2014 .

[58]  Steven V Ley,et al.  Continuous flow chemistry: a discovery tool for new chemical reactivity patterns. , 2014, Organic & biomolecular chemistry.

[59]  Magnus Rueping,et al.  Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems , 2016 .

[60]  Claudio Battilocchio,et al.  Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide. , 2014, Organic Letters.

[61]  Claudio Battilocchio,et al.  Machine‐Assisted Organic Synthesis , 2015, Angewandte Chemie.

[62]  Duncan Guthrie,et al.  Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen , 2013 .