Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression.

Phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK) is a key enzyme in the synthesis of glucose in the liver and kidney and of glyceride-glycerol in white adipose tissue and the small intestine. The gene for the cytosolic form of PEPCK (PEPCK-C) is acutely regulated by a variety of dietary and hormonal signals, which result in alteration of synthesis of the enzyme. Major factors that increase PEPCK-C gene expression include cyclic AMP, glucocorticoids, and thyroid hormone, whereas insulin inhibits this process. PEPCK-C is absent in fetal liver but appears at birth, concomitant with the capacity for gluconeogenesis. Regulatory elements that control transcription of the PEPCK-C gene in liver, kidney, and adipose tissue have been delineated, and many of the transcription factors that bind to these elements have been identified. Transgenic mice have been especially useful in elucidating the physiological roles of specific sequence elements in the PEPCK-C gene promoter and in demonstrating the key role played at these sites by the isoforms of CAAT/enhancer binding protein in patterning of PEPCK-C gene expression during the perinatal period. The PEPCK-C gene provides a model for the metabolic control of gene transcription.

[1]  M. Olive,et al.  CCAAT-enhancer-binding protein α (C/EBPα) is required for the thyroid hormone but not the retinoic acid induction of phosphoenolpyruvate carboxykinase (PEPCK) gene transcription , 1997 .

[2]  A. Gurney,et al.  The promoter regulatory regions of the genes for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) from the chicken and the rat have different species-specific roles in gluconeogenesis. , 1997, The Journal of nutrition.

[3]  G. Darlington,et al.  Animal models for studying the genetic basis of metabolic regulation. , 1996, The Journal of nutrition.

[4]  C. Vinson,et al.  The -Isoform of the CCAAT/Enhancer-binding Protein Is Required for Mediating cAMP Responsiveness of the Phosphoenolpyruvate Carboxykinase Promoter in Hepatoma Cells (*) , 1996, The Journal of Biological Chemistry.

[5]  K. Kaestner,et al.  Severe impairment of permatogenesis in mice lacking the CREM gene , 1996, Nature.

[6]  A. Dierich,et al.  Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice , 1996, Nature.

[7]  M. Yaniv,et al.  Hepatocyte Nuclear Factor 1 Inactivation Results in Hepatic Dysfunction, Phenylketonuria, and Renal Fanconi Syndrome , 1996, Cell.

[8]  L. Delbaere,et al.  Crystal structure of Escherichia coli phosphoenolpyruvate carboxykinase: a new structural family with the P-loop nucleoside triphosphate hydrolase fold. , 1996, Journal of molecular biology.

[9]  J. Flier,et al.  Insulin Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression Does Not Require Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway (*) , 1996, The Journal of Biological Chemistry.

[10]  R. Printz,et al.  Structural and functional analysis of the human phosphoenolpyruvate carboxykinase gene promoter. , 1995, Biochimica et biophysica acta.

[11]  M. Leppert,et al.  Linkage Analysis of 19 Candidate Regions for Insulin Resistance in Familial NIDDM , 1995, Diabetes.

[12]  G. Darlington,et al.  C/EBPα: a critical regulator of genes governing integrative metabolic processes , 1995 .

[13]  A. Bradley,et al.  Impaired energy homeostasis in C/EBP alpha knockout mice , 1995, Science.

[14]  G. Sen,et al.  The Cyclic AMP Response Elements of the Genes for Angiotensin-converting Enzyme and Phosphoenolpyruvate Carboxykinase (GTP) Can Mediate Transcriptional Activation by CREMτ and CREMα (*) , 1995, The Journal of Biological Chemistry.

[15]  A. Aguzzi,et al.  Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. , 1995, Genes & development.

[16]  R. O’Brien,et al.  Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin , 1995, The Journal of Biological Chemistry.

[17]  R. Cortese,et al.  Lymphoproliferative disorder and imbalanced T‐helper response in C/EBP beta‐deficient mice. , 1995, The EMBO journal.

[18]  J. Wang,et al.  Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes , 1995, Molecular and cellular biology.

[19]  Nobuaki Yoshida,et al.  Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages , 1995, Cell.

[20]  F. Sladek,et al.  The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[21]  O. MacDougald,et al.  Insulin Regulates Transcription of the CCAAT/Enhancer Binding Protein (C/EBP) , , and Genes in Fully-differentiated 3T3-L1 Adipocytes (*) , 1995, The Journal of Biological Chemistry.

[22]  B. Spiegelman,et al.  PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene , 1995, Molecular and cellular biology.

[23]  R. O’Brien,et al.  Potential convergence of insulin and cAMP signal transduction systems at the phosphoenolpyruvate carboxykinase (PEPCK) gene promoter through CCAAT/enhancer binding protein (C/EBP). , 1994, The Journal of biological chemistry.

[24]  M. Gossen,et al.  Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[25]  D. Granner,et al.  Expression of the phosphoenolpyruvate carboxykinase gene in 3T3-F442A adipose cells: effects of retinoic acid and differentiation. , 1994, The Biochemical journal.

[26]  F. Bosch,et al.  Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[27]  Y Wang,et al.  A regulatory system for use in gene transfer. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[28]  S. Thorgeirsson,et al.  Expression of hepatic transcription factors during liver development and oval cell differentiation , 1994, The Journal of cell biology.

[29]  Wolfgang Schmid,et al.  Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[30]  A. Diehl,et al.  Selective induction of CCAAT/enhancer binding protein isoforms occurs during rat liver development. , 1994, Gastroenterology.

[31]  B. Spiegelman,et al.  mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. , 1994, Genes & development.

[32]  J. Beckmann,et al.  Search for a Third Susceptibility Gene for Maturity-Onset Diabetes of the Young: Studies With Eleven Candidate Genes , 1994, Diabetes.

[33]  J. Liu,et al.  An analysis of regulatory elements in the phosphoenolpyruvate carboxykinase (GTP) gene which are responsible for its tissue-specific expression and metabolic control in transgenic mice. , 1994, The Journal of biological chemistry.

[34]  Y. Patel,et al.  Phosphoenolpyruvate carboxykinase (GTP): the gene and the enzyme. , 1994, Advances in enzymology and related areas of molecular biology.

[35]  Y. Hod,et al.  A cAMP-regulated RNA-binding protein that interacts with phosphoenolpyruvate carboxykinase (GTP) mRNA. , 1993, The Journal of biological chemistry.

[36]  J. D. Engel Developmental regulation of human beta-globin gene transcription: a switch of loyalties? , 1993, Trends in genetics : TIG.

[37]  J. Friedman,et al.  Glucocorticoids regulate the induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes. , 1993, The Journal of biological chemistry.

[38]  C. Glass,et al.  Interaction between the thyroid hormone receptor and co-factors on the promoter of the gene encoding phospho enol pyruvate carboxykinase. , 1993, Biochimica et biophysica acta.

[39]  W. Roesler,et al.  Evidence for the involvement of at least two distinct transcription factors, one of which is liver-enriched, for the activation of the phosphoenolpyruvate carboxykinase gene promoter by cAMP. , 1993, The Journal of biological chemistry.

[40]  Stuart H. Orkin,et al.  Regulation of the β-globin locus , 1993 .

[41]  M. Stoffel,et al.  cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young. , 1993, Human molecular genetics.

[42]  P. Emson,et al.  Regional localization of the gene coding for human brain nitric oxide synthase (NOS1) to 12q24.2-->24.31 by fluorescent in situ hybridization. , 1993, Cytogenetics and cell genetics.

[43]  E. Noisin,et al.  Activation of the phosphoenolpyruvate carboxykinase gene retinoic acid response element is dependent on a retinoic acid receptor/coregulator complex , 1992, Molecular and cellular biology.

[44]  S. Cereghini,et al.  Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles. , 1992, Development.

[45]  K. Jungermann,et al.  Modulation of the glucagon‐dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures Evidence for a heme protein as oxygen sensor , 1992, FEBS letters.

[46]  W. Roesler,et al.  The liver-enriched transcription factor D-site-binding protein activates the promoter of the phosphoenolpyruvate carboxykinase gene in hepatoma cells. , 1992, The Journal of biological chemistry.

[47]  J. Liu,et al.  Opposing actions of Fos and Jun on transcription of the phosphoenolpyruvate carboxykinase (GTP) gene. Dominant negative regulation by Fos. , 1992, The Journal of biological chemistry.

[48]  Tony Ip,et al.  Characterization of the factors binding to a PEPCK gene upstream hypersensitive site with LCR activity , 1992, Nucleic Acids Res..

[49]  H. Cohen,et al.  Differential regulation of the rat phosphoenolpyruvate carboxykinase gene expression in several tissues of transgenic mice , 1992, Molecular and cellular biology.

[50]  R. O’Brien,et al.  Molecular Physiology and Genetics of NIDDM: Importance of Metabolic Staging , 1992, Diabetes Care.

[51]  R. Hammer,et al.  Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice , 1992, Molecular and cellular biology.

[52]  T. Geary,et al.  Cloning of a cDNA encoding phosphoenolpyruvate carboxykinase from Haemonchus contortus. , 1992, Molecular and biochemical parasitology.

[53]  C. Geourjon,et al.  Sequence of the phosphoenolpyruvate carboxykinase-encoding cDNA from the rumen anaerobic fungus Neocallimastix frontalis: comparison of the amino acid sequence with animals and yeast. , 1992, Gene.

[54]  J. Liu,et al.  Identification of a thyroid hormone response element in the phosphoenolpyruvate carboxykinase (GTP) gene. Evidence for synergistic interaction between thyroid hormone and cAMP cis-regulatory elements. , 1991, The Journal of biological chemistry.

[55]  J. Liu,et al.  Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements. , 1991, The Journal of biological chemistry.

[56]  K. Jungermann,et al.  Modulation by oxygen of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures. , 1991, European journal of biochemistry.

[57]  N. Benvenisty,et al.  Cis-regulatory elements that confer differential expression upon the rat gene encoding phosphoenolpyruvate carboxykinase in kidney and liver. , 1991, Gene.

[58]  N. Curthoys,et al.  Effect of pH and bicarbonate on phosphoenolpyruvate carboxykinase and glutaminase mRNA levels in cultured renal epithelial cells. , 1991, The Journal of biological chemistry.

[59]  J. Hwang,et al.  Effect of acute alterations in acid-base balance on rat renal glutaminase and phosphoenolpyruvate carboxykinase gene expression. , 1991, The Journal of biological chemistry.

[60]  N J Cox,et al.  Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[61]  A. Schoolwerth Regulation of renal ammoniagenesis in metabolic acidosis. , 1991, Kidney international.

[62]  J. Liu,et al.  The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP) , 1990, Molecular and cellular biology.

[63]  K. Yamamoto,et al.  Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. , 1990, Science.

[64]  J. Gustafsson,et al.  Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene , 1990, Molecular and cellular biology.

[65]  R. O’Brien,et al.  Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence. , 1990, Molecular endocrinology.

[66]  R. O’Brien,et al.  Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. , 1990, Science.

[67]  R. Chalkley,et al.  Extinction of phosphoenolpyruvate carboxykinase gene expression is associated with loss of a specific chromatin-binding protein from a far upstream domain , 1990, Molecular and cellular biology.

[68]  D. Granner,et al.  Cyclic AMP-dependent protein kinase regulates transcription of the phosphoenolpyruvate carboxykinase gene but not binding of nuclear factors to the cyclic AMP regulatory element , 1990, Molecular and cellular biology.

[69]  N. Benvenisty,et al.  Developmentally regulated interactions of liver nuclear factors with the rat phosphoenolpyruvate carboxykinase promoter , 1990, Molecular and cellular biology.

[70]  M. Magnuson,et al.  Immunohistochemical localization of phosphoenolpyruvate carboxykinase in adult and developing mouse tissues. , 1990, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[71]  David H. Jones,et al.  The Activity of Phosphoenolpyruvate Carboxykinase throughout the Lactation Cycle of the Guinea Pig Mammary Gland , 1989, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[72]  W. Roesler,et al.  Identification of multiple protein binding domains in the promoter-regulatory region of the phosphoenolpyruvate carboxykinase (GTP) gene. , 1989, Journal of Biological Chemistry.

[73]  R. Chalkley,et al.  Hormonal regulation of phosphoenolpyruvate carboxykinase gene expression is mediated through modulation of an already disrupted chromatin structure , 1989, Molecular and cellular biology.

[74]  N. Benvenisty,et al.  Separate cis-regulatory elements confer expression of phosphoenolpyruvate carboxykinase (GTP) gene in different cell lines. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[75]  W. Roesler,et al.  Cyclic AMP and the induction of eukaryotic gene transcription. , 1988, The Journal of biological chemistry.

[76]  Y. Hod,et al.  Cyclic AMP stabilizes the mRNA for phosphoenolpyruvate carboxykinase (GTP) against degradation. , 1988, The Journal of biological chemistry.

[77]  E. Gundelfinger,et al.  Nucleotide and deduced amino acid sequence of the phosphoenolpyruvate carboxykinase (GTP) from Drosophila melanogaster. , 1987, Nucleic acids research.

[78]  N. Benvenisty,et al.  Glucocorticoids control phosphoenolpyruvate carboxykinase gene expression in a tissue specific manner. , 1987, Nucleic acids research.

[79]  N. Benvenisty,et al.  Developmental acquisition of DNase I sensitivity of the phosphoenolpyruvate carboxykinase (GTP) gene in rat liver. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[80]  A. Wynshaw-Boris,et al.  Differential Expression of the Genes for the Mitochondrial and Cytosolic Forms of Phosphoenolpyruvate Carboxykinase a , 1986, Annals of the New York Academy of Sciences.

[81]  Y. Hod,et al.  Nucleotide sequence of the mRNA encoding the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) from the chicken. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[82]  A. Wynshaw-Boris,et al.  Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains. , 1986, The Journal of biological chemistry.

[83]  A. Wynshaw-Boris,et al.  Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. I. Multiple hormone regulatory elements and the effects of enhancers. , 1986, The Journal of biological chemistry.

[84]  N. Benvenisty,et al.  Tissue-specific hypomethylation and expression of rat phosphoenolpyruvate carboxykinase gene induced by in vivo treatment of fetuses and neonates with 5-azacytidine. , 1985, Biochemistry.

[85]  K. Biemann,et al.  Rat hepatic cytosolic phosphoenolpyruvate carboxykinase (GTP). Structures of the protein, messenger RNA, and gene. , 1985, The Journal of biological chemistry.

[86]  R. Hanson,et al.  Thyroid hormone regulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat liver. , 1985, Biochemistry.

[87]  M. Hatzoglou,et al.  Processing of phosphoenolpyruvate carboxykinase (GTP) RNA in vivo. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[88]  R. Hanson,et al.  Effect of hormones on transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat kidney. , 1985, Biochemistry.

[89]  N. Benvenisty,et al.  Sequential changes in DNA methylation patterns of the rat phosphoenolpyruvate carboxykinase gene during development. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[90]  D. Granner,et al.  Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin. , 1984, The Journal of biological chemistry.

[91]  Y. Hod,et al.  The gene encoding the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) from the chicken. , 1984, The Journal of biological chemistry.

[92]  N. Benvenisty,et al.  Primary activation of cytosolic phosphoenolpyruvate carboxykinase gene in fetal rat liver and the biogenesis of its mRNA. , 1984, European journal of biochemistry.

[93]  D. Granner,et al.  Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin , 1983, Nature.

[94]  A. Wynshaw-Boris,et al.  Isolation and characterization of the gene coding for cytosolic phosphoenolpyruvate carboxykinase (GTP) from the rat. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[95]  W. Lamers,et al.  cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[96]  R. Hanson,et al.  Regulation of phosphoenolpyruvate carboxykinase (GTP) mRNA turnover in rat liver. , 1980, The Journal of biological chemistry.

[97]  D. Shouval,et al.  Premature appearance of hepatic phosphoenolpyruvate carboxykinase in fetal rats, not mediated by adenosine 3':5'-monophosphate. , 1979, European journal of biochemistry.

[98]  K. Gabbay,et al.  The infant of the diabetic mother: correlation of increased cord C-peptide levels with macrosomia and hypoglycemia. , 1979, The New England journal of medicine.

[99]  R. Rognstad Rate-limiting steps in metabolic pathways. , 1979, The Journal of biological chemistry.

[100]  L. Reshef,et al.  Effect of triamcinolone on renal and hepatic phosphoenolpyruvate carboxykinase in the newborn rat. Changes in the rate of synthesis of the enzyme and in the activity of its translatable messenger RNA. , 1979, European Journal of Biochemistry.

[101]  K. Jungermann,et al.  Heterogeneity of liver parenchymal cells , 1978 .

[102]  D. Kioussis,et al.  Alterations in translatable messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP) in rat liver cytosol during deinduction. , 1978, The Journal of biological chemistry.

[103]  R. Hanson,et al.  Messenger RNA for renal phosphoenolpyruvate carboxykinase (GTP). Its translation in a heterologous cell-free system and its regulation by glucocorticoids and by changes in acid-base balance. , 1977, The Journal of biological chemistry.

[104]  J. Vidnes,et al.  Glucagon Deficiency Causing Severe Neonatal Hypoglycemia in a Patient with Normal Insulin Secretion , 1977, Pediatric Research.

[105]  R. Hanson,et al.  Increase in level of functional messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP) during induction by cyclic adenosine 3':5'-monophosphate. , 1977, The Journal of biological chemistry.

[106]  J. Vidnes,et al.  GLUCONEOGENESIS IN INFANCY AND CHILDHOOD III. Deficiency of the Extramitochondrial Form of Hepatic Phosphoenolpyruvate Carboxykinase in a Case of Persistent Neonatal Hypoglycaemia , 1976, Acta paediatrica Scandinavica.

[107]  O. Meyuhas,et al.  Glucocorticoids and the regulation of phosphoenolpyruvate carboxykinase (guanosine triphosphate) in the rat. , 1975, The Biochemical journal.

[108]  R. Hanson,et al.  The regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat kidney cortex. The role of acid-base balance and glucocorticoids. , 1975, The Journal of biological chemistry.

[109]  S. Tilghman,et al.  Effects of cyclic adenosine monophosphate, dexamethasone and insulin on phosphoenolpyruvate carboxykinase synthesis in Reuber H-35 hepatoma cells. , 1975, Biochemistry.

[110]  S. Tilghman,et al.  Deinduction of phosphoenolpyruvate carboxykinase (guanosine triphosphate) synthesis in Reuber H-35 cells. , 1975, The Journal of biological chemistry.

[111]  J. Girard,et al.  Factors Affecting the Secretion of Insulin and Glucagon by the Rat Fetus , 1974, Diabetes.

[112]  S. Tilghman,et al.  Rapid loss of translatable messenger RNA of phosphoenolpyruvate carboxykinase during glucose repression in liver. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[113]  E. Marliss,et al.  Fuels, hormones, and liver metabolism at term and during the early postnatal period in the rat. , 1973, The Journal of clinical investigation.

[114]  F. Ballard,et al.  Synthesis and degradation of phosphoenolpyruvate carboxylase in rat liver and adipose tissue. Changes during a starvation-re-feeding cycle. , 1973, The Biochemical journal.

[115]  D. Kipnis,et al.  Hypoglycemia in infancy and childhood. Part II , 1973 .

[116]  R. Hanson,et al.  The regulation of phosphoenolpyruvate carboxykinase in fetal rat liver. , 1973, Enzyme.

[117]  P. Datta Homoserine dehydrogenase of Rhodospirillum rubrum. II. Purification and characterization of the enzyme. , 1970, The Journal of biological chemistry.

[118]  J. Anderson,et al.  Pyruvate carboxylase and phosphoenolpyruvate carboxykinase in rat intestinal mucosa. , 1970, Biochimica et biophysica acta.

[119]  G. Alleyne,et al.  Renal metabolic response to acid base changes. I. Enzymatic control of ammoniagenesis in the rat. , 1969, The Journal of clinical investigation.

[120]  I. Turkenkopf,et al.  Gluconeogenesis in developing rat kidney cortex. , 1969, The Biochemical journal.

[121]  D. Yeung,et al.  Induction of phosphopyruvate carboxylase in neonatal rat liver by adenosine 3',5'-cyclic monophosphate. , 1968, Biochemistry.

[122]  D. Yeung,et al.  Factors affecting the premature induction of phosphopyruvate carboxylase in neonatal rat liver. , 1968, The Biochemical journal.

[123]  R. Hanson,et al.  Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver. , 1967, The Biochemical journal.

[124]  G. Leveille,et al.  Phosphoenolpyruvate carboxykinase and the synthesis of glyceride-glycerol from pyruvate in adipose tissue. , 1967, The Journal of biological chemistry.

[125]  G. Cahill,et al.  Renal gluconeogenesis in acidosis, alkalosis, and potassium deficiency: its possible role in regulation of renal ammonia production. , 1966, The Journal of clinical investigation.

[126]  D. A. Bennett,et al.  Renal gluconeogenesis. The effect of diet on the gluconeogenic capacity of rat-kidney-cortex slices. , 1963, The Biochemical journal.

[127]  B. Houssay ADVANCEMENT OF KNOWLEDGE OF THE RôLE OF THE HYPOPHYSIS IN CARBOHYDRATE METABOLISM DURING THE LAST TWENTY-FIVE YEARS , 1942 .

[128]  C. Long,et al.  THE EFFECTS OF ADRENALECTOMY AND HYPOPHYSECTOMY UPON EXPERIMENTAL DIABETES IN THE CAT , 1936, The Journal of experimental medicine.